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View Structure Prediction Details

Protein: Graf-PE, Graf-PD...
Organism: Drosophila melanogaster
Length: 1016 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Graf-PE, Graf-PD....

Description E-value Query
Range
Subject
Range
gi|109507239, gi... - gi|109507239|ref|XP_001066829.1| PREDICTED: similar to Rho-GTPase-activating protein 26 (Oligophreni...
332.0 [0..4] [632..105]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGGKNVRRG LEPLEFEECI VDSPDFRENL NRHEKELDHT SHQIKRIIKE VKDLMSAAKI  60
   61 LSTRMKQLAI LLNDFNFECI GTAQTDDENV ICESLKRFGA IIGNIEDERE KMLTLADKHI 120
  121 IESLEDFRKK QIGGVKENKK KFDKKTEKFC QSQERFLNMS TKKPENTIQE ADASLGMHER 180
  181 EYIQES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.39794
Match: 2elbA
Description: No description for 2elbA was found.

Predicted functions:

Term Confidence Notes
binding 0.171962044848065 bayes_pls_golite062009
protein binding 0.04256104607293 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [187-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSYVLRIQEV QERIKFEFVE ILLAFISGWL VFYHTAHEQA EDHRDYLQDL RHKVQKTREN  60
   61 FEEAREKVTE LKTKYMEKRT KPEEIFTKRG YLFLMEKKPF KATWTKYYCT FKKQKREFTM 120
  121 LQFNQMNHNF TRPEARDDEK LTLFSCQRRA SEFEKRFCFD LTFKEKPGVV YTFQALSEKD 180
  181 HRYWISAMD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.02
Match: 2elbA
Description: No description for 2elbA was found.

Predicted functions:

Term Confidence Notes
binding 0.46923761062082 bayes_pls_golite062009
protein binding 0.127111860178639 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [376-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTEPTYLAPG KIKVSEAYHL DEAGFMFIRR CIQVLEIRGL EDEGIYRKSG VGTKISKLLA  60
   61 LGLNQKESDD VFVDDKYRDL MESNTIASAL KMYLRNLNEP LMTYQYHSDF IEAAKQETLN 120
  121 QRVNEVHKLV YKLPQPNFQM LDMVICHLTD VSRKYEKNKM SVFNLGVVFG PTLLRPREES 180
  181 VAAILDIKFN NIVINILIDN YERIFKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1f7cA
Description: Graf
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme regulator activity 0.68732227880003 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.590837939249671 bayes_pls_golite062009
GTPase regulator activity 0.59070509814251 bayes_pls_golite062009
enzyme activator activity 0.53004209819211 bayes_pls_golite062009
GTPase activator activity 0.528693496432149 bayes_pls_golite062009
small GTPase regulator activity 0.10243777232979 bayes_pls_golite062009
Ras GTPase activator activity 0.0454578418356197 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [583-845]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPSADIKLPD ATKAPSIMYP SRSSPPTRMP RASQIGKAAS TGAMGSSSNT AGNPMFLNQQ  60
   61 KIYRVVSKTN CTEPTMSSSL QNIPNGDNYA LGSNAMNSSG GAQCISLSPP MHMLNGILSP 120
  121 TIGSINNLHT ISKNETSTRR YVPDTEIAPD YGIIGANNGG VTLQSHHAVP VSSTSNFRHP 180
  181 EYLMTTANPV TQSGSSSHIY TNTSSAGANS SNRISLSNVS PPNTAMRKER FLGSASGPQQ 240
  241 HPPVQRGLHS YGQTKHYSPL MPT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [846-1016]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSSSNDSVC DSLSSNNGLG SSIVANSGNS GNVAQHLSAR NTNDYALISS QNSSLSPHLG  60
   61 PTCDEVVTAT TLPSVSLSCG GTASESTEYP PSKMHRNRDV NQIKRDLSTG TARVRTLYAC 120
  121 MGESEGELSF EPNQIITNVR YSHEPGWLQG TLNGKTGLIP ENYVEHLKPH H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1ycsB
Description: 53BP2
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle