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Protein Overview: ATP12

General Information:
Name(s) found: ATP12 / YJL180C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 325 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: proton-transporting ATP synthase complex assembly [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein domain specific binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPSLRKGCF IVNSIRLKLP RFYSLNAQPL GTDNTIENNT PTETNRLSKT SQKFWEKVSL  60
   61 NRDVEKGKIA LQLDGRTIKT PLGNGIIVDN AKSLLAYLLK LEWSSLSSLS IKTHSLPLTS 120
  121 LVARCIDLQM TNEPGCDPQL VAKIGGNSDV IKNQLLRYLD TDTLLVFSPM NEFEGRLRNA 180
  181 QNELYIPIIK GMEEFLRNFS SESNIRLQIL DADIHGLRGN QQSDIVKNAA KKYMSSLSPW 240
  241 DLAILEKTVL TTKSFICGVL LLENKKDTAN LIPALKTDMD NIVRAATLET IFQVEKWGEV 300
  301 EDTHDVDKRD IRRKIHTAAI AAFKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ATP11 ATP12 DEF1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ATP12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] MSA 1.011978 View MSA. No confident structure predictions are available.
    2 View Details [135..213] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [214..325] MSA 1.011977 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.72024350544232 bayes_pls_golite062009
  • protein binding
    		•  1.2388395457113 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle