Protein Overview: PLK1

General Information:
Name(s) found:	PLK1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	pir\|\|S34130 serine/threonine-specific protein kinase PLK (EC 2.7.1.-) - human [NCBI NR] gi\|312998\|emb\|CAA51837.1\| protein kinase [Homo sapiens] [NCBI NR] gi\|21359873\|ref\|NP_005021.2\| polo-like kinase 1 [Homo sapiens] [NCBI NR] gi\|1709658\|sp\|P53350.1\|PLK1_HUMAN RecName: Full=Serine/threonine-protein kinase PLK1; AltName: Full=Polo-like kinase 1; Short=PLK-1; AltName: Full=Serine/threonine-protein kinase 13; Short=STPK13 [NCBI NR] gi\|15928776\|gb\|AAH14846.1\| Polo-like kinase 1 (Drosophila) [Homo sapiens] [NCBI NR] gi\|12804287\|gb\|AAH03002.1\| Polo-like kinase 1 (Drosophila) [Homo sapiens] [NCBI NR] gi\|12803131\|gb\|AAH02369.1\| Polo-like kinase 1 (Drosophila) [Homo sapiens] [NCBI NR] gi\|119576207\|gb\|EAW55803.1\| polo-like kinase 1 (Drosophila), isoform CRA_a [Homo sapiens] [NCBI NR] polo-like kinase 1 (Drosophila) [HGNC (HUGO)] Serine/threonine-protein kinase PLK1 OS=Homo sapiens GN=PLK1 PE=1 SV=1 [Swiss-Prot] Serine/threonine-protein kinase PLK [hmr_yeast5_DM3-1_pombe.fasta] polo-like kinase; polo (Drosophia)-like kinase; polo-like kinase (Drosophila) [HMR_022704.fasta] polo-like kinase [Homo sapiens]gi\|15928776\|gb\|AAH14846.1\| Polo-like kinase [Homo sapiens]gi\|12803131\|gb\|AAH02369.1\| Polo-like kinase [Homo sapiens]gi\|12804287\|gb\|AAH03002.1\| Polo-like kinase [Homo sapiens]gi\|423046\|pir\|\|S34130 serine/threonine-specifi [nrdb_11152004_Chlamydomonas] Serine/threonine-protein kinase PLK1 (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Serine/threonine-protein kinase PLK1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_005030) polo-like kinase; polo (Drosophia)-like kinase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] polo-like kinase [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] polo-like kinase; polo (Drosophia)-like kinase; polo-like kinase (Drosophila) [Homo sapiens] [HumanGallus06162005.fasta] polo-like kinase 1 (Drosophila), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Polo-like kinase 1 (Drosophila) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] protein kinase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 SERINE/THREONINE-PROTEIN KINASE PLK1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=PLK1 Serine/threonine-protein kinase PLK1 [human-ipi-250309-contam.fasta] polo-like kinase 1 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta] IPI:IPI00021248.1\|SWISS-PROT:P53350\|TREMBL:B2R841;B4E083\|ENSEMBL:ENSP00000300093\|REFSEQ:NP_005021\|H-INV:HIT000030836\|VEGA:OTTHUMP00000081380;OTTHUMP00000122462 Tax_Id=9606 Gene_Symbol=PLK1 Serine/threonine-protein kinase PLK1 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=PLK1 Serine/threonine-protein kinase PLK1 ENSG00000166851 IPI00021248 IPI00455896 IPI00556429 [drosphohumanreversed.fasta] serine/threonine-protein kinase PLK1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] P53350;Q15153;Q99746; RecName: Full=Serine/threonine-protein kinase PLK1; AltName: Full=Polo-like kinase 1; AltName: Full=Serine/threonine-protein kinase 13; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Serine/threonine-protein kinase PLK1 OS=Homo sapiens GN=PLK1 [011711_HMR.fasta] GeneSymbol=PLK1 Synonyms=PLK\|STPK13 serine/threonine-protein kinase PLK1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00021248.1\|SWISS-PROT:P53350\|TREMBL:B2R841\|ENSEMBL:ENSP00000300093\|REFSEQ:NP_005021\|H-INV:HIT000030836\|VEGA:OTTHUMP00000122462 Tax_Id=9606 Gene_Symbol=PLK1 Serine/threonine-protein kinase PLK1 [ipi.HUMAN.20110912.fasta] Serine/threonine-protein kinase PLK1 GN=PLK1 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	603 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAVTAGKL ARAPADPGKA GVPGVAAPGA PAAAPPAKEI PEVLVDPRSR RRYVRGRFLG  60
   61 KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQREKMSM EISIHRSLAH QHVVGFHGFF 120
  121 EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQI VLGCQYLHRN RVIHRDLKLG 180
  181 NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI 240
  241 MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQTDP TARPTINELL 300
  301 NDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSNRKPL TVLNKGLENP LPERPREKEE 360
  361 PVVRETGEVV DCHLSDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK 420
  421 YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVSSHPN SLMKKITLLK 480
  481 YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGSV QINFFQDHTK 540
  541 LILCPLMAAV TYIDEKRDFR TYRLSLLEEY GCCKELASRL RYARTMVDKL LSSRSASNRL 600
  601 KAS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	Sample pIC145 from april 2005	Okada, M., et al. (2006)
View Run	None Entered	Sample pIC146 from april 2005	Okada, M., et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..344]	PSI-BLAST	68.221849	No description for 2ou7A was found.
2	View Details	[345..508]	FFAS03	8.7	The polo-box domain of Plk1 in complex with a phospho-peptide
3	View Details	[509..603]	PSI-BLAST	69.221849	The polo-box domain of Plk1 in complex with a phospho-peptide

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.85

Protein Overview: PLK1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: