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Protein Overview: MED12

General Information:
Name(s) found: MED12 [HGNC (HUGO)]
Description(s) found:
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  • gi|4827042|ref|NP_005111.1| mediator of RNA polymerase II transcription, subunit 12 homolog [Homo sapiens] [NCBI NR]
  • gi|4530439|gb|AAD22033.1| thyroid hormone receptor-associated protein complex component TRAP230 [Homo sapiens] [NCBI NR]
  • gi|28558814|sp|Q93074|MED12_HUMAN Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (O [NCBI NR]
  • mediator complex subunit 12 [HGNC (HUGO)]
  • (Q93074) Thyroid hormone receptor-associated protein complex 230 kDa component (Trap230) (Activator-recruited cofactor 240 KDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat containing 11) [Swiss-Prot]
  • Mediator of RNA polymerase II transcription subunit 12 - Homo sapiens (Human) [Swiss-Prot]
  • Thyroid hormone receptor-associated protein complex 230 kDa component [hmr_yeast5_DM3-1_pombe.fasta]
  • trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit); thyroid hormone receptor-associated protein, 230 kDa subunit; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); trinucleotide repeat containing 11 (TH [HMR_022704.fasta]
  • trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit) [Homo sapiens]gi|4530439|gb|AAD22033.1| thyroid hormone receptor-associated protein complex component TRAP230 [Homo sapiens]gi|28558814|sp|Q93074|T230_HUMAN Thyroid hormone rece [nrdb_11152004_Chlamydomonas]
  • Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 KDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleot [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Mediator of RNA polymerase II transcription subunit 12 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005120) trinucleotide repeat containing 11 (THR-associated protein, 230 kD subunit); trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); thyroid hormone receptor-associated protein, 230 kDa subunit [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • thyroid hormone receptor-associated protein complex component TRAP230 [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • mediator of RNA polymerase II transcription, subunit 12 homolog [Homo sapiens] [human-contam-plus-rand.fasta]
  • Tax_Id=9606 THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN COMPLEX 230 KDA COMPONENT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MED12 Mediator of RNA polymerase II transcription subunit 12 [human-ipi-250309-contam.fasta]
  • Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleot [nr-271106-contam.fasta]
  • IPI:IPI00004068.2|SWISS-PROT:Q93074-3|TREMBL:B4DYQ3|ENSEMBL:ENSP00000363215|H-INV:HIT000070117|VEGA:OTTHUMP00000023490 Tax_Id=9606 Gene_Symbol=MED12 Mediator of RNA polymerase II transcription subunit 12 [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Gene_Symbol=MED12 Mediator of RNA polymerase II transcription subunit 12 ENSG00000184634 IPI00004068 IPI00640149 IPI00646093 IPI00745010 IPI00645480 IPI00646174 [drosphohumanreversed.fasta]
