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Protein Overview: ATG15

General Information:
Name(s) found: ATG15 / YCR068W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 520 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IPILink to PubMed article][ISSLink to PubMed article]
    vacuolar lumen [IDALink to PubMed article]
    Biological Process: vacuolar protein processing [IDALink to PubMed article][IMPLink to PubMed article]
    autophagy [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    membrane disassembly [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: lipase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHKSPSRKR FASPLHLGCI LTLTVLCLIA YYFALPDYLS VGKSSSRGAM DQKSDGTFRL  60
   61 KSIYRHGVGA NHRLHQRLEV TPEVISAAGM LYQETTTQGQ DFEDQEPLWT TNAEYATTNP 120
  121 FDFEFELRRM PLLMKRMKER DPEFIESYIY GETYMTEEEE HAMWIDDDIV APNITDRGTV 180
  181 VSLALMSSNA YVRIPQTGDW RNVTEPWNET EPEDFGWDGD GIRGHVFYNE VENIVVLSIK 240
  241 GTSAQGLPGS GEDETTGNDK INDNLLFSCC CARVSYLWTT VCDCYVKSYI CDESCLEKEL 300
  301 RRKDRFYSAV VDIYKGVLKE YPDAAIWVTG HSLGGALASL LGRTFGLPAV AFESPGELLP 360
  361 SKRLHLPFPP GLPSYMEGIW HFGHNADPIF MGTCNGASSS CSLVGYAMET ACHTGRVCVY 420
  421 DVVNDKGWSV NMFNHRIHKV IDEVLLGYEQ AAKCVEPEPC VDCYNWKFIP SRDWESSSRL 480
  481 ITKTKSHAAP TTTTRTTATT TSSSTCVGRN WLGFCTKYEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] deduced N/A No confident structure predictions are available.
    2 View Details [221..371] PSI-BLAST 31.0 Triacylglycerol lipase
    3 View Details [372..520] MSA 1.028937 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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