Protein Overview: CG11727-PA

General Information:
Name(s) found:	CG11727-PA / FBpp0073392 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|74871763\|sp\|Q9VYY9.3\|Y1727_DROME RecName: Full=TBC1 domain family member CG11727 [NCBI NR] gi\|62484427\|ref\|NP_727526.2\| CG11727, isoform A [Drosophila melanogaster] [NCBI NR] gi\|61677886\|gb\|AAF48044.3\| CG11727, isoform A [Drosophila melanogaster] [NCBI NR] TBC1 domain family member CG11727 OS=Drosophila melanogaster GN=CG11727 PE=1 SV=3 [Swiss-Prot] Ecotropic viral integration site 5 ortholog OS=Drosophila melanogaster GN=Evi5 PE=1 SV=3 [Swiss-Prot] This gene is referred to in FlyBase by the symbol Dmel\CG11727 (CG11727, FBgn0030299). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11326945..11348335. It has the cytological map location 10B11-10B14. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: Rab GTPase activator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of Rab GTPase activity. 5 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] type=protein; loc=X:complement(11327313..11327450,11329416..11329514,11329582..11329699,11329762..11330429,11330808..11330825,11331056..11331170,11331237..11332272,11332696..11332927); ID=FBpp0073392; name=CG11727-PA; parent=FBgn0030299,FBtr0073547; dbxre [fly-100309-contam.fasta] CG11727-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:complement(11327313..11327450,11329416..11329514,11329582..11329699,11329762..11330429,11330808..11330825,11331056..11331170,11331237..11332272,11332696..11332927); ID=FBpp0073392; name=CG11727-PA; parent=FBgn0030299,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:complement(11327313..11327450,11329416..11329514,11329582..11329699,11329762..11330429,11330808..11330825,11331056..11331170,11331237..11332272,11332696..11332927); ID=FBpp0073392; name=CG11727-PA; parent=FBgn0030299,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:complement(11327313..11327450,11329416..11329514,11329582..11329699,11329762..11330429,11330808..11330825,11331056..11331170,11331237..11332272,11332696..11332927); ID=FBpp0073392; name=CG11727-PA; parent=FBgn0262740,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044,FlyMine:FBpp0073392,modMine:FBpp0073392; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:complement(join(11438663..11438894,11437204..11438239,11437023..11437137,11436775..11436792,11435729..11436396,11435549..11435666,11435383..11435481,11433280..11433417)); ID=FBpp0073392; name=Evi5-PA; parent=FBgn0262740,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044,FlyMine:FBpp0073392,modMine:FBpp0073392; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:complement(join(11438663..11438894,11437204..11438239,11437023..11437137,11436775..11436792,11435729..11436396,11435549..11435666,11435383..11435481,11433280..11433417)); ID=FBpp0073392; name=Evi5-PA; parent=FBgn0262740,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044,FlyMine:FBpp0073392,modMine:FBpp0073392; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0073392 type=protein; loc=X:complement(join(11438663..11438894,11437204..11438239,11437023..11437137,11436775..11436792,11435729..11436396,11435549..11435666,11435383..11435481,11433280..11433417)); ID=FBpp0073392; name=Evi5-PA; parent=FBgn0262740,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044,FlyMine:FBpp0073392,modMine:FBpp0073392; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:complement(join(11438663..11438894,11437204..11438239,11437023..11437137,11436775..11436792,11435729..11436396,11435549..11435666,11435383..11435481,11433280..11433417)); ID=FBpp0073392; name=Evi5-PA; parent=FBgn0262740,FBtr0073547; dbxref=GB_protein:AAF48044.2,FlyBase_Annotation_IDs:CG11727-PA,FlyBase:FBpp0073392,GB_protein:AAF48044.3,REFSEQ:NP_727526,GB_protein:AAF48044,UniProt/Swiss-Prot:Q9VYY9,FlyMine:FBpp0073392,modMine:FBpp0073392; MD5=2f762cde6eee8b1c44bb16bdddeb2b50; length=807; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	807 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of Rab GTPase activity [IEA]
Molecular Function:	Rab GTPase activator activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLTTTTTAS SAESQAKMDV KGGALPGEEN LPTSEMDLLA KLEAANKLIE SDAKSLNSLH  60
   61 STHSRKNSDT SQISLTSSGN SVAEEDIWTT WATILNDWEG ALKRKNPCVS ELVRRGIPHH 120
  121 FRAIVWQQLS GASDGDKKQY AEYIKATSAC EKVIRRDIAR TYPEVEFFKE KDGPGQEALF 180
  181 NVIKAYSLHD REVGYCQGSG FIVGLLLMQM PEEEAFAVLV QIMQQHRMRH MFKPSMSELG 240
  241 LCMYQLENLV QEQIPDMHIH FQQQGFQTTM YASSWFLTLY TTTLNVNLSC RIMDVFLSEG 300
  301 MEFIFKVALA LLLTGKDTLL CLDMEAMLKF FQKELPGRVE ADVEGFFNLA YSIKLNTKRM 360
  361 KKMEKEYQDL KKKEQEEMAE LRRLRRENCL LKQRNELLEA ESAELADRLV RGQVSRAEEE 420
  421 ETSYAIQTEL MQLRRSYLEV SHQLENANEE VRGLSLRLQE NNVSIDSNNS RQSSIDELCM 480
  481 KEEALKQRDE MVSCLLEELV KVRQGLAESE DQIRNLKAKV EELEEDKKTL RETTPDNSVA 540
  541 HLQDELIASK LREAEASLSL KDLKQRVQEL SSQWQRQLAE NQRSESERTT NAVDSTPKKL 600
  601 LTNFFDSSKS SEHTQKLEEE LMTTRIREME TLTELKELRL KVMELETQVQ VSTNQLRRQD 660
  661 EEHKKLKEEL EMAVTREKDM SNKAREQQHR YSDLESRMKD ELMNVKIKFT EQSQTVAELK 720
  721 QEISRLETKN SEMLAEGELR ANLDDSDKVR DLQDRLADMK AELTALKSRG KFPGAKLRSS 780
  781 SIQSIESTEI DFNDLNMVRR GSTELST

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..66]	deduced	N/A	No confident structure predictions are available.
2	View Details	[67..355]	PSI-BLAST	50.30103	No description for 2qq8A was found.
3	View Details	[356..443]	FFAS03	1.16	No description for 2fxmA was found.
4	View Details	[444..807]	PSI-BLAST	20.69897	Heavy meromyosin subfragment

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.73

Protein Overview: CG11727-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: