Protein Overview: ARHGEF12

General Information:
Name(s) found:	ARHGEF12 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|7662088\|ref\|NP_056128.1\| Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens] [NCBI NR] gi\|7110160\|gb\|AAF36817.1\| guanine nucleotide exchange factor [Homo sapiens] [NCBI NR] gi\|34395525\|sp\|Q9NZN5.1\|ARHGC_HUMAN RecName: Full=Rho guanine nucleotide exchange factor 12; AltName: Full=Leukemia-associated RhoGEF [NCBI NR] gi\|119587914\|gb\|EAW67510.1\| Rho guanine nucleotide exchange factor (GEF) 12, isoform CRA_c [Homo sapiens] [NCBI NR] Rho guanine nucleotide exchange factor (GEF) 12 [HGNC (HUGO)] Rho guanine nucleotide exchange factor 12 OS=Homo sapiens GN=ARHGEF12 PE=1 SV=1 [Swiss-Prot] (Q9NZN5) Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Swiss-Prot] Guanine nucleotide exchange factor [hmr_yeast5_DM3-1_pombe.fasta] Rho guanine nucleotide exchange factor (GEF) 12; leukemia-associated rho guanine nucleotide exchange factor [HMR_022704.fasta] Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens]gi\|7110160\|gb\|AAF36817.1\| guanine nucleotide exchange factor [Homo sapiens]gi\|34395525\|sp\|Q9NZN5\|ARHC_HUMAN Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [nrdb_11152004_Chlamydomonas] Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform 1 of Rho guanine nucleotide exchange factor 12 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_015313) Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine exchange factor (GEF) 12; leukemia-associated rho guanine nucleotide exchange factor; leukemia-associated rho GEF; similar to mouse Lsc oncogene [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Rho guanine nucleotide exchange factor (GEF) 12; leukemia-associated rho guanine nucleotide exchange factor [Homo sapiens] [HumanGallus06162005.fasta] Rho guanine nucleotide exchange factor (GEF) 12, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] guanine nucleotide exchange factor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 SPLICE ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=ARHGEF12 Isoform 1 of Rho guanine nucleotide exchange factor 12 [human-ipi-250309-contam.fasta] IPI:IPI00022164.3\|SWISS-PROT:Q9NZN5-1\|ENSEMBL:ENSP00000380942\|REFSEQ:NP_056128\|H-INV:HIT000072800 Tax_Id=9606 Gene_Symbol=ARHGEF12 Isoform 1 of Rho guanine nucleotide exchange factor 12 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] rho guanine nucleotide exchange factor 12 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Q9NZN5;O15086;Q6P526; RecName: Full=Rho guanine nucleotide exchange factor 12; AltName: Full=Leukemia-associated RhoGEF; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of Rho guanine nucleotide exchange factor 12 OS=Homo sapiens GN=ARHGEF12 [011711_HMR.fasta] GeneSymbol=ARHGEF12 Synonyms=DKFZp686O2372\|KIAA0382\|LARG\|PRO2792 rho guanine nucleotide exchange factor 12 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00022164.3\|SWISS-PROT:Q9NZN5-1\|ENSEMBL:ENSP00000380942\|REFSEQ:NP_056128\|H-INV:HIT000072800\|VEGA:OTTHUMP00000231993 Tax_Id=9606 Gene_Symbol=ARHGEF12 Isoform 1 of Rho guanine nucleotide exchange factor 12 [ipi.HUMAN.20110912.fasta] Rho guanine nucleotide exchange factor 12 GN=ARHGEF12 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	1544 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERIA SHDFDPTDSS SKKTKSSSEE  60
   61 SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT 120
  121 LVTHSNHLEV VKLIKSGSYV ALTVQGRPPG SPQIPLADSE VEPSVIGHMS PIMTSPHSPG 180
  181 ASGNMERITS PVLMGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT PAQRLLKEIQ 240
  241 EAKKHIPQLQ EQLSKATGSA QDGAVVTPSR PLGDTLTVSE AETDPGDVLG RTDCSSGDAS 300
  301 RPSSDNADSP KSGPKERIYL EENPEKSETI QDTDTQSLVG SPSTRIAPHI IGAEDDDFGT 360
  361 EHEQINGQCS CFQSIELLKS RPAHLAVFLH HVVSQFDPAT LLCYLYSDLY KHTNSKETRR 420
  421 IFLEFHQFFL DRSAHLKVSV PDEMSADLEK RRPELIPEDL HRHYIQTMQE RVHPEVQRHL 480
  481 EDFRQKRSMG LTLAESELTK LDAERDKDRL TLEKERTCAE QIVAKIEEVL MTAQAVEEDK 540
  541 SSTMQYVILM YMKHLGVKVK EPRNLEHKRG RIGFLPKIKQ SMKKDKEGEE KGKRRGFPSI 600
  601 LGPPRRPSRH DNSAIGRAME LQKARHPKHL STPSSVSPEP QDSAKLRQSG LANEGTDAGY 660
  661 LPANSMSSVA SGASFSQEGG KENDTGSKQV GETSAPGDTL DGTPRTLNTV FDFPPPPLDQ 720
  721 VQEEECEVER VTEHGTPKPF RKFDSVAFGE SQSEDEQFEN DLETDPPNWQ QLVSREVLLG 780
  781 LKPCEIKRQE VINELFYTER AHVRTLKVLD QVFYQRVSRE GILSPSELRK IFSNLEDILQ 840
  841 LHIGLNEQMK AVRKRNETSV IDQIGEDLLT WFSGPGEEKL KHAAATFCSN QPFALEMIKS 900
  901 RQKKDSRFQT FVQDAESNPL CRRLQLKDII PTQMQRLTKY PLLLDNIAKY TEWPTEREKV 960
  961 KKAADHCRQI LNYVNQAVKE AENKQRLEDY QRRLDTSSLK LSEYPNVEEL RNLDLTKRKM1020
 1021 IHEGPLVWKV NRDKTIDLYT LLLEDILVLL QKQDDRLVLR CHSKILASTA DSKHTFSPVI1080
 1081 KLSTVLVRQV ATDNKALFVI SMSDNGAQIY ELVAQTVSEK TVWQDLICRM AASVKEQSTK1140
 1141 PIPLPQSTPG EGDNDEEDPS KLKEEQHGIS VTGLQSPDRD LGLESTLISS KPQSHSLSTS1200
 1201 GKSEVRDLFV AERQFAKEQH TDGTLKEVGE DYQIAIPDSH LPVSEERWAL DALRNLGLLK1260
 1261 QLLVQQLGLT EKSVQEDWQH FPRYRTASQG PQTDSVIQNS ENIKAYHSGE GHMPFRTGTG1320
 1321 DIATCYSPRT STESFAPRDS VGLAPQDSQA SNILVMDHMI MTPEMPTMEP EGGLDDSGEH1380
 1381 FFDAREAHSD ENPSEGDGAV NKEEKDVNLR ISGNYLILDG YDPVQESSTD EEVASSLTLQ1440
 1441 PMTGIPAVES THQQQHSPQN THSDGAISPF TPEFLVQQRW GAMEYSCFEI QSPSSCADSQ1500
 1501 SQIMEYIHKI EADLEHLKKV EESYTILCQR LAGSALTDKH SDKS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	Sample pIC145 from april 2005	Okada, M., et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: ARHGEF12

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: