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Protein Overview: IQGAP1

General Information:
Name(s) found: IQGAP1 [HGNC (HUGO)]
Description(s) found:
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  • pir||A54854 Ras GTPase activating protein-related protein - human [NCBI NR]
  • gi|536844|gb|AAA59187.1| ras GTPase-activating-like protein [NCBI NR]
  • gi|4506787|ref|NP_003861.1| IQ motif containing GTPase activating protein 1 [Homo sapiens] [NCBI NR]
  • gi|156230796|gb|AAI51835.1| IQ motif containing GTPase activating protein 1 [Homo sapiens] [NCBI NR]
  • gi|119622508|gb|EAX02103.1| hCG1991735, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119622507|gb|EAX02102.1| hCG1991735, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|1170586|sp|P46940.1|IQGA1_HUMAN RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195 [NCBI NR]
  • IQ motif containing GTPase activating protein 1 [HGNC (HUGO)]
  • Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 PE=1 SV=1 [Swiss-Prot]
  • (P46940) Ras GTPase-activating-like protein IQGAP1 (p195) [Swiss-Prot]
  • Ras GTPase-activating-like protein IQGAP1 [hmr_yeast5_DM3-1_pombe.fasta]
  • IQ motif containing GTPase activating protein 1; rasGAP-like with IQ motifs; RASGAP-like with IQ motifs (sar1, S. pombe, homolog of) [HMR_022704.fasta]
  • IQ motif containing GTPase activating protein 1 [Homo sapiens]gi|1170586|sp|P46940|IQG1_HUMAN Ras GTPase-activating-like protein IQGAP1 (P195)gi|627594|pir||A54854 Ras GTPase activating protein-related protein - humangi|536844|gb|AAA59187.1| ras GTPase [nrdb_11152004_Chlamydomonas]
  • Ras GTPase-activating-like protein IQGAP1 (p195) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Ras GTPase-activating-like protein IQGAP1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003870) IQ motif containing GTPase activating protein 1; rasGAP-like with IQ motifs; RASGAP-like with IQ motifs (sar1, S. pombe, homolog of) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • IQ motif containing GTPase activating protein 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • IQ motif containing GTPase activating protein 1; rasGAP-like with IQ motifs; RASGAP-like with IQ motifs (sar1, S. pombe, homolog of) [Homo sapiens] [HumanGallus06162005.fasta]
  • hCG1991735, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ras GTPase-activating-like protein [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=IQGAP1 Ras GTPase-activating-like protein IQGAP1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00009342.1|SWISS-PROT:P46940|TREMBL:A4QPB0;A7MBM3;B4DNP4;B4E2M0;Q05DN7;Q5FWG8;Q6P1N4;Q96PA3|ENSEMBL:ENSP00000268182|REFSEQ:NP_003861|H-INV:HIT000193089|VEGA:OTTHUMP00000176675;OTTHUMP00000194748 Tax_Id=9606 Gene_Symbol=IQGAP1 Ras GTPase-activating- [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=IQGAP1 Ras GTPase-activating-like protein IQGAP1 ENSG00000140575 IPI00009342 [drosphohumanreversed.fasta]
  • ras GTPase-activating-like protein IQGAP1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P46940;A7MBM3; RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens GN=IQGAP1 [011711_HMR.fasta]
  • IPI:IPI00009342.1|SWISS-PROT:P46940|TREMBL:A4QPB0;B4DNP4;B4E2M0;Q05DN7;Q5FWG8;Q6P1N4;Q96PA3|ENSEMBL:ENSP00000268182|REFSEQ:NP_003861|H-INV:HIT000193089|VEGA:OTTHUMP00000176675;OTTHUMP00000194748 Tax_Id=9606 Gene_Symbol=IQGAP1 Ras GTPase-activating-like protein IQGAP1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=IQGAP1 Synonyms=HUMORFA01|KIAA0051|SAR1|p195 ras GTPase-activating-like protein IQGAP1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00009342.1|SWISS-PROT:P46940|TREMBL:A4QPB0;B4DNP4;B4E2M0;F5H7A1;Q05DN7;Q5FWG8;Q6P1N4;Q96PA3|ENSEMBL:ENSP00000268182|REFSEQ:NP_003861|H-INV:HIT000193089|VEGA:OTTHUMP00000194748 Tax_Id=9606 Gene_Symbol=IQGAP1 Ras GTPase-activating-like protein IQGAP1 [ipi.HUMAN.20110912.fasta]
  • Ras GTPase-activating-like protein IQGAP1 GN=IQGAP1 [Doctor+uniprot-HUMAN-120911.fasta]
  • HCG1991735, isoform CRA_a OS=Homo sapiens GN=hCG_1991735 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 1657 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAADEVDGL GVARPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE  60
   61 DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL 120
  121 NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE 180
  181 EINNMKTELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDR RIPADTFAAL 240
  241 KNPNAMLVNL EEPLASTYQD ILYQAKQDKM TNAKNRTENS ERERDVYEEL LTQAEIQGNI 300
  301 NKVNTFSALA NIDLALEQGD ALALFRALQS PALGLRGLQQ QNSDWYLKQL LSDKQQKRQS 360
  361 GQTDPLQKEE LQSGVDAANS AAQQYQRRLA AVALINAAIQ KGVAEKTVLE LMNPEAQLPQ 420
  421 VYPFAADLYQ KELATLQRQS PEHNLTHPEL SVAVEMLSSV ALINRALESG DVNTVWKQLS 480
  481 SSVTGLTNIE EENCQRYLDE LMKLKAQAHA ENNEFITWND IQACVDHVNL VVQEEHERIL 540
  541 AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQEIQDESAV 600
  601 LWLDEIQGGI WQSNKDTQEA QKFALGIFAI NEAVESGDVG KTLSALRSPD VGLYGVIPEC 660
  661 GETYHSDLAE AKKKKLAVGD NNSKWVKHWV KGGYYYYHNL ETQEGGWDEP PNFVQNSMQL 720
  721 SREEIQSSIS GVTAAYNREQ LWLANEGLIT RLQARCRGYL VRQEFRSRMN FLKKQIPAIT 780
  781 CIQSQWRGYK QKKAYQDRLA YLRSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII 840
  841 KIQAFIRANK ARDDYKTLIN AEDPPMVVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI 900
  901 RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM INKQKGGLKA 960
  961 LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY1020
 1021 LLLRLFKTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM1080
 1081 DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALAHEEVKTR LDSSIRNMRA1140
 1141 VTDKFLSAIV SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI1200
 1201 VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI INEYLSQSYQ1260
 1261 KFRRFFQTAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH1320
 1321 NDPIHELLDD LGEVPTIESL IGESSGNLND PNKEALAKTE VSLTLTNKFD VPGDENAEMD1380
 1381 ARTILLNTKR LIVDVIRFQP GETLTEILET PATSEQEAEH QRAMQRRAIR DAKTPDKMKK1440
 1441 SKSVKEDSNL TLQEKKEKIQ TGLKKLTELG TVDPKNKYQE LINDIARDIR NQRRYRQRRK1500
 1501 AELVKLQQTY AALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS1560
 1561 LKYTAARLHE KGVLLEIEDL QVNQFKNVIF EISPTEEVGD FEVKAKFMGV QMETFMLHYQ1620
 1621 DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL NKKFYGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle