Protein Overview: UBR5

General Information:
Name(s) found:	UBR5 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|20137621\|sp\|O95071.2\|UBR5_HUMAN RecName: Full=E3 ubiquitin-protein ligase UBR5; AltName: Full=E3 ubiquitin-protein ligase, HECT domain-containing 1; AltName: Full=Hyperplastic discs protein homolog; Short=hHYD; AltName: Full=Progestin-induced protein [NCBI NR] gi\|187951631\|gb\|AAI37235.1\| Ubiquitin protein ligase E3 component n-recognin 5 [Homo sapiens] [NCBI NR] gi\|15147337\|ref\|NP_056986.2\| ubiquitin protein ligase E3 component n-recognin 5 [Homo sapiens] [NCBI NR] gi\|15029597\|gb\|AAD01259.2\| progestin induced protein [Homo sapiens] [NCBI NR] ubiquitin protein ligase E3 component n-recognin 5 [HGNC (HUGO)] E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens GN=UBR5 PE=1 SV=2 [Swiss-Prot] (O95071) Ubiquitin--protein ligase EDD (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) [Swiss-Prot] E3 ubiquitin-protein ligase EDD1 - Homo sapiens (Human) [Swiss-Prot] Ubiquitin--protein ligase EDD [hmr_yeast5_DM3-1_pombe.fasta] progestin-induced protein; ubiquitin-protein ligase; hyperplastic discs protein homolog [HMR_022704.fasta] progestin-induced protein; ubiquitin-protein ligase; hyperplastic discs protein homolog; progestin induced protein [071204_hmrz_cont.fasta] progestin-induced protein [Homo sapiens]gi\|15029597\|gb\|AAD01259.2\| progestin induced protein [Homo sapiens]gi\|20137621\|sp\|O95071\|EDD_HUMAN Ubiquitin--protein ligase EDD (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) [nrdb_11152004_Chlamydomonas] Ubiquitin--protein ligase EDD1 (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 Ubiquitin-protein ligase EDD1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_015902) progestin induced protein; ubiquitin-protein ligase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] E3 ubiquitin protein ligase, HECT domain containing, 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Tax_Id=9606 Ubiquitin--protein ligase EDD1 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta] Tax_Id=9606 Ubiquitin--protein ligase EDD [EBI-IPI_human_3.04_03-07-2005_reverse.fasta] progestin-induced protein; ubiquitin-protein ligase; hyperplastic discs protein homolog; progestin induced protein [Homo sapiens] [HumanGallus06162005.fasta] progestin-induced protein; ubiquitin-protein ligase; hyperplastic discs protein homolog [Homo sapiens] [human-NCBI-042104-rand.fasta] Tax_Id=9606 Ubiquitin--protein ligase EDD [EBI-IPI_Drosophila_na_12-13-2007_con_reversed.fasta] E3 ubiquitin-protein ligase UBR5 (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Ubiquitin protein ligase E3 component n-recognin 5 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] ubiquitin protein ligase E3 component n-recognin 5 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] progestin induced protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 UBIQUITIN--PROTEIN LIGASE EDD [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=UBR5 E3 ubiquitin-protein ligase UBR5 [human-ipi-250309-contam.fasta] Ubiquitin-protein ligase EDD1 (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein) [nr-271106-contam.fasta] IPI:IPI00026320.1\|SWISS-PROT:O95071\|TREMBL:B3KML2;Q49A65\|ENSEMBL:ENSP00000220959\|REFSEQ:NP_056986\|H-INV:HIT000061808\|VEGA:OTTHUMP00000178177 Tax_Id=9606 Gene_Symbol=UBR5 E3 ubiquitin-protein ligase UBR5 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=UBR5 E3 ubiquitin-protein ligase EDD1 ENSG00000104517 IPI00783232 IPI00026320 [drosphohumanreversed.fasta] Tax_Id=9606 Gene_Symbol=UBR5 E3 ubiquitin-protein ligase EDD1 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta] E3 ubiquitin-protein ligase UBR5 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] O95071;B2RP24;O94970;Q9NPL3; RecName: Full=E3 ubiquitin-protein ligase UBR5; AltName: Full=E3 ubiquitin-protein ligase, HECT domain-containing 1; AltName: Full=Hyperplastic discs protein homolog; AltName: Full=Progestin-induced protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens GN=UBR5 [011711_HMR.fasta] GeneSymbol=UBR5 Synonyms=DD5\|EDD\|EDD1\|FLJ11310\|HYD\|KIAA0896\|MGC57263 E3 ubiquitin-protein ligase UBR5 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00026320.1\|SWISS-PROT:O95071\|TREMBL:B3KML2\|ENSEMBL:ENSP00000429084\|REFSEQ:NP_056986\|VEGA:OTTHUMP00000227389 Tax_Id=9606 Gene_Symbol=UBR5 E3 ubiquitin-protein ligase UBR5 [ipi.HUMAN.20110912.fasta] E3 ubiquitin-protein ligase UBR5 GN=UBR5 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	2799 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF  60
   61 LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR TSRPGRTSDS PWFLSGSETL 120
  121 GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI 180
  181 PASVIPEELI SQAQVVLQGK SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE 240
  241 SYLPGEDLMS LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP 300
  301 LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE PNLDKKNTPV QSPVSLGEDL 360
  361 QWWPDKDGTK FICIGALYSE LLAVSSKGEL YQWKWSESEP YRNAQNPSLH HPRATFLGLT 420
  421 NEKIVLLSAN SIRATVATEN NKVATWVDET LSSVASKLEH TAQTYSELQG ERIVSLHCCA 480
  481 LYTCAQLENS LYWWGVVPFS QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP 540
  541 LYHAGAVAFS ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKNMEKASK TTEAKPESKQ 600
  601 EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP KEEEKVNEEQ WSLREVVFVE 660
  661 DVKNVPVGKV LKVDGAYVAV KFPGTSSNTN CQNSSGPDAD PSSLLQDCRL LRIDELQVVK 720
  721 TGGTPKVPDC FQRTPKKLCI PEKTEILAVN VDSKGVHAVL KTGNWVRYCI FDLATGKAEQ 780
  781 ENNFPTSSIA FLGQNERNVA IFTAGQESPI ILRDGNGTIY PMAKDCMGGI RDPDWLDLPP 840
  841 ISSLGMGVHS LINLPANSTI KKKAAVIIMA VEKQTLMQHI LRCDYEACRQ YLMNLEQAVV 900
  901 LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN TFAERLSAVE 960
  961 AIANAISVVS SNGPGNRAGS SSSRSLRLRE MMRRSLRAAG LGRHEAGASS SDHQDPVSPP1020
 1021 IAPPSWVPDP PAMDPDGDID FILAPAVGSL TTAATGTGQG PSTSTIPGPS TEPSVVESKD1080
 1081 RKANAHFILK LLCDSVVLQP YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA1140
 1141 KAEISSSEKE EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG1200
 1201 LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA RLDLLYRLLT1260
 1261 ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE DRNRKTASPE DSDMPDHDLE1320
 1321 PPRFAQLALE RVLQDWNALK SMIMFGSQEN KDPLSASSRI GHLLPEEQVY LNQQSGTIRL1380
 1381 DCFTHCLIVK CTADILLLDT LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS1440
 1441 VEMASSKKKN NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA1500
 1501 STSIDAMQGS EELFSVEPLP PRPSSDQSSS SSQSQSSYII RNPQQRRISQ SQPVRGRDEE1560
 1561 QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG QHDEHDEDGS DMELDLLAAA1620
 1621 ETESDSESNH SNQDNASGRR SVVTAATAGS EAGASSVPAF FSEDDSQSND SSDSDSSSSQ1680
 1681 SDDIEQETFM LDEPLERTTN SSHANGAAQA PRSMQWAVRN TQHQRAASTA PSSTSTPAAS1740
 1741 SAGLIYIDPS NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG1800
 1801 LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSIMDSTE AQLRYGSALA1860
 1861 SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR ATLLSARQGM MSARGDFLNY1920
 1921 ALSLMRSHND EHSDVLPVLD VCSLKHVAYV FQALIYWIKA MNQQTTLDTP QLERKRTREL1980
 1981 LELGIDNEDS EHENDDDTNQ SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF2040
 2041 EVPLAEAIPL ADQPHLLQPN ARKEDLFGRP SQGLYSSSAS SGKCLMEVTV DRNCLEVLPT2100
 2101 KMSYAANLKN VMNMQNRQKK EGEEQPVLPE ETESSKPGPS AHDLAAQLKS SLLAEIGLTE2160
 2161 SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF MEDVGAEPGS ILTELGGFEV2220
 2221 KESKFRREME KLRNQQSRDL SLEVDRDRDL LIQQTMRQLN NHFGRRCATT PMAVHRVKVT2280
 2281 FKDEPGEGSG VARSFYTAIA QAFLSNEKLP NLECIQNANK GTHTSLMQRL RNRGERDRER2340
 2341 EREREMRRSS GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPEPL PAHRQALGER2400
 2401 LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII AHGRENGADS2460
 2461 ILDLGLVDSS EKVQQENRKR HGSSRSVVDM DLDDTDDGDD NAPLFYQPGK RGFYTPRPGK2520
 2521 NTEARLNCFR NIGRILGLCL LQNELCPITL NRHVIKVLLG RKVNWHDFAF FDPVMYESLR2580
 2581 QLILASQSSD ADAVFSAMDL AFAIDLCKEE GGGQVELIPN GVNIPVTPQN VYEYVRKYAE2640
 2641 HRMLVVAEQP LHAMRKGLLD VLPKNSLEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES2700
 2701 GENAEKLLQF KRWFWSIVEK MSMTERQDLV YFWTSSPSLP ASEEGFQPMP SITIRPPDDQ2760
 2761 HLPTANTCIS RLYVPLYSSK QILKQKLLLA IKTKNFGFV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	gi\|14317902, gi\|...	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: UBR5

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: