Protein Overview: MTHFD1

General Information:
Name(s) found:	MTHFD1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	pir\|\|A31903 methylenetetrahydrofolate dehydrogenase (NADP) (EC 1.5.1.5) - human [NCBI NR] gi\|307178\|gb\|AAA59574.1\| MDMCSF (EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3) [Homo sapiens] [NCBI NR] gi\|115206\|sp\|P11586.3\|C1TC_HUMAN RecName: Full=C-1-tetrahydrofolate synthase, cytoplasmic; Short=C1-THF synthase; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; Includes: R [NCBI NR] methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase [HGNC (HUGO)] C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens GN=MTHFD1 PE=1 SV=3 [Swiss-Prot] methylenetetrahydrofolate dehydrogenase (NADP) (EC 1.5.1.5) - humangi\|307178\|gb\|AAA59574.1\| MDMCSF (EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3)gi\|115206\|sp\|P11586\|C1TC_HUMAN C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrah [nrdb_11152004_Chlamydomonas] C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ; Formyltetrahydrofolate synthetase ] [Yateslab_human_na_07-28-2006_reversed.fasta] MDMCSF (EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic [human-ipi-250309-contam.fasta] IPI:IPI00218342.10\|SWISS-PROT:P11586\|ENSEMBL:ENSP00000216605\|REFSEQ:NP_005947\|H-INV:HIT000191225\|VEGA:OTTHUMP00000180657 Tax_Id=9606 Gene_Symbol=MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic [ipi.HUMAN.fasta.20090807] Tax_Id=9606 C-1-tetrahydrofolate synthase, cytoplasmic [IPI_human_3.26.fasta] Tax_Id=9606 Gene_Symbol=MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic ENSG00000100714 IPI00218342 [drosphohumanreversed.fasta] P11586;B2R5Y2;Q86VC9;Q9BVP5; RecName: Full=C-1-tetrahydrofolate synthase, cytoplasmic; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; Includes: RecName: Full=Formyltetrahydrofolate synthetase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens GN=MTHFD1 [011711_HMR.fasta] C-1-tetrahydrofolate synthase, cytoplasmic GN=MTHFD1 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	935 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA  60
   61 EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP 120
  121 EKDVDGLTSI NAGRLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP 180
  181 MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY 240
  241 VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP 300
  301 GKWMIQYNNL NLKTPVPSDI DISRSCKPKP IGKLAREIGL LSEEVELYGE TKAKVLLSAL 360
  361 ERLKHRPDGK YVVVTGITPT PLGEGKSTTT IGLVQALGAH LYQNVFACVR QPSQGPTFGI 420
  421 KGGAAGGGYS QVIPMEEFNL HLTGDIHAIT AANNLVAAAI DARIFHELTQ TDKALFNRLV 480
  481 PSVNGVRRFS DIQIRRLKRL GIEKTDPTTL TDEEINRFAR LDIDPETITW QRVLDTNDRF 540
  541 LRKITIGQAP TEKGHTRTAQ FDISVASEIM AVLALTTSLE DMRERLGKMV VASSKKGEPV 600
  601 SAEDLGVSGA LTVLMKDAIK PNLMQTLEGT PVFVHAGPFA NIAHGNSSII ADRIALKLVG 660
  661 PEGFVVTEAG FGADIGMEKF FNIKCRYSGL CPHVVVLVAT VRALKMHGGG PTVTAGLPLP 720
  721 KAYIQENLEL VEKGFSNLKK QIENARMFGI PVVVAVNAFK TDTESELDLI SRLSREHGAF 780
  781 DAVKCTHWAE GGKGALALAQ AVQRAAQAPS SFQLLYDLKL PVEDKIRIIA QKIYGADDIE 840
  841 LLPEAQHKAE VYTKQGFGNL PICMAKTHLS LSHNPEQKGV PTGFILPIRD IRASVGAGFL 900
  901 YPLVGTMSTM PGLPTRPCFY DIDLDPETEQ VNGLF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: MTHFD1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: