YRC Public Data Repository - Protein Structure Prediction

Protein:	Syx6-PB
Organism:	Drosophila melanogaster
Length:	226 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Syx6-PB.

Description	E-value	Query Range	Subject Range
gi\|109099266 - gi\|109099266\|ref\|XP_001111568.1\| PREDICTED: similar to syntaxin 2 isoform 2 [Macaca mulatta]	165.0	[0..13]	[225..164]
gi\|94375456 - gi\|94375456\|ref\|XP_921129.2\| PREDICTED: similar to Epimorphin (Syntaxin-2) [Mus musculus]	154.0	[0..12]	[208..188]
gi\|50759625 - gi\|50759625\|ref\|XP_417710.1\| PREDICTED: similar to guanylate binding protein [Gallus gallus]	152.0	[0..1]	[225..1088]
gi\|73958357 - gi\|73958357\|ref\|XP_547038.2\| PREDICTED: similar to Syntaxin-1B2 (Syntaxin 1B) (P35B) [Canis familiar...	151.0	[0..2]	[205..63]
gi\|531458, gi\|74... - gi\|7447071\|pir\|\|G01485 syntaxin - human, gi\|531458\|gb\|AAA20940.1\| syntaxin [Homo sapiens]	146.0	[0..2]	[221..27]
gi\|118404044, gi... - gi\|118404044\|ref\|NP_001072191.1\| syntaxin 1A (brain) [Xenopus (Silurana) tropicalis], gi\|110645670\|g...	146.0	[0..2]	[221..56]
gi\|220777, gi\|285304 - pir\|\|A38141 neuronal cell membrane antigen HPC-1 - rat (fragment), gi\|220777\|dbj\|BAA01231.1\| HPC-1 ...	145.0	[0..22]	[221..89]

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Predicted Domain #1

Region A:
Residues: [1-226]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDKMSLNRS RDRDITAHQP LLDNDRHSPN HNHSIAIPNS NSNSNEYHQH PHNDRTYLVE  60
   61 CPNGNSLINS GSQVANTIAG TMSAAAAAAS RHSGTKYSKL ENALDSPSHY GQTHHGGMDS 120
  121 PSHRYVGETV SIQQRMIQGQ DEQLDMISDS IGTLKTVSRQ IGVELDEQAV MLDDFGNEFD 180
  181 TTESKLDTTM KKVAKVLHMN NDKRQWAAIL ILSGLLLFVI ILFIIL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	1dn1B
Description:	Syntaxin 1A N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
SNAP receptor activity	3.50393203740159	bayes_pls_golite062009
binding	1.92288664814649	bayes_pls_golite062009
transporter activity	1.74189664015129	bayes_pls_golite062009
protein binding	1.51700626946713	bayes_pls_golite062009
substrate-specific transporter activity	1.2360389745429	bayes_pls_golite062009
transmembrane transporter activity	1.13101548288086	bayes_pls_golite062009
protein transporter activity	0.81087535212264	bayes_pls_golite062009
SNARE binding	0.71459772253941	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.398018181744571	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	0.27873535382283	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	0.27873535382283	bayes_pls_golite062009
ion transmembrane transporter activity	0.0981818568206971	bayes_pls_golite062009
phospholipid binding	0.0172309833091902	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: