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Protein Overview: TWF1_YEAST

General Information:
Name(s) found: TWF1_YEAST [Swiss-Prot]
Description(s) found:
  • Twinfilin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TWF1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 332 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTQSGIVAE QALLHSLNEN LSADGIVIII AKISPDSTSV HQTQVARSFE ELVQLASQER  60
   61 EPLYIFYKPE GLDKYFFVSF IPDGSPVRSR MLYASTKNTL ARQVGSNSLS TEQPLITDAQ 120
  121 DLVDLKNFDS ARPAGQNKPL THDEEMQIEI NKQQALLRKN TSVKLVSQDS ASPLSLTFRV 180
  181 NSEKPINEIL DSEGKNLIIF QIDPSNETIQ IVQSDTCPSV DELYIDLPGP SYTIFRQGDS 240
  241 SFFIYSCPSG SKVKDRMIYA SNKNGFINYL KNDQKIAFSK VVEIGDFVEL DKSLLMATNK 300
  301 EDSLDHGSNP DLPNKSNLKF NKPKGPLRKR RT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] PSI-BLAST 44.39794 Cofilin (actin depolymerizing factor, ADF)
    2 View Details [167..332] ORFEUS 14.09 Cofilin (actin depolymerizing factor, ADF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.52071741004022 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.04859625643932 bayes_pls_golite062009
  • actin filament binding
    		•  5.45532510538573 bayes_pls_golite062009
  • binding
    		•  2.41877859618486 bayes_pls_golite062009
  • protein kinase activity
    		•  2.22634235673758 bayes_pls_golite062009
  • protein binding
    		•  1.87981807141519 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.87091423399482 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.67227267699496 bayes_pls_golite062009
  • kinase activity
    		•  1.55883505515498 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.3406661967545 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.30213296029859 bayes_pls_golite062009
  • transferase activity
    		•  0.591259446255369 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.482954032096802 bayes_pls_golite062009
  • structural molecule activity
    		•  0.391701411061931 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.293715974535634 bayes_pls_golite062009
  • signal transducer activity
    		•  0.293715974535634 bayes_pls_golite062009
  • actin monomer binding
    		•  0.224304003054399 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle