Protein Overview: TPS1L_ARATH

General Information:
Name(s) found:	TPS1L_ARATH [Swiss-Prot]
Description(s) found: Found 8 descriptions. SHOW ALL	Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic OS=Arabidopsis thaliana GN=TH1 PE=1 SV=1 [Swiss-Prot]
Organism:	Arabidopsis thaliana
Length:	522 amino acids
Gene Ontology:
Cellular Component:	chloroplast [IDA]
Biological Process:	thiamin biosynthetic process [IMP]
Molecular Function:	hydroxymethylpyrimidine kinase activity [IGI] thiamin-phosphate diphosphorylase activity [IDA][IGI] phosphomethylpyrimidine kinase activity [IGI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLGGIRSW PANWRSTTAS MTTTESVRKV PQVLTVAGSD SGAGAGIQAD LKVCAARGVY  60
   61 CASVITAVTA QNTRGVQSVH LLPPEFISEQ LKSVLSDFEF DVVKTGMLPS TEIVEVLLQN 120
  121 LSDFPVRALV VDPVMVSTSG HVLAGSSILS IFRERLLPIA DIITPNVKEA SALLDGFRIE 180
  181 TVAEMRSAAK SLHEMGPRFV LVKGGDLPDS SDSVDVYFDG KEFHELRSPR IATRNTHGTG 240
  241 CTLASCIAAE LAKGSSMLSA VKVAKRFVDN ALDYSKDIVI GSGMQGPFDH FFGLKKDPQS 300
  301 SRCSIFNPDD LFLYAVTDSR MNKKWNRSIV DALKAAIEGG ATIIQLREKE AETREFLEEA 360
  361 KACIDICRSH GVSLLINDRI DIALACDADG VHVGQSDMPV DLVRSLLGPD KIIGVSCKTP 420
  421 EQAHQAWKDG ADYIGSGGVF PTNTKANNRT IGLDGLKEVC EASKLPVVAI GGIGISNAGS 480
  481 VMQIDAPNLK GVAVVSALFD QDCVLTQAKK LHKTLKESKR GI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..304]	PSI-BLAST	59.0	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
2	View Details	[305..522]	PSI-BLAST	44.0	Thiamine phosphate pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
phosphomethylpyrimidine kinase activity	3.972577109569	bayes_pls_golite062009
kinase activity	2.74755351135221	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	2.29466565429735	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.27980720248925	bayes_pls_golite062009
transferase activity	2.15883296431019	bayes_pls_golite062009
catalytic activity	1.74474587246986	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.37866801006693	bayes_pls_golite062009
hydroxyethylthiazole kinase activity	1.28568044601242	bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity	1.27602595951972	bayes_pls_golite062009
carbohydrate kinase activity	1.12876288824319	bayes_pls_golite062009
binding	0.781800306626994	bayes_pls_golite062009
pyridoxal kinase activity	0.217863391052366	bayes_pls_golite062009
protein binding	0.117280046908929	bayes_pls_golite062009

2

Term	Confidence	Notes
thiamin-phosphate diphosphorylase activity	5.90476603396884	bayes_pls_golite062009
phosphomethylpyrimidine kinase activity	1.96653650813022	bayes_pls_golite062009
catalytic activity	1.94308403509017	bayes_pls_golite062009
transferase activity	1.66762065968825	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	0.73172690404654	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	0.429889467826441	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle