Protein Overview: CYT2

General Information:
Name(s) found:	CYT2 / YKL087C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322763\|ref\|NP_012836.1\| Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; Cyt2p [Saccharomyces cerevisiae] [NCBI NR] gi\|486129\|emb\|CAA81925.1\| CYT2 [Saccharomyces cerevisiae] [NCBI NR] gi\|3631\|emb\|CAA47407.1\| cytochrome c1 heme lyase [Saccharomyces cerevisiae] [NCBI NR] gi\|231973\|sp\|Q00873.1\|CYT2_YEAST RecName: Full=Cytochrome c1 heme lyase; Short=CC1HL [NCBI NR] pir\|\|S24365 holocytochrome-c synthase (EC 4.4.1.17) CYT2 - yeast (Saccharomyces cerevisiae) [NCBI NR] Cytochrome c1 heme lyase OS=Saccharomyces cerevisiae GN=CYT2 PE=1 SV=1 [Swiss-Prot] CYT2 Holocytochrome-c1 synthase [mips] Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 [SGD] CYT2, Chr XI from 276831-277505, reverse complement [yeast_orfs2] Chr XI from 276831-277505, reverse complement [yeastorf3.fasta] Chr XI from 276830-277504, reverse complement [yeastorf4.fasta] Chr XI from 277504-276830, reverse complement [yeastorf5.fasta] (Q00873) Cytochrome C1 heme lyase (EC 4.4.1.-) (CC1HL) [4932.FASTACCERV.txt] CYT2 SGDID:S0001570, Chr XI from 277508-276834, reverse complement, Verified ORF [yeastflysequest.fasta] Cyt2p [Saccharomyces cerevisiae]gi\|3631\|emb\|CAA47407.1\| cytochrome c1 heme lyase [Saccharomyces cerevisiae]gi\|486129\|emb\|CAA81925.1\| CYT2 [Saccharomyces cerevisiae]gi\|101272\|pir\|\|S24365 holocytochrome-c synthase (EC 4.4.1.17) CYT2 - yeast (Saccharomyc [nrdb_11152004_Chlamydomonas] CYT2 SGDID:S000001570, Chr XI from 277507-276833, reverse complement, Verified ORF, "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apoc [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; Cyt2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] cytochrome c1 heme lyase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CYT2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Cytochrome c1 heme lyase (CC1HL) [nr-271106-contam.fasta] CYT2 SGDID:S000001570, Chr XI from 277507-276833, reverse complement, Verified ORF, "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Cytochrome c1 heme lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYT2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CYT2 SGDID:S000001570, Chr XI from 277863-277189, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1" [yeast-030211-contam.fasta] CYT2 SGDID:S000001570, Chr XI from 277863-277189, Genome Release 64-2-1, reverse complement, Verified ORF, "Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1" [20141208_orf_trans.fasta] YKL087C SGDID:S000001570, Chr XI from 277863-277189, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] Cytochrome c1 heme lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYT2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Saccharomyces cerevisiae
Length:	224 amino acids
Gene Ontology:
Cellular Component:	mitochondrial intermembrane space [IDA] mitochondrion [IDA]
Biological Process:	cytochrome c-heme linkage [IMP][ISS]
Molecular Function:	holocytochrome-c synthase activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSSDQQGKC PVDEETKKLW LREHGNEAHP GATAPGNQLE CSANPQDNDK TPEYHTTVDL  60
   61 SQSREVSTIP RTNSDRNWIY PSEKQFYEAM MKKNWDPNSD DMKVVVPLHN SINERVWNYI 120
  121 KSWEDKQGGE ACGGIKLTNF KGDSKKLTPR AWFRSRILHL AKPFDRHDWQ IDRCGKTVDY 180
  181 VIDFYSTDLN DANSQQQPLI YLDVRPKLNS FEGFRLRFWK SLGF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		CYC3 CYT2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RRB1	CYT2	1	Unpublished Fields Lab Data
View Screen	SMC5	CYT2	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..224]	Pfam	148.236572	Cytochrome c/c1 heme lyase No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2