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Protein Overview: SPK1_ARATH

General Information:
Name(s) found: SPK1_ARATH [Swiss-Prot]
Description(s) found:
Found 8 descriptions.
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  • Guanine nucleotide exchange factor SPIKE 1 OS=Arabidopsis thaliana GN=SPK1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 1830 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDA]
    plasma membrane [IDA]
    Biological Process: NONE FOUND
    Molecular Function: GTP binding [IEA]
    GTPase binding [IEA]
    guanyl-nucleotide exchange factor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENNNLGLRF RKLPRQPLAL PKLDPLLDEN LEQWPHLNQL VQCYGTEWVK DVNKYGHYEN  60
   61 IRPDSFQTQI FEGPDTDTET EIRLASARSA TIEEDVASIS GRPFSDPGSS KHFGQPPLPA 120
  121 YEPAFDWENE RAMIFGQRTP ESPAASYSSG LKISVRVLSL AFQSGLVEPF FGSIALYNQE 180
  181 RKEKLSEDFY FQIQPTEMQD AKLSSENRGV FYLDAPSASV CLLIQLEKTA TEEGGVTSSV 240
  241 YSRKEPVHLT EREKQKLQVW SRIMPYRESF AWAVVPLFDN NLTTNTGESA SPSSPLAPSM 300
  301 TASSSHDGVY EPIAKITSDG KQGYSGGSSV VVEISNLNKV KESYSEESIQ DPKRKVHKPV 360
  361 KGVLRLEIEK HRNGHGDFED LSENGSIIND SLDPTDRLSD LTLMKCPSSS SGGPRNGCSK 420
  421 WNSEDAKDVS RNLTSSCGTP DLNCYHAFDF CSTTRNEPFL HLFHCLYVYP VAVTLSRKRN 480
  481 PFIRVELRKD DTDIRKQPLE AIYPREPGVS LQKWVHTQVA VGARAASYHD EIKVSLPATW 540
  541 TPSHHLLFTF FHVDLQTKLE APRPVVVGYA SLPLSTYIHS RSDISLPVMR ELVPHYLQES 600
  601 TKERLDYLED GKNIFKLRLR LCSSLYPTNE RVRDFCLEYD RHTLQTRPPW GSELLQAINS 660
  661 LKHVDSTALL QFLYPILNML LHLIGNGGET LQVAAFRAMV DILTRVQQVS FDDADRNRFL 720
  721 VTYVDYSFDD FGGNQPPVYP GLATVWGSLA RSKAKGYRVG PVYDDVLSMA WFFLELIVKS 780
  781 MALEQARLYD HNLPTGEDVP PMQLKESVFR CIMQLFDCLL TEVHERCKKG LSLAKRLNSS 840
  841 LAFFCYDLLY IIEPCQVYEL VSLYMDKFSG VCQSVLHECK LTFLQIISDH DLFVEMPGRD 900
  901 PSDRNYLSSI LIQELFLSLD HDELPLRAKG ARILVILLCK HEFDARYQKA EDKLYIAQLY 960
  961 FPFVGQILDE MPVFYNLNAT EKREVLIGVL QIVRNLDDTS LVKAWQQSIA RTRLYFKLME1020
 1021 ECLILFEHKK AADSILGGNN SRGPVSEGAG SPKYSERLSP AINNYLSEAS RQEVRLEGTP1080
 1081 DNGYLWQRVN SQLASPSQPY SLREALAQAQ SSRIGASAQA LRESLHPILR QKLELWEENV1140
 1141 SATVSLQVLE ITENFSSMAA SHNIATDYGK LDCITTILTS FFSRNQSLAF WKAFFPIFNR1200
 1201 IFDLHGATLM ARENDRFLKQ IAFHLLRLAV YRNDSVRKRA VIGLQILVKS SLYFMQTARL1260
 1261 RALLTITLSE LMSDVQVTHM KSDNTLEESG EARRLQQSLS EMADEAKSVN LLRECGLPDD1320
 1321 TLLIIPEKFT ENRWSWAEVK HLSDSLVLAL DASLGHALLG SVMAMDRYAA AESFYKLGMA1380
 1381 FAPVPDLHIM WLLHLCDAHQ EMQSWAEAAQ CAVAVAGVIM QALVARNDGV WSKDHVSALR1440
 1441 KICPMVSGEF TTEASAAEVE GYGASKLTVD SAVKYLQLAN KLFSQAELYH FCASILELVI1500
 1501 PVYKSRKAYG QLAKCHTLLT NIYESILDQE SNPIPFIDAT YYRVGFYGEK FGKLDRKEYV1560
 1561 YREPRDVRLG DIMEKLSHIY ESRMDSNHIL HIIPDSRQVK AEDLQAGVCY LQITAVDAVM1620
 1621 EDEDLGSRRE RIFSLSTGSV RARVFDRFLF DTPFTKNGKT QGGLEDQWKR RTVLQTEGSF1680
 1681 PALVNRLLVT KSESLEFSPV ENAIGMIETR TTALRNELEE PRSSDGDHLP RLQSLQRILQ1740
 1741 GSVAVQVNSG VLSVCTAFLS GEPATRLRSQ ELQQLIAALL EFMAVCKRAI RVHFRLIGEE1800
 1801 DQEFHTQLVN GFQSLTAELS HYIPAILSEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] PSI-BLAST 12.522879 Solution structure of pleckstrin homology domain from human KIAA1058 protein
    2 View Details [73..186] deduced N/A No confident structure predictions are available.
    3 View Details [187..390] MSA 3.111994 View MSA. No confident structure predictions are available.
    4 View Details [391..521] MSA 1.123995 View MSA. No confident structure predictions are available.
    5 View Details [522..715] deduced N/A No confident structure predictions are available.
    6 View Details [716..851] MSA 1.143996 View MSA. No confident structure predictions are available.
    7 View Details [852..912] deduced N/A No confident structure predictions are available.
    8 View Details [913..1126] MSA 1.161996 View MSA. No confident structure predictions are available.
    9 View Details [1127..1359] MSA 1.164979 View MSA. No confident structure predictions are available.
    10 View Details [1360..1478] MSA 1.170987 View MSA. No confident structure predictions are available.
    11 View Details [1479..1530] MSA 2.169992 View MSA. No confident structure predictions are available.
    12 View Details [1531..1608] deduced N/A No confident structure predictions are available.
    13 View Details [1609..1830] Pfam 114.619789 No description for PF06920.5 was found. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

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