    • Organism: Homo sapiens
    Length: 2212 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQSMPSLHT KKILFCYFHL TNSWCLRRYG LGKMAAFGIL SYEHRPLKRP RPRLGPPDVY  60
   61 PQDPKQKEDE LTALNVKQGF NNQPAVSGDE HGSAKNVSFN PAKISSNFSS IIAEKLRCNT 120
  121 LPDTGRRKPQ VNQKDNFWLV TARSQSAINT WFTDLAGTKP LTQLAKKVPI FSKKEEVFGY 180
  181 LAKYTVPVMR AAWLIKMTCA YYAAISETKV KKRHVDPFME WTQIITKYLW EQLQKMAEYY 240
  241 RPGPAGSGGC GSTIGPLPHD VEVAIRQWDY TEKLAMFMFQ DGMLDRHEFL TWVLECFEKI 300
  301 RPGEDELLKL LLPLLLRYSG EFVQSAYLSR RLAYFCTRRL ALQLDGVSSH SSHVISAQST 360
  361 STLPTTPAPQ PPTSSTPSTP FSDLLMCPQH RPLVFGLSCI LQTILLCCPS ALVWHYSLTD 420
  421 SRIKTGSPLD HLPIAPSNLP MPEGNSAFTQ QVRAKLREIE QQIKERGQAV EVRWSFDKCQ 480
  481 EATAGFTIGR VLHTLEVLDS HSFERSDFSN SLDSLCNRIF GLGPSKDGHE ISSDDDAVVS 540
  541 LLCEWAVSCK RSGRHRAMVV AKLLEKRQAE IEAERCGESE AADEKGSIAS GSLSAPSAPI 600
  601 FQDVLLQFLD TQAPMLTDPR SESERVEFFN LVLLFCELIR HDVFSHNMYT CTLISRGDLA 660
  661 FGAPGPRPPS PFDDPADDPE HKEAEGSSSS KLEDPGLSES MDIDPSSSVL FEDMEKPDFS 720
  721 LFSPTMPCEG KGSPSPEKPD VEKEVKPPPK EKIEGTLGVL YDQPRHVQYA THFPIPQEES 780
  781 CSHECNQRLV VLFGVGKQRD DARHAIKKIT KDILKVLNRK GTAETDQLAP IVPLNPGDLT 840
  841 FLGGEDGQKR RRNRPEAFPT AEDIFAKFQH LSHYDQHQVT AQVSRNVLEQ ITSFALGMSY 900
  901 HLPLVQHVQF IFDLMEYSLS ISGLIDFAIQ LLNELSVVEA ELLLKSSDLV GSYTTSLCLC 960
  961 IVAVLRHYHA CLILNQDQMA QVFEGLCGVV KHGMNRSDGS SAERCILAYL YDLYTSCSHL1020
 1021 KNKFGELFSD FCSKVKNTIY CNVEPSESNM RWAPEFMIDT LENPAAHTFT YTGLGKSLSE1080
 1081 NPANRYSFVC NALMHVCVGH HDPDRVNDIA ILCAELTGYC KSLSAEWLGV LKALCCSSNN1140
 1141 GTCGFNDLLC NVDVSDLSFH DSLATFVAIL IARQCLLLED LIRCAAIPSL LNAACSEQDS1200
 1201 EPGARLTCRI LLHLFKTPQL NPCQSDGNKP TVGIRSSCDR HLLAASQNRI VDGAVFAVLK1260
 1261 AVFVLGDAEL KGSGFTVTGG TEELPEEEGG GGSGGRRQGG RNISVETASL DVYAKYVLRS1320
 1321 ICQQEWVGER CLKSLCEDSN DLQDPVLSSA QAQRLMQLIC YPHRLLDNED GENPQRQRIK1380
 1381 RILQNLDQWT MRQSSLELQL MIKQTPNNEM NSLLENIAKA TIEVFQRSAE TGSSSGSTAS1440
 1441 NMPSSSKTKP VLSSLERSGV WLVAPLIAKL PTSVQGHVLK AAGEELEKGQ HLGSSSRKER1500
 1501 DRQKQKSMSL LSQQPFLSLV LTCLKGQDEQ REGLLTSLYS QVHQIVNNWR DDQYLDDCKP1560
 1561 KQLMHEALKL RLNLVGGMFD TVQRSTQQTT EWAMLLLEII ISGTVDMQSN NELFTTVLDM1620
 1621 LSVLINGTLA ADMSSISQGS MEENKRAYMN LAKKLQKELG ERQSDSLEKV RQLLPLPKQT1680
 1681 RDVITCEPQG SLIDTKGNKI AGFDSIFKKE GLQVSTKQKI SPWDLFEGLK PSAPLSWGWF1740
 1741 GTVRVDRRVA RGEEQQRLLL YHTHLRPRPR AYYLEPLPLP PEDEEPPAPT LLEPEKKAPE1800
 1801 PPKTDKPGAA PPSTEERKKK STKGKKRSQP ATKTEDYGMG PGRSGPYGVT VPPDLLHHPN1860
 1861 PGSITHLNYR QGSIGLYTQN QPLPAGGPRV DPYRPVRLPM QKLPTRPTYP GVLPTTMTGV1920
 1921 MGLEPSSYKT SVYRQQQPAV PQGQRLRQQL QQSQGMLGQS SVHQMTPSSS YGLQTSQGYT1980
 1981 PYVSHVGLQQ HTGPAGTMVP PSYSSQPYQS THPSTNPTLV DPTRHLQQRP SGYVHQQAPT2040
 2041 YGHGLTSTQR FSHQTLQQTP MISTMTPMSA QGVQAGVRST AILPEQQQQQ QQQQQQQQQQ2100
 2101 QQQQQQQQQQ QYHIRQQQQQ QILRQQQQQQ QQQQQQQQQQ QQQQQQQQQQ HQQQQQQQAA2160
 2161 PPQPQPQSQP QFQRQGLQQT QQQQQTAALV RQLQQQLSNT QPQPSTNIFG RY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.52

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle