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Protein Overview: PUR9_SHEON

General Information:
Name(s) found: PUR9_SHEON [Swiss-Prot]
Description(s) found:
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  • gi|24372037|ref|NP_716079.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Shewanella oneidensis MR-1] [NCBI NR]
  • gi|24345909|gb|AAN53524.1|AE015493_2 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Shewanella oneidensis MR-1] [NCBI NR]
  • Bifunctional purine biosynthesis protein PurH OS=Shewanella oneidensis (strain MR-1) GN=purH PE=3 SV=1 [Swiss-Prot]
  • phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Shewanella oneidensis MR-1]gi|24345909|gb|AAN53524.1| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Shewanella oneidensis MR-1]gi|32171650|sp|Q [nrdb_11152004_Chlamydomonas]
  • phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Shewanella oneidensis MR-1] [nr-271106-contam.fasta]
  • bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Shewanella oneidensis MR-1] [nr-271106-contam.fasta]
    • Organism: Shewanella oneidensis MR-1
    Length: 543 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: purine ribonucleotide biosynthetic process [ISSLink to PubMed article]
    Molecular Function: phosphoribosylaminoimidazolecarboxamide formyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVANHARPI RRALLSVSDK TGILEFAKAL HAQGVELLST GGTARLLADN GVPVIEVSDY  60
   61 TGHPEIMDGR VKTLHPKVHG GILARRGLDE NVMAANNINA IDLVAVNLYP FADTVAKAGC 120
  121 TLEDAIENID IGGPTMVRAA AKNHKDVTIV VNAADYNRVL AEMAVNNGST THATRFDLAI 180
  181 AAFEHTAGYD GMIANYFGTM VPMHRVPAHS TDECFQDSLS VEGSKFPRTF NTQLVKKQDL 240
  241 RYGENSHQAA AFYVDTKIDE ASVATAVQLQ GKALSYNNIA DTDAALECVK EFSEPACVIV 300
  301 KHANPCGVAL GKDLLDAYNR AYQTDPTSAF GGIIAFNGEL DAATASAIVE RQFVEVIIAP 360
  361 VVSQGARDVV AKKTNVRLLE CGQWNTKTQT LDYKRVNGGL LVQDRDQGMV GLDDIKVVTK 420
  421 RQPTESELKD LMFCWKVAKF VKSNAIVYAK DGMTIGVGAG QMSRVYSAKI AGIKAADEGL 480
  481 EVVNSVMASD AFFPFRDGID AAAAAGISCI IQPGGSMRDA EIIAAADEHG MAMVMTGMRH 540
  541 FRH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..543] PSI-BLAST 165.0 Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP cyclohydrolase activity
    		•  2.44338227123463 bayes_pls_golite062009
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    		•  2.17104645465987 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.1190774640451 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.79965948308471 bayes_pls_golite062009
  • catalytic activity
    		•  1.70756445127105 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  1.51378035087272 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  1.19388272840449 bayes_pls_golite062009
  • deaminase activity
    		•  1.16510523659661 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.03324558866637 bayes_pls_golite062009
  • cytidine deaminase activity
    		•  0.870445440530128 bayes_pls_golite062009
  • binding
    		•  0.778641298104072 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.738911503392967 bayes_pls_golite062009
  • hydrolase activity
    		•  0.339145951258927 bayes_pls_golite062009
  • protein binding
    		•  0.095488575269861 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle