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Protein Overview: HAGH

General Information:
Name(s) found: HAGH [HGNC (HUGO)]
Description(s) found:
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  • gi|94538320|ref|NP_001035517.1| hydroxyacylglutathione hydrolase isoform 2 [Homo sapiens] [NCBI NR]
  • gi|6137440|pdb|1QH5|B Chain B, Human Glyoxalase Ii With S-(N-Hydroxy-N- Bromophenylcarbamoyl)glutathione [NCBI NR]
  • gi|6137439|pdb|1QH5|A Chain A, Human Glyoxalase Ii With S-(N-Hydroxy-N- Bromophenylcarbamoyl)glutathione [NCBI NR]
  • gi|6137438|pdb|1QH3|B Chain B, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site [NCBI NR]
  • gi|6137437|pdb|1QH3|A Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site [NCBI NR]
  • gi|4885389|ref|NP_005317.1| hydroxyacyl glutathione hydrolase [Homo sapiens] [NCBI NR]
  • gi|2494849|sp|Q16775.1|GLO2_HUMAN RecName: Full=Hydroxyacylglutathione hydrolase; AltName: Full=Glyoxalase II; Short=Glx II [NCBI NR]
  • gi|14336766|gb|AAK61294.1|AE006639_8 hydroxyacylglutathione hydrolase [Homo sapiens] [NCBI NR]
  • gi|12803585|gb|AAH02627.1| Hydroxyacyl glutathione hydrolase [Homo sapiens] [NCBI NR]
  • gi|12654065|gb|AAH00840.1| Hydroxyacylglutathione hydrolase [Homo sapiens] [NCBI NR]
  • gi|1237213|emb|CAA62483.1| glyoxalase II [Homo sapiens] [NCBI NR]
  • emb|CAC14021.1| C429E7.1 (hydroxyacyl glutathione hydrolase) [Homo sapiens] [NCBI NR]
  • gi|119606015|gb|EAW85609.1| hydroxyacylglutathione hydrolase, isoform CRA_a [Homo sapiens] [NCBI NR]
  • hydroxyacylglutathione hydrolase [HGNC (HUGO)]
  • Hydroxyacylglutathione hydrolase OS=Homo sapiens GN=HAGH PE=1 SV=1 [Swiss-Prot]
  • Hydroxyacylglutathione hydrolase [hmr_yeast5_DM3-1_pombe.fasta]
  • hydroxyacyl glutathione hydrolase; Hydroxyacyl glutathione hydrolase; glyoxalase II; hydroxyacyl glutathione hydrolase; glyoxalase 2; hydroxyacylglutathione hydroxylase [HMR_022704.fasta]
  • hydroxyacyl glutathione hydrolase; hydroxyacylglutathione hydroxylase; Hydroxyacyl glutathione hydrolase; glyoxalase II; hydroxyacyl glutathione hydrolase; glyoxalase 2 [Human2242005.fasta]
  • hydroxyacyl glutathione hydrolase [Homo sapiens]gi|12654065|gb|AAH00840.1| Hydroxyacyl glutathione hydrolase [Homo sapiens]gi|14336766|gb|AAK61294.1| hydroxyacylglutathione hydrolase [Homo sapiens]gi|12803585|gb|AAH02627.1| Hydroxyacyl glutathione hydr [nrdb_11152004_Chlamydomonas]
  • Hydroxyacylglutathione hydrolase (Glyoxalase II) (GLX II) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Hydroxyacylglutathione hydrolase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005326) hydroxyacyl glutathione hydrolase; hydroxyacyl glutathione hydrolase; glyoxalase 2; Hydroxyacyl glutathione hydrolase; glyoxalase II; hydroxyacylglutathione hydroxylase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • hydroxyacyl glutathione hydrolase isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • hydroxyacyl glutathione hydrolase; hydroxyacylglutathione hydroxylase; Hydroxyacyl glutathione hydrolase; glyoxalase II; hydroxyacyl glutathione hydrolase; glyoxalase 2 [Homo sapiens] [HumanGallus06162005.fasta]
  • hydroxyacyl glutathione hydrolase; Hydroxyacyl glutathione hydrolase; glyoxalase II; hydroxyacyl glutathione hydrolase; glyoxalase 2; hydroxyacylglutathione hydroxylase [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Chain B, Human Glyoxalase Ii With S-(N-Hydroxy-N- Bromophenylcarbamoyl)glutathione [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Glyoxalase Ii With S-(N-Hydroxy-N- Bromophenylcarbamoyl)glutathione [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Hydroxyacylglutathione hydrolase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hydroxyacylglutathione hydrolase, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • glyoxalase II [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hydroxyacylglutathione hydrolase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 HYDROXYACYLGLUTATHIONE HYDROLASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=HAGH Hydroxyacylglutathione hydrolase [human-ipi-250309-contam.fasta]
  • hydroxyacylglutathione hydrolase isoform 2 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • Hydroxyacyl glutathione hydrolase [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00745553.1|SWISS-PROT:Q16775|ENSEMBL:ENSP00000262303;ENSP00000380511|REFSEQ:NP_001035517|VEGA:OTTHUMP00000158840 Tax_Id=9606 Gene_Symbol=HAGH Hydroxyacylglutathione hydrolase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=HAGH Isoform 2 of Hydroxyacylglutathione hydrolase, mitochondrial [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • hydroxyacylglutathione hydrolase, mitochondrial isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Isoform 2 of Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens GN=HAGH [011711_HMR.fasta]
  • IPI:IPI00745553.1|SWISS-PROT:Q16775-2|ENSEMBL:ENSP00000262303;ENSP00000380511|REFSEQ:NP_001035517|VEGA:OTTHUMP00000158840 Tax_Id=9606 Gene_Symbol=HAGH Isoform 2 of Hydroxyacylglutathione hydrolase, mitochondrial [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=HAGH Synonyms=GLO2|GLX2|GLXII|HAGH1 hydroxyacylglutathione hydrolase, mitochondrial isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00745553.1|SWISS-PROT:Q16775-2|ENSEMBL:ENSP00000380511|REFSEQ:NP_001035517|VEGA:OTTHUMP00000158840 Tax_Id=9606 Gene_Symbol=HAGH Isoform 2 of Hydroxyacylglutathione hydrolase, mitochondrial [ipi.HUMAN.20110912.fasta]
  • Isoform 2 of Hydroxyacylglutathione hydrolase, mitochondrial GN=HAGH [Doctor+uniprot-HUMAN-120911.fasta]
  • Isoform of Q16775, Isoform 2 of Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens GN=HAGH [2016-04-human-contam-aPKC-His-Par6.fasta]
    • Organism: Homo sapiens
    Length: 260 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVEVLPALT DNYMYLVIDD ETKEAAIVDP VQPQKVVDAA RKHGVKLTTV LTTHHHWDHA  60
   61 GGNEKLVKLE SGLKVYGGDD RIGALTHKIT HLSTLQVGSL NVKCLATPCH TSGHICYFVS 120
  121 KPGGSEPPAV FTGDTLFVAG CGKFYEGTAD EMCKALLEVL GRLPPDTRVY CGHEYTINNL 180
  181 KFARHVEPGN AAIREKLAWA KEKYSIGEPT VPSTLAEEFT YNPFMRVREK TVQQHAGETD 240
  241 PVTTMRAVRR EKDQFKMPRD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..260] PSI-BLAST 64.0 Glyoxalase II (hydroxyacylglutathione hydrolase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydroxyacylglutathione hydrolase activity
    		•  3.53012507604564 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • binding
    		•  0.900972948435178 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  0.802604883362264 bayes_pls_golite062009
  • hydrolase activity
    		•  0.021392930321391 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle