Protein Overview: PRPF3

General Information:
Name(s) found:	PRPF3 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|55666361\|emb\|CAH70312.1\| PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|4758556\|ref\|NP_004689.1\| PRP3 pre-mRNA processing factor 3 homolog [Homo sapiens] [NCBI NR] gi\|37082334\|sp\|O43395.2\|PRPF3_HUMAN RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3; AltName: Full=Pre-mRNA-splicing factor 3; Short=hPrp3; AltName: Full=U4/U6 snRNP 90 kDa protein [NCBI NR] gi\|2708307\|gb\|AAC51926.1\| U4/U6 small nuclear ribonucleoprotein hPrp3 [Homo sapiens] [NCBI NR] gi\|12805001\|gb\|AAH01954.1\| PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|12652863\|gb\|AAH00184.1\| PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|119573941\|gb\|EAW53556.1\| PRP3 pre-mRNA processing factor 3 homolog (yeast) [Homo sapiens] [NCBI NR] pir\|\|T50839 U4/U6 small nuclear ribonucleoprotein hPrp3 [imported] - human [NCBI NR] PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) [HGNC (HUGO)] U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens GN=PRPF3 PE=1 SV=2 [Swiss-Prot] (O43395) U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3) [Swiss-Prot] U4/U6 small nuclear ribonucleoprotein HPRP3 [hmr_yeast5_DM3-1_pombe.fasta] PRP3 pre-mRNA processing factor 3 homolog; U4/U6-associated RNA splicing factor; retinitis pigmentosa 18 (autosomal dominant) [HMR_022704.fasta] PRP3 pre-mRNA processing factor 3 homolog [Homo sapiens]gi\|55666361\|emb\|CAH70312.1\| PRP3 pre-mRNA processing factor 3 homolog (yeast) [Homo sapiens]gi\|12652863\|gb\|AAH00184.1\| PRP3 pre-mRNA processing factor 3 homolog [Homo sapiens]gi\|12805001\|gb\|AAH019 [nrdb_11152004_Chlamydomonas] U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_004698) U4/U6-associated RNA splicing factor [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] PRP3 pre-mRNA processing factor 3 homolog [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] PRP3 pre-mRNA processing factor 3 homolog; U4/U6-associated RNA splicing factor; retinitis pigmentosa 18 (autosomal dominant) [Homo sapiens] [HumanGallus06162005.fasta] U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] PRP3 pre-mRNA processing factor 3 homolog (yeast) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] U4/U6 small nuclear ribonucleoprotein hPrp3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 SPLICE ISOFORM 1 OF U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3; AltName: Full=Pre-mRNA-splicing factor 3; Short=hPrp3; AltName: Full=U4/U6 snRNP 90 kDa protein [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=PRPF3 Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 [human-ipi-250309-contam.fasta] U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3) [nr-271106-contam.fasta] IPI:IPI00005861.1\|SWISS-PROT:O43395-1\|TREMBL:B2R791;B4DLS8;B4DSY9;Q53GV6\|ENSEMBL:ENSP00000315379\|REFSEQ:NP_004689\|H-INV:HIT000062391\|VEGA:OTTHUMP00000014935 Tax_Id=9606 Gene_Symbol=PRPF3 Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=PRPF3 Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 ENSG00000117360 IPI00005861 IPI00377152 [drosphohumanreversed.fasta] O43395;O43446;Q5VT54; RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3; AltName: Full=Pre-mRNA-splicing factor 3; AltName: Full=U4/U6 snRNP 90 kDa protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens GN=PRPF3 [011711_HMR.fasta] GeneSymbol=PRPF3 Synonyms=HPRP3\|HPRP3P\|PRP3\|Prp3p\|RP18 U4/U6 small nuclear ribonucleoprotein Prp3 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00005861.1\|SWISS-PROT:O43395\|TREMBL:B2R791;B4DLS8;Q53GV6\|ENSEMBL:ENSP00000315379\|REFSEQ:NP_004689\|H-INV:HIT000062391\|VEGA:OTTHUMP00000014935 Tax_Id=9606 Gene_Symbol=PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 [ipi.HUMAN.20110912.fasta] U4/U6 small nuclear ribonucleoprotein Prp3 GN=PRPF3 [Doctor+uniprot-HUMAN-120911.fasta] Tax_Id=9606 Gene_Symbol=PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 [human-ipi-270911-contam-BSA.fasta]
Organism:	Homo sapiens
Length:	683 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH LKPFLDDSTL  60
   61 RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE ISKESSGVKK RRIPRFEEVE 120
  121 EEPEVIPGPP SESPGMLTKL QIKQMMEAAT RQIEERKKQL SFISPPTPQP KTPSSSQPER 180
  181 LPIGNTIQPS QAATFMNDAI EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI 240
  241 APPKVELKDQ TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK 300
  301 PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK LQAEISQAAR 360
  361 KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD LTEENPKRED YFGITNLVEH 420
  421 PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR QTRREAQKEL QEKVRLGLMP PPEPKVRISN 480
  481 LMRVLGTEAV QDPTKVEAHV RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG 540
  541 VHISVYRVRN LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 600
  601 RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ CPTENMAREH 660
  661 FKKHGAEHYW DLALSESVLE STD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..87]	PSI-BLAST	32.30103	Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)
2	View Details	[88..188]	deduced	N/A	No confident structure predictions are available.
3	View Details	[189..371]	MSA	1.040987	View MSA. No confident structure predictions are available.
4	View Details	[372..427]	MSA	1.044995	View MSA. No confident structure predictions are available.
5	View Details	[428..496]	MSA	1.045992	View MSA. No confident structure predictions are available.
6	View Details	[497..683]	FFAS03	1.1	No description for 2iygA was found.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: PRPF3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: