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Protein Overview: LEU1_SHEON

General Information:
Name(s) found: LEU1_SHEON [Swiss-Prot]
Description(s) found:
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  • gi|24375720|ref|NP_719763.1| 2-isopropylmalate synthase [Shewanella oneidensis MR-1] [NCBI NR]
  • gi|24350656|gb|AAN57207.1|AE015856_7 2-isopropylmalate synthase [Shewanella oneidensis MR-1] [NCBI NR]
  • 2-isopropylmalate synthase OS=Shewanella oneidensis (strain MR-1) GN=leuA PE=3 SV=1 [Swiss-Prot]
  • 2-isopropylmalate synthase [Shewanella oneidensis MR-1]gi|24350656|gb|AAN57207.1| 2-isopropylmalate synthase [Shewanella oneidensis MR-1]gi|39931563|sp|Q8E9N2|LEU1_SHEON 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase) [nrdb_11152004_Chlamydomonas]
  • 2-isopropylmalate synthase [Shewanella oneidensis MR-1] [nr-271106-contam.fasta]
    • Organism: Shewanella oneidensis MR-1
    Length: 522 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: leucine biosynthetic process [ISSLink to PubMed article]
    Molecular Function: 2-isopropylmalate synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNRVIIFDT TLRDGEQALA ASLSVKEKLQ IAMALERLGV DVMEVGFPVS SPGDFESVQT  60
   61 IARTIKNSRV CALSRALEKD IDAAAQALSV AEQFRIHTFI STSTIHVESK LKRSFEQVLE 120
  121 MAVGAVKYAR RFTDDVEFSC EDAGRTPIDN LCRMVEAAIH AGARTINIPD TVGYTVPSEF 180
  181 GSIIQTLFNR VPNIDQAIIS VHCHDDLGLS VANSITAVQH GARQIECTMN GIGERAGNCS 240
  241 LEEIAMILAT RKNLLGFETG INAKEIHRTS NLVSQLCNMP IQSNKAIVGA NAFTHSSGIH 300
  301 QDGMLKAQNT YEIMTPESIG LNRNNLNMTS RSGRHVIKHR MEEMGYSSQD YNLDALYEQF 360
  361 LHLADKKGQV FDYDLEALAF IEAQAAEDNF YQLRQLVVQS DSTEGVATAT VRIEVGGEIK 420
  421 TEAATGNGPV DAAYNAIARA TDRRIDIISY KLGAKGVGQD ALGQVDITAV YHEQNFHGVG 480
  481 LATDVVEASA RALVHVMNLT CRADKVADYK QNMHKNRELG GV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..522] PSI-BLAST 109.0 Crystal Structure of LeuA from Mycobacterium tuberculosis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-isopropylmalate synthase activity
    		•  3.07962096729216 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.96685031644778 bayes_pls_golite062009
  • catalytic activity
    		•  2.67031204377352 bayes_pls_golite062009
  • porphobilinogen synthase activity
    		•  1.24455949903754 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  1.14592921123611 bayes_pls_golite062009
  • binding
    		•  1.1388634428163 bayes_pls_golite062009
  • lyase activity
    		•  0.740424046054758 bayes_pls_golite062009
  • transaldolase activity
    		•  0.468395717570545 bayes_pls_golite062009
  • transferase activity
    		•  0.464721888799972 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.421097563118217 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  0.13873587393116 bayes_pls_golite062009
  • fructose-bisphosphate aldolase activity
    		•  0.0818126250353252 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle