Protein Overview: TRIM21

General Information:
Name(s) found:	TRIM21 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|747927\|gb\|AAA79867.1\| RO52 gene product [NCBI NR] gi\|665918\|gb\|AAB87094.1\| 52 kda component of SS-A/Ro autoantigen [Homo sapiens] [NCBI NR] gi\|337485\|gb\|AAA36581.1\| 52-kD Ro/SSA ribonucleoprotein [NCBI NR] gi\|15208660\|ref\|NP_003132.2\| tripartite motif protein 21 [Homo sapiens] [NCBI NR] gi\|14790039\|gb\|AAH10861.1\| Tripartite motif-containing 21 [Homo sapiens] [NCBI NR] gi\|133250\|sp\|P19474.1\|RO52_HUMAN RecName: Full=52 kDa Ro protein; AltName: Full=Sjoegren syndrome type A antigen; Short=SS-A; AltName: Full=Ro(SS-A); AltName: Full=52 kDa ribonucleoprotein autoantigen Ro/SS-A; AltName: Full=Tripartite motif-containing pro [NCBI NR] gi\|119589251\|gb\|EAW68845.1\| tripartite motif-containing 21 [Homo sapiens] [NCBI NR] pir\|\|A37241 52K autoantigen Ro/SS-A - human [NCBI NR] tripartite motif-containing 21 [HGNC (HUGO)] E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens GN=TRIM21 PE=1 SV=1 [Swiss-Prot] 52kD Ro/SSA autoantigen [hmr_yeast5_DM3-1_pombe.fasta] 52kD Ro/SSA autoantigen; Sjogren syndrome antigen A1 (52kD, ribonucleoprotein autoantigen SS-A/Ro); Sicca syndrome antigen A; tripartite motif protein TRIM21 [HMR_022704.fasta] 52kD Ro/SSA autoantigen [Homo sapiens]gi\|14790039\|gb\|AAH10861.1\| 52kD Ro/SSA autoantigen [Homo sapiens]gi\|133250\|sp\|P19474\|RO52_HUMAN 52 kDa Ro protein (Sjogren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A)gi [nrdb_11152004_Chlamydomonas] 52 kDa Ro protein (Sjogren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif protein 21) (RING finger protein 81) [Yateslab_human_na_07-28-2006_reversed.fasta] (NM_003141) 52kD Ro/SSA autoantigen; Sjogren syndrome antigen A1; Sicca syndrome antigen A; tripartite motif protein TRIM21 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] 52kD Ro/SSA autoantigen [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] 52kD Ro/SSA autoantigen; Sjogren syndrome antigen A1 (52kD, ribonucleoprotein autoantigen SS-A/Ro); Sicca syndrome antigen A; tripartite motif protein TRIM21 [Homo sapiens] [HumanGallus06162005.fasta] 52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif-containing protein 21) (RING finger protein 81) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] tripartite motif protein 21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] tripartite motif-containing 21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tripartite motif-containing 21 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] 52 kda component of SS-A/Ro autoantigen [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] RO52 gene product [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] 52-kD Ro/SSA ribonucleoprotein [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=TRIM21 52 kDa Ro protein [human-ipi-250309-contam.fasta] IPI:IPI00018971.8\|SWISS-PROT:P19474\|TREMBL:Q5XPV5\|ENSEMBL:ENSP00000254436\|REFSEQ:NP_003132\|H-INV:HIT000035080 Tax_Id=9606 Gene_Symbol=TRIM21 52 kDa Ro protein [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] 52 kDa Ro protein [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] 52 kDa Ro protein OS=Homo sapiens GN=TRIM21 PE=1 SV=1 [UniProtHuman070710.fasta] P19474;Q96RF8; RecName: Full=52 kDa Ro protein; AltName: Full=Sjoegren syndrome type A antigen; AltName: Full=Ro(SS-A); AltName: Full=52 kDa ribonucleoprotein autoantigen Ro/SS-A; AltName: Full=Tripartite motif-containing protein 21; AltName: Full=RING finger protein 81; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens GN=TRIM21 [011711_HMR.fasta] GeneSymbol=TRIM21 Synonyms=RNF81\|RO52\|SSA\|SSA1 E3 ubiquitin-protein ligase TRIM21 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00018971.8\|SWISS-PROT:P19474-1\|ENSEMBL:ENSP00000254436\|REFSEQ:NP_003132\|H-INV:HIT000035080\|VEGA:OTTHUMP00000230775 Tax_Id=9606 Gene_Symbol=TRIM21 Isoform 1 of E3 ubiquitin-protein ligase TRIM21 [ipi.HUMAN.20110912.fasta] E3 ubiquitin-protein ligase TRIM21 GN=TRIM21 [Doctor+uniprot-HUMAN-120911.fasta] Tax_Id=9606 Gene_Symbol=TRIM21 Isoform 1 of E3 ubiquitin-protein ligase TRIM21 [human-ipi-270911-contam-BSA.fasta]
Organism:	Homo sapiens
Length:	475 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL  60
   61 KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 120
  121 RDHAMVPLEE AAQEYQEKLQ VALGELRRKQ ELAEKLEVEI AIKRADWKKT VETQKSRIHA 180
  181 EFVQQKNFLV EEEQRQLQEL EKDEREQLRI LGEKEAKLAQ QSQALQELIS ELDRRCHSSA 240
  241 LELLQEVIIV LERSESWNLK DLDITSPELR SVCHVPGLKK MLRTCAVHIT LDPDTANPWL 300
  301 ILSEDRRQVR LGDTQQSIPG NEERFDSYPM VLGAQHFHSG KHYWEVDVTG KEAWDLGVCR 360
  361 DSVRRKGHFL LSSKSGFWTI WLWNKQKYEA GTYPQTPLHL QVPPCQVGIF LDYEAGMVSF 420
  421 YNITDHGSLI YSFSECAFTG PLRPFFSPGF NDGGKNTAPL TLCPLNIGSQ GSTDY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	gi\|14317902, gi\|...	No Comments	Cheeseman, I.M., et al. (2004)
View Run	MIS12	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: TRIM21

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: