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Protein Overview: HMDH2_YEAST

General Information:
Name(s) found: HMDH2_YEAST [Swiss-Prot]
Description(s) found:
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HMG2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1045 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPLKTIVH LVKPFACTAR FSARYPIHVI VVAVLLSAAA YLSVTQSYLN EWKLDSNQYS  60
   61 TYLSIKPDEL FEKCTHYYRS PVSDTWKLLS SKEAADIYTP FHYYLSTISF QSKDNSTTLP 120
  121 SLDDVIYSVD HTRYLLSEEP KIPTELVSEN GTKWRLRNNS NFILDLHNIY RNMVKQFSNK 180
  181 TSEFDQFDLF IILAAYLTLF YTLCCLFNDM RKIGSKFWLS FSALSNSACA LYLSLYTTHS 240
  241 LLKKPASLLS LVIGLPFIVV IIGFKHKVRL AAFSLQKFHR ISIDKKITVS NIIYEAMFQE 300
  301 GAYLIRDYLF YISSFIGCAI YARHLPGLVN FCILSTFMLV FDLLLSATFY SAILSMKLEI 360
  361 NIIHRSTVIR QTLEEDGVVP TTADIIYKDE TASEPHFLRS NVAIILGKAS VIGLLLLINL 420
  421 YVFTDKLNAT ILNTVYFDST IYSLPNFINY KDIGNLSNQV IISVLPKQYY TPLKKYHQIE 480
  481 DSVLLIIDSV SNAIRDQFIS KLLFFAFAVS ISINVYLLNA AKIHTGYMNF QPQSNKIDDL 540
  541 VVQQKSATIE FSETRSMPAS SGLETPVTAK DIIISEEIQN NECVYALSSQ DEPIRPLSNL 600
  601 VELMEKEQLK NMNNTEVSNL VVNGKLPLYS LEKKLEDTTR AVLVRRKALS TLAESPILVS 660
  661 EKLPFRNYDY DRVFGACCEN VIGYMPIPVG VIGPLIIDGT SYHIPMATTE GCLVASAMRG 720
  721 CKAINAGGGA TTVLTKDGMT RGPVVRFPTL IRSGACKIWL DSEEGQNSIK KAFNSTSRFA 780
  781 RLQHIQTCLA GDLLFMRFRT TTGDAMGMNM ISKGVEYSLK QMVEEYGWED MEVVSVSGNY 840
  841 CTDKKPAAIN WIEGRGKSVV AEATIPGDVV KSVLKSDVSA LVELNISKNL VGSAMAGSVG 900
  901 GFNAHAANLV TALFLALGQD PAQNVESSNC ITLMKEVDGD LRISVSMPSI EVGTIGGGTV 960
  961 LEPQGAMLDL LGVRGPHPTE PGANARQLAR IIACAVLAGE LSLCSALAAG HLVQSHMTHN1020
 1021 RKTNKANELP QPSNKGPPCK TSALL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] deduced N/A No confident structure predictions are available.
    2 View Details [67..533] MSA 52.362986 View MSA. No confident structure predictions are available.
    3 View Details [534..585] deduced N/A No confident structure predictions are available.
    4 View Details [586..685] PSI-BLAST 1590.0 NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase
    5 View Details [686..739]
    [842..1045]    		 PSI-BLAST 1590.0 NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase
    6 View Details [740..841] PSI-BLAST 1590.0 NAD-binding domain of HMG-CoA reductase; Substrate-binding domain of HMG-CoA reductase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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