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Protein Overview: TOP2_DICDI

General Information:
Name(s) found: TOP2_DICDI [Swiss-Prot]
Description(s) found:
Found 4 descriptions.
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  • Probable DNA topoisomerase 2 OS=Dictyostelium discoideum GN=top2 PE=3 SV=1 [Swiss-Prot]
    • Organism: Dictyostelium discoideum
    Length: 1521 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    chromosome [ISS]
    Biological Process: DNA topological change [ISS]
    Molecular Function: ATPase activity [ISS]
    DNA binding [ISS]
    ATP binding [ISS]
    DNA topoisomerase (ATP-hydrolyzing) activity [ISS]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSENDYSD ESSGSEYESP VKKGKSAPKK PAAAGSKKKA SATRKPAAKK ATTTTTSTTK  60
   61 KSTTSKKSES DNDDFSGDDK SSSSDNENVF KNIASSAKKG KSIEEIYQKK ELLDQILLRP 120
  121 DTYIGSTERQ EEELWVWEDK RMVHRKVSFV PGIYKIFDEI LVNAADNKQR EGNMKFIKVV 180
  181 IDREKGFISV TNDGAGIPIQ VHSEHKIYIP ELIFGNLLTS SHYDDSEKRL TGGRNGFGAK 240
  241 LANIFSTKFI VECADSKSKK LYKQTFTNNM RSKEDPKITS YQNKTDYTKI TFYPELDRFG 300
  301 MVEFDDDLVA LLSKRVYDIA GCNPTLKVSL NDEELGIRSF EKYINLYFPD EENAPKVYYE 360
  361 KVSDRWELAV TLSKESQFNQ VSFVNSICTV KGGTHVTHAL SNIVTAIQEQ VNKKNKGSAD 420
  421 IKPAFIKNHL SVFVNCLIEN PHFDSQTKET LTSKISSFGS RCEPSEKFIK RVLDSKSGIV 480
  481 ASILEFAQFK DQSALKRSTS SGGKKGKVSI PKLDDANLAG GTKSEDCTLI LTEGDSAKSL 540
  541 ATAGISVVGK DHYGAFPLKG KLLNVRDQST KVINNDEINN IVTILGLKYG KVYETLSDLR 600
  601 YGHLMIMTDQ DHDGSHIKGL IINMVHHFWP TLLRMPGFLV EFITPIVKVF KNNQKPISFY 660
  661 TMPEFLKWRE TNDKGWDVKY YKGLGTSTPG EGKEYFSDLE RHKIDFEWDE GANDNIELAF 720
  721 SKSRADDRKK WMAEHIEGTF LEQFGVKKLT YSDFINKELV LFSIADCERS IPNIVDGLKT 780
  781 SHRKTLYSCF KRNLKKEIKV AQLIGYVSEH SAYHHGEASL YSTIVGMAQE FVGSNNINLL 840
  841 NPAGSYGTRI AGGKDCSSAR YIHTRLNDIA RAVYHADDDP ILSCVVDDGK KVQPKFYIPV 900
  901 IPMILVNGCV GIGTGWSSTI PNYNPRDLIQ NMRLAIDGKP LKPIKPWYRG FLGSIEANQG 960
  961 SKVQGGQYLS KGIWKKLSDN RFEITELPIG FWTQDYRELL DELETPGTRK KKKEEKEKKA1020
 1021 ASRKGTKAKP TTTKRSKRVD DDDDNEKVTE ATVKSYTNYS SESTIHFIID TIQPVDEINI1080
 1081 EKVFKLVSTI NETNMVVFDE EGRIQRFATT TALQEHFFPL RIKHYQMRKD FLSERLSEEY1140
 1141 SRLSNKARFI LAVVNKELVI SNVKKVDLIN KLKEMKFDRI INKNSNKSAR DKIKKKKNAF1200
 1201 DEEDAAISSD EEKDGAQEEQ DDDTKGYDYL LSLPLWSLTL ERVKKLIEER DSKKKEWDIL1260
 1261 LSTPIQEIYK RDLDALEKAL DDQDAYDESL KNQTESLKKR TKTKALPRAK KISAKVVKDT1320
 1321 KEAPLTKLVK PTVKIPTTTD SNVSGSKRKK SDDTTSTSTS TTTSSNTKPI ESFFAKEDKK1380
 1381 PTPAVKKSTL VSLDSDSDFD DDVVVSSKPK APPKKTSKVI ELSDESDQES DQESDQGSDP1440
 1441 ESPPKRSKAP PKKPTTIATK KATTSKSKVI DDKSSDDEVI KAPTNRPTRS RVPPPKSLSF1500
 1501 LDSDSDDDDL YDNEESSSDS D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle