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Protein Overview: RhoGAP15B-PB

General Information:
Name(s) found: RhoGAP15B-PB / FBpp0110289 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • The gene RhoGAP15B is referred to in FlyBase by the symbol Dmel\RhoGAP15B (CG4937, FBgn0030808). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16842895..16850031. It has the cytological map location 15C4. Based on sequence similarity, it is predicted to have molecular function</span>: small GTPase regulator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: signal transduction. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1510 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: signal transduction [IEA]
    Molecular Function: small GTPase regulator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQARPVPAP RRLYPELRPA NYENIEIRRP NSPSNNINHN NIKKLNINAE NLHGNCAEKK  60
   61 LPSSGQNKLI LQENNSDSQQ PIYGPDANEN VQEPVYATPR PAPRQRLPPA GEPEDSYPDP 120
  121 DDEVPLRILR AAPQIPPKPL NILLDQRSSI CSEVSTTSVQ TPGKADEDRE GSRYASNASL 180
  181 DCSESSHSGK FKSQSPGNLL RSLGTTSKLL GEAIGERITF KAKGAKKRLD RNFKSSTEAI 240
  241 SNIGADAGRS LKHASKRFGS NFSLGRNKDK ADIGIGGRPG GSGEMDLDRR QTMPSTEVFN 300
  301 TIQFSSPLNR NGGLPDLREN DAKLQKEDYL RPDPDQEDDG CYEVPKTQGK PPSYDEALRS 360
  361 RPSPSDSPMS RNLAQEAAQL VQLRNQRQLS SSSSNGDESP RLPMPAFPPP RLSQQPEQFR 420
  421 MDALQPPVRQ KRRKNYEHIE LRRPPVDSAQ LEELNRAAAA AEREESLLIS AKNAEAETKT 480
  481 PKPERSDSWE FYGEDENEEE DRDEEQEGSS SPEPLYANQE ATYGKLFEMA TAGSSRSNVL 540
  541 TPNQVAEQQQ LACITEDSEL DACEGAVGGV PLPQAVIEEF DPLSSKCSTL ARSNKSNELL 600
  601 LLEHLLEEDT YGTVKAEQDD VSMCTSEEEP TTSAATSPKP QQPQIVHQNA RLLSDSMENM 660
  661 LDSDQERAKP YLSRMPESAN KASGPVDLAS ASRNRTNWFV PDKASCSDVT PNTSKTTPPI 720
  721 EGDSPPTYLE AIGGSKDAAG NQENRSTIGS RFRQTINAIS NVKLKMDAMK RKASFRGANQ 780
  781 RQSDVRVALQ MVPRPSLSPL LIRYEGPLVR FPSGVVEDIL KEMQNRKAIL RERQFQTFLD 840
  841 QEMKTPREMI PLDTITTLQC VSNSRVTDTA THFYCFEITT SQPKNGNGAG DAMSSNPNLL 900
  901 MTSSSSGNVK QQRVSHLYGV GKESERGVWM QKILESLTNS LPVKYTCHYY RAGWCYLKNS 960
  961 ITSEWSGTWL VLRKSQRRLI FVSEANGNVE KMDLRKARCI VLKESDESID NLHVESGPML1020
 1021 MIDCPPYAVY MIMSSARETK IWRHIIREVA HNNGFSLGDQ QLTRYDVPVI VDKCINFVYI1080
 1081 HGSMSEGIYR KSGSENSMHK LMSAFRADAF NVEITRNEYN EHDVANVLKR FMRDLPERLL1140
 1141 GKLTDSFVFV TELAVASEKI PIYRELLARL SAIERETLRR IVGHLVFISS QQAKNKMSVQ1200
 1201 NLTMIWGPTL LAKKSDELIY SQKEADVLSD LVVLYKNLFP CSADEIKREQ AMLACLQKYY1260
 1261 AAAETLKDAV KQSGDIKIWI SLNPNPENKT EEKTQVNATI SPTKTAYELC REYSAKMQLP1320
 1321 THQLTLYEVI LNDSLERPLH HDTKVFDVIL NWSYWPEEDR KHNYLVVRPV EMLREIQRAV1380
 1381 KNLATVTPGK ELRFADSRTK TFKTLQCELR DGKIVVSKKD KNDKTTIVRE IFLQSSTAYL1440
 1441 GCERKRDFPW SWAITFVERT QAQIMRSRDA PFIGHVLAGS EWGDRTIWYS SIWYCLYRDN1500
 1501 ILPPAEIIIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..318] deduced N/A No confident structure predictions are available.
    2 View Details [319..533] MSA 1.179996 View MSA. No confident structure predictions are available.
    3 View Details [534..790] deduced N/A No confident structure predictions are available.
    4 View Details [791..871] PSI-BLAST 6.30103 Triglycine variant of the Grp1 Pleckstrin Homology Domain unliganded
    5 View Details [872..1241] PSI-BLAST 45.221849 Crystal Structure of the Human Beta2-Chimaerin
    6 View Details [1242..1510] PSI-BLAST 21.39794 No description for 2psoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • enzyme activator activity
    		•  0.53004209819211 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.528693496432149 bayes_pls_golite062009
  • binding
    		•  0.0980674097362609 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.0454578418356197 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle