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Protein Overview: RRP46

General Information:
Name(s) found: RRP46 / YGR095C [SGD]
Description(s) found:
Found 14 descriptions.
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  • Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 256 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic exosome (RNase complex) [IDALink to PubMed article]
    nuclear exosome (RNase complex) [IDALink to PubMed article]
    nuclear outer membrane [TASLink to PubMed article]
    Biological Process: mRNA catabolic process [IPILink to PubMed article]
    Molecular Function: 3'-5'-exoribonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQLRCIKYL CIYGNNKEPN TKNRLDSAEK KKKMSVQAEI GILDHVDGSS EFVSQDTKVI  60
   61 CSVTGPIEPK ARQELPTQLA LEIIVRPAKG VATTREKVLE DKLRAVLTPL ITRHCYPRQL 120
  121 CQITCQILES GEDEAEFSLR ELSCCINAAF LALVDAGIAL NSMCASIPIA IIKDTSDIIV 180
  181 DPTAEQLKIS LSVHTLALEF VNGGKVVKNV LLLDSNGDFN EDQLFSLLEL GEQKCQELVT 240
  241 NIRRIIQDNI SPRLVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..34]
    [166..237]    		 PSI-BLAST 49.69897 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    2 View Details [35..165]
    [238..256]    		 PSI-BLAST 49.69897 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle