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Protein Overview: EG13603

General Information:
Name(s) found: prpD / EG13603 [EcoGene]
Description(s) found:
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  • 2-methylcitrate dehydratase / 2-Methylcitrate dehydratase, 2-methylisocitrate hydratase; propionate catabolism via 2-methlycitrate cycle; active on citrate and isocitrate; responsible for residual apparent aconitase activity in acnAB double mutant; monomeric iron-sulfur protein [EcoGene]
  • 2-methylcitrate dehydratase [Escherichia coli K12] [nr-271106-contam.fasta]
  • similar to yqiP of B. subtilis [Escherichia coli] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • 2-methylcitrate dehydratase [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 483 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: propionate catabolic process, 2-methylcitrate cycle [IEA]
    carbohydrate catabolic process [IDALink to PubMed article]
    propionate catabolic process [IEA]
    propionate metabolic process, methylcitrate cycle [IDALink to PubMed article]
    Molecular Function: metal ion binding [IEA]
    iron ion binding [IEA]
    2-methylcitrate dehydratase activity [IDALink to PubMed article][IEA]
    iron-sulfur cluster binding [IEA]
    2 iron, 2 sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAQINNIRP EFDREIVDIV DYVMNYEISS KVAYDTAHYC LLDTLGCGLE ALEYPACKKL  60
   61 LGPIVPGTVV PNGVRVPGTQ FQLDPVQAAF NIGAMIRWLD FNDTWLAAEW GHPSDNLGGI 120
  121 LATADWLSRN AVASGKAPLT MKQVLTAMIK AHEIQGCIAL ENSFNRVGLD HVLLVKVAST 180
  181 AVVAEMLGLT REEILNAVSL AWVDGQSLRT YRHAPNTGTR KSWAAGDATS RAVRLALMAK 240
  241 TGEMGYPSAL TAPVWGFYDV SFKGESFRFQ RPYGSYVMEN VLFKISFPAE FHSQTAVEAA 300
  301 MTLYEQMQAA GKTAADIEKV TIRTHEACIR IIDKKGPLNN PADRDHCIQY MVAIPLLFGR 360
  361 LTAADYEDNV AQDKRIDALR EKINCFEDPA FTADYHDPEK RAIANAITLE FTDGTRFEEV 420
  421 VVEYPIGHAR RRQDGIPKLV DKFKINLARQ FPTRQQQRIL EVSLDRARLE QMPVNEYLDL 480
  481 YVI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..483] PSI-BLAST 164.0 Crystal Structure of 2-methylcitrate dehydratase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-methylcitrate dehydratase activity
    		•  2.63183683070179 bayes_pls_golite062009
  • catalytic activity
    		•  0.534516847146079 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle