Protein Overview: PLD1

General Information:
Name(s) found:	PLD1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|46362479\|gb\|AAH68976.1\| Phospholipase D1, phosphatidylcholine-specific [Homo sapiens] [NCBI NR] gi\|4505873\|ref\|NP_002653.1\| phospholipase D1 isoform a [Homo sapiens] [NCBI NR] gi\|2499703\|sp\|Q13393.1\|PLD1_HUMAN RecName: Full=Phospholipase D1; Short=PLD 1; Short=hPLD1; AltName: Full=Choline phosphatase 1; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D1 [NCBI NR] gi\|119598886\|gb\|EAW78480.1\| phospholipase D1, phosphatidylcholine-specific [Homo sapiens] [NCBI NR] gi\|1185463\|gb\|AAB49031.1\| phospholipase D1 [NCBI NR] phospholipase D1, phosphatidylcholine-specific [HGNC (HUGO)] Phospholipase D1 OS=Homo sapiens GN=PLD1 PE=1 SV=1 [Swiss-Prot] Splice isoform PLD1A of Q13393 [hmr_yeast5_DM3-1_pombe.fasta] phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific [HMR_022704.fasta] phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific; phospholipase D1, phophatidylcholine-specific (NOTE: redefinition of symbol) [071204_hmrz_cont.fasta] phospholipase D1, phophatidylcholine-specific [Homo sapiens]gi\|46362479\|gb\|AAH68976.1\| Phospholipase D1, phophatidylcholine-specific [Homo sapiens]gi\|2499703\|sp\|Q13393\|PLD1_HUMAN Phospholipase D1 (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydr [nrdb_11152004_Chlamydomonas] Phospholipase D1 (PLD 1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) (hPLD1) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Splice Isoform PLD1A of Phospholipase D1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_002662) phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] phospholipase D1, phophatidylcholine-specific [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific; phospholipase D1, phophatidylcholine-specific (NOTE: redefinition of symbol) [Homo sapiens] [HumanGallus06162005.fasta] phospholipase D1, phophatidylcholine-specific; phospholipase D1, phosphatidylcholine-specific [Homo sapiens] [human-NCBI-042104-rand.fasta] phospholipase D1, phophatidylcholine-specific isoform a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Phospholipase D1 (PLD 1) (hPLD1) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] phospholipase D1, phosphatidylcholine-specific [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Phospholipase D1, phosphatidylcholine-specific [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] phospholipase D1 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform PLD1A of Phospholipase D1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 SPLICE ISOFORM 1 OF PHOSPHOLIPASE D1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Phospholipase D1; Short=PLD 1; Short=hPLD1; AltName: Full=Choline phosphatase 1; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D1 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=PLD1 Isoform PLD1A of Phospholipase D1 [human-ipi-250309-contam.fasta] phospholipase D1 isoform a [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta] IPI:IPI00012865.1\|SWISS-PROT:Q13393-1\|TREMBL:Q59EA4\|ENSEMBL:ENSP00000342793\|REFSEQ:NP_002653\|H-INV:HIT000263171\|VEGA:OTTHUMP00000173567;OTTHUMP00000211094 Tax_Id=9606 Gene_Symbol=PLD1 Isoform PLD1A of Phospholipase D1 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=PLD1 Isoform PLD1A of Phospholipase D1 ENSG00000075651 IPI00218798 IPI00218799 IPI00012865 IPI00218797 IPI00791503 IPI00793302 IPI00790110 [drosphohumanreversed.fasta] Q13393; RecName: Full=Phospholipase D1; AltName: Full=Choline phosphatase 1; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform PLD1A of Phospholipase D1 OS=Homo sapiens GN=PLD1 [011711_HMR.fasta] GeneSymbol=PLD1 Synonyms=- phospholipase D1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00012865.1\|SWISS-PROT:Q13393-1\|TREMBL:Q59EA4\|ENSEMBL:ENSP00000342793\|REFSEQ:NP_002653\|H-INV:HIT000263171\|VEGA:OTTHUMP00000211094 Tax_Id=9606 Gene_Symbol=PLD1 Isoform PLD1A of Phospholipase D1 [ipi.HUMAN.20110912.fasta] Phospholipase D1 GN=PLD1 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	1074 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA  60
   61 IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFKWQVKRKF 120
  121 KHFQEFHREL LKYKAFIRIP IPTRRHTFRR QNVREEPREM PSLPRSSENM IREEQFLGRR 180
  181 KQLEDYLTKI LKMPMYRNYH ATTEFLDISQ LSFIHDLGPK GIEGMIMKRS GGHRIPGLNC 240
  241 CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE TETKYGIRID 300
  301 NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHRF GSYAAIQENA LAKWYVNAKG 360
  361 YFEDVANAME EANEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 420
  421 KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSTVYL WAHHEKLVII DQSVAFVGGI 480
  481 DLAYGRWDDN EHRLTDVGSV KRVTSGPSLG SLPPAAMESM ESLRLKDKNE PVQNLPIQKS 540
  541 IDDVDSKLKG IGKPRKFSKF SLYKQLHRHH LHDADSISSI DSTSSYFNHY RSHHNLIHGL 600
  601 KPHFKLFHPS SESEQGLTRP HADTGSIRSL QTGVGELHGE TRFWHGKDYC NFVFKDWVQL 660
  661 DKPFADFIDR YSTPRMPWHD IASAVHGKAA RDVARHFIQR WNFTKIMKSK YRSLSYPFLL 720
  721 PKSQTTAHEL RYQVPGSVHA NVQLLRSAAD WSAGIKYHEE SIHAAYVHVI ENSRHYIYIE 780
  781 NQFFISCADD KVVFNKIGDA IAQRILKAHR ENQKYRVYVV IPLLPGFEGD ISTGGGNALQ 840
  841 AIMHFNYRTM CRGENSILGQ LKAELGNQWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL 900
  901 IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FARGLRLQCF 960
  961 RVVLGYLDDP SEDIQDPVSD KFFKEVWVST AARNATIYDK VFRCLPNDEV HNLIQLRDFI1020
 1021 NKPVLAKEDP IRAEEELKKI RGFLVQFPFY FLSEESLLPS VGTKEAIVPM EVWT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MIS12	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..78]	deduced	N/A	No confident structure predictions are available.
2	View Details	[79..230]	PSI-BLAST	24.30103	crystal structure of CISK-PX domain
3	View Details	[231..339]	PSI-BLAST	4.69897	No description for 2dn6A was found.
4	View Details	[340..529]	PSI-BLAST	10.39794	Nuclease Nuc
5	View Details	[530..966]	PSI-BLAST	17.39794	Phospholipase D
6	View Details	[967..1074]	deduced	N/A	Confident ab initio structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PLD1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: