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View Structure Prediction Details

Protein: DNAJB12
Organism: Homo sapiens
Length: 375 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNAJB12.

Description E-value Query
Range
Subject
Range
gi|114631140 - gi|114631140|ref|XP_508164.2| PREDICTED: DnaJ (Hsp40) homolog, subfamily B, member 12 isoform 2 [Pan...
0.0 [1..375] [1..375]
gi|7019854 - gi|7019854|dbj|BAA90896.1| unnamed protein product [Homo sapiens]
0.0 [1..375] [1..375]
gi|73952872 - gi|73952872|ref|XP_861882.1| PREDICTED: similar to DnaJ (Hsp40) homolog, subfamily B, member 12 isof...
0.0 [1..375] [1..373]
gi|83638757 - gi|83638757|gb|AAI09580.1| DNAJB12 protein [Bos taurus]
0.0 [1..373] [1..373]
DJB12_MOUSE - DnaJ homolog subfamily B member 12 OS=Mus musculus GN=Dnajb12 PE=1 SV=2
0.0 [1..375] [1..376]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESNKDEAER CISIALKAIQ SNQPDRALRF LEKAQRLYPT PRVRALIESL NQKPQTAGDQ  60
   61 PPPTDTTHAT HRKAGGTDAP SANGEAGGES TKGYTAEQVA AVKRVKQCKD YYEILGV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1na0A
Description: Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [118-208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRGASDEDLK KAYRRLALKF HPDKNHAPGA TEAFKAIGTA YAVLSNPEKR KQYDQFGDDK  60
   61 SQAARHGHGH GDFHRGFEAD ISPEDLFNMF F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1xblA
Description: NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.53309887293277 bayes_pls_golite062009
binding 1.46542010527547 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [209-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGFPSSNVH VYSNGRMRYT YQQRQDRRDN QGDGGLGVFV QLMPILILIL