Protein Overview: BIG1_RAT

General Information:
Name(s) found:	BIG1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|62648539\|ref\|XP_232614.3\| PREDICTED: similar to brefeldin A-inhibited guanine nucleotide-exchange protein 1 [Rattus norvegicus] [NCBI NR] gi\|149060934\|gb\|EDM11544.1\| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI NR] Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Rattus norvegicus GN=Arfgef1 PE=1 SV=1 [Swiss-Prot] ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited) (Predicted), isoform CRA_a OS=Rattus norvegicus GN=Arfgef1 [011711_HMR.fasta] ADP-ribosylation factor guanine nucleotide-exchange factor 1(Brefeldin A-inhibited) (Predicted), isoform CRA_a OS=Rattus norvegicus GN=Arfgef1 PE=4 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	1846 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of ARF protein signal transduction [IEA]
Molecular Function:	protein binding [UNKNOWN] [NOT]ARF GTPase activator activity [UNKNOWN] ARF guanyl-nucleotide exchange factor activity [IEA] guanyl-nucleotide exchange factor activity [UNKNOWN] myosin binding [UNKNOWN] binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKVETEK QSPPHGEAKA  60
   61 GSGTLPPVKS KTNFIEADKY FLPFELACQS KCPRIVSTSL DCLQKLIAYG HLTGSAPDST 120
  121 TPGKKLIDRI IETICGCFQG PQTDEGVQLQ IIKALLTAVT SQHIEIHEGT VLQAVRTCYN 180
  181 IYLASKNLIN QTTAKATLTQ MLNVIFARME NQALQEAKQM ERERHRQQHH LLQSPVSHHE 240
  241 PESPHLRYLP PQTVDHIAQE QEGDLDPQTH DVDKSLQDDI EPENGSDISS AENEQTEADQ 300
  301 ATAAETLSKD DVLCDGECEE KPQDIVQSIV EEMVDIIVGD MGEGTAVSAS ADGNAGAVED 360
  361 GSDSENVQAN GIPGTPISAA YTPSLPDDRL SVSSNDTQES GNSSGPSPGA KFSHILQKDA 420
  421 FLVFRSLCKL SMKPLSDGPP DPKSHELRSK ILSLQLLLSI LQNAGPVFRT NEMFINAIKQ 480
  481 YLCVALSKNG VSSVPEVFEL SLSIFLTLLS NFKTHLKMQI EVFFKEIFLY ILETSTSSFD 540
  541 HKWMVIQTLT RICADAQSVV DIYVNYDCDL NAANIFERLV NDLSKIAQGR GSQELGMSNV 600
  601 QELSLRKKGL ECLVSILKCM VEWSKDQYVN PNSQTTLGQE KPSEQEISEI KHPETINRYG 660
  661 SLNSLESTSS SGIGSYSTQM SGTDNPEQFE VLKQQKEIIE QGIDLFNKKP KRGIQYLQEQ 720
  721 GMLGTTPEDI AQFLHQEERL DSTQAGEFLG DNDKFNKEVM YAYVDQHDFS GKDFVSALRL 780
  781 FLEGFRLPGE AQKIDRLMEK FAARYLECNQ GQTLFASADT AYVLAYSIIM LTTDLHSPQV 840
  841 KNKMTKEQYI KMNRGINDSK DLPEEYLSAI YNEIAGKKIS MKETKELTIP TKSTKQNVAS 900
  901 EKQRRLLYNL EMEQMAKTAK ALMEAVSHVQ APFTSATHLE HVRPMFKLAW TPFLAAFSVG 960
  961 LQDCDDTDVA SLCLEGIRCA IRIACIFSIQ LERDAYVQAL ARFTLLTVSS GITEMKQKNI1020
 1021 DTIKTLITVA HTDGNYLGNS WHEILKCISQ LELAQLIGTG VKPRYISGTV RGREGSLTGT1080
 1081 KDQAPDEFVG LGLVGGNVDW KQIASIQESI GETSSQSVVV AVDRIFTGST RLDGNAIVDF1140
 1141 VRWLCAVSMD ELLSTTHPRM FSLQKIVEIS YYNMGRIRLQ WSRIWEVIGD HFNKVGCNPN1200
 1201 EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKRNRSPTIR DMVVRCIAQM1260
 1261 VNSQAANIRS GWKNIFSVFH LAASDQDESI VELAFQTSGH IVTLVFEKHF PATIDSFQDA1320
 1321 VKCLSEFACN AAFPDTSMEA IRLIRHCAKY VSDRPQAFKE YTSDDMNVAP EDRVWVRGWF1380
 1381 PILFELSCVI NRCKLDVRTR GLTVMFEIMK TYGHTYEKHW WQDLFRIVFR IFDNMKLPEQ1440
 1441 QTEKAEWMTT TCNHALYAIC DVFTQYLEVL SDVLLDDIFA QLYWCVQQDN EQLARSGTNC1500
 1501 LENVVILNGE KFTLEIWDKT CNCTLDIFKT TIPHALLTWR PTSGEAAPPS PSAMSEKQLD1560
 1561 AISQKSVDIH DSAQPRSSDN RQQAPLVSVS PASEEVSKGR PTAKFPEQKL FAALLIKCVV1620
 1621 QLELIQTIDN IVFFPATSKK EDAENLAAAQ RDAVDFDVRV DTQDQGMYRF LTSQQLFKLL1680
 1681 DCLLESHRFA KAFNSNNEQR TALWKAGFKG KSKPNLLKQE TSSLACGLRI LFRMYTDESR1740
 1741 VSAWEEVQQR LLNVCSEALS YFLTLTSESH REAWTNLLLL FLTKVLKISD NRFKAHASFY1800
 1801 YPLLCEIMQF DLIPELRAVL RRFFLRIGIV FQISQPPEQE LGINKQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: BIG1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: