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Protein Overview: PLCB3

General Information:
Name(s) found: PLCB3 [HGNC (HUGO)]
Description(s) found:
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  • gi|836665|gb|AAA77683.1| phospholipase C-beta-3 [NCBI NR]
  • pir||I38994 phospholipase C-beta-3 - human [NCBI NR]
  • gi|1730573|sp|Q01970.2|PLCB3_HUMAN RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; AltName: Full=Phosphoinositide phospholipase C; AltName: Full=Phospholipase C-beta-3; Short=PLC-beta-3 [NCBI NR]
  • gi|148745659|gb|AAI42682.1| Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [NCBI NR]
  • gi|119594636|gb|EAW74230.1| phospholipase C, beta 3 (phosphatidylinositol-specific), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|11386139|ref|NP_000923.1| phospholipase C beta 3 [Homo sapiens] [NCBI NR]
  • phospholipase C, beta 3 (phosphatidylinositol-specific) [HGNC (HUGO)]
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens GN=PLCB3 PE=1 SV=2 [Swiss-Prot]
  • (Q01970) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-beta-3) (Phospholipase C-beta-3) [Swiss-Prot]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 [hmr_yeast5_DM3-1_pombe.fasta]
  • phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens]gi|1730573|sp|Q01970|PIB3_HUMAN 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (Phosphoinositide phospholipase C) (PLC-beta-3) (Phospholipase C-beta-3)gi|7435175|pir [nrdb_11152004_Chlamydomonas]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (Phosphoinositide phospholipase C) (PLC-beta-3) (Phospholipase C-beta-3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000932) phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • phospholipase C, beta 3 (phosphatidylinositol-specific), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • phospholipase C-beta-3 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA 3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PLCB3 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 [human-ipi-250309-contam.fasta]
  • phospholipase C beta 3 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (Phosphoinositide phospholipase C) (Phospholipase C-beta-3) (PLC-beta-3) [nr-271106-contam.fasta]
  • IPI:IPI00010400.1|SWISS-PROT:Q01970|TREMBL:A5PKZ6|ENSEMBL:ENSP00000279230|REFSEQ:NP_000923|H-INV:HIT000326766 Tax_Id=9606 Gene_Symbol=PLCB3 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PLCB3 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 ENSG00000149782 IPI00010400 IPI00181283 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PLCB3 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens GN=PLCB3 PE=1 SV=2 [UniProtHuman070710.fasta]
  • Q01970;A5PKZ6; RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; AltName: Full=Phosphoinositide phospholipase C-beta-3; AltName: Full=Phospholipase C-beta-3; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens GN=PLCB3 [011711_HMR.fasta]
  • IPI:IPI00010400.1|SWISS-PROT:Q01970|ENSEMBL:ENSP00000279230|REFSEQ:NP_000923|H-INV:HIT000326766 Tax_Id=9606 Gene_Symbol=PLCB3 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PLCB3 Synonyms=FLJ37084 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00010400.1|SWISS-PROT:Q01970|ENSEMBL:ENSP00000279230;ENSP00000443631|REFSEQ:NP_000923|H-INV:HIT000326766|VEGA:OTTHUMP00000236934;OTTHUMP00000236935 Tax_Id=9606 Gene_Symbol=PLCB3 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 [ipi.HUMAN.20110912.fasta]
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 GN=PLCB3 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 1234 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGAQPGVHA LQLEPPTVVE TLRRGSKFIK WDEETSSRNL VTLRVDPNGF FLYWTGPNME  60
   61 VDTLDISSIR DTRTGRYARL PKDPKIREVL GFGGPDARLE EKLMTVVSGP DPVNTVFLNF 120
  121 MAVQDDTAKV WSEELFKLAM NILAQNASRN TFLRKAYTKL KLQVNQDGRI PVKNILKMFS 180
  181 ADKKRVETAL ESCGLKFNRS ESIRPDEFSL EIFERFLNKL CLRPDIDKIL LEIGAKGKPY 240
  241 LTLEQLMDFI NQKQRDPRLN EVLYPPLRPS QARLLIEKYE PNQQFLERDQ MSMEGFSRYL 300
  301 GGEENGILPL EALDLSTDMT QPLSAYFINS SHNTYLTAGQ LAGTSSVEMY RQALLWGCRC 360
  361 VELDVWKGRP PEEEPFITHG FTMTTEVPLR DVLEAIAETA FKTSPYPVIL SFENHVDSAK 420
  421 QQAKMAEYCR SIFGDALLIE PLDKYPLAPG VPLPSPQDLM GRILVKNKKR HRPSAGGPDS 480
  481 AGRKRPLEQS NSALSESSAA TEPSSPQLGS PSSDSCPGLS NGEEVGLEKP SLEPQKSLGD 540
  541 EGLNRGPYVL GPADREDEEE DEEEEEQTDP KKPTTDEGTA SSEVNATEEM STLVNYIEPV 600
  601 KFKSFEAARK RNKCFEMSSF VETKAMEQLT KSPMEFVEYN KQQLSRIYPK GTRVDSSNYM 660
  661 PQLFWNVGCQ LVALNFQTLD VAMQLNAGVF EYNGRSGYLL KPEFMRRPDK SFDPFTEVIV 720
  721 DGIVANALRV KVISGQFLSD RKVGIYVEVD MFGLPVDTRR KYRTRTSQGN SFNPVWDEEP 780
  781 FDFPKVVLPT LASLRIAAFE EGGKFVGHRI LPVSAIRSGY HYVCLRNEAN QPLCLPALLI 840
  841 YTEASDYIPD DHQDYAEALI NPIKHVSLMD QRARQLAALI GESEAQAGQE TCQDTQSQQL 900
  901 GSQPSSNPTP SPLDASPRRP PGPTTSPAST SLSSPGQRDD LIASILSEVA PTPLDELRGH 960
  961 KALVKLRSRQ ERDLRELRKK HQRKAVTLTR RLLDGLAQAQ AEGRCRLRPG ALGGAADVED1020
 1021 TKEGEDEAKR YQEFQNRQVQ SLLELREAQV DAEAQRRLEH LRQALQRLRE VVLDANTTQF1080
 1081 KRLKEMNERE KKELQKILDR KRHNSISEAK MRDKHKKEAE LTEINRRHIT ESVNSIRRLE1140
 1141 EAQKQRHDRL VAGQQQVLQQ LAEEEPKLLA QLAQECQEQR ARLPQEIRRS LLGEMPEGLG1200
 1201 DGPLVACASN GHAPGSSGHL SGADSESQEE NTQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered Sample pIC145 from april 2005 Okada, M., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..833] PSI-BLAST 1000.0 No description for 2fjuB was found.
    2 View Details [834..1234] PSI-BLAST 9.39794 No description for 2dfsA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.5144141194236 bayes_pls_golite062009
  • protein binding
    		•  1.42613583294271 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  0.585146821573367 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.30853984610622 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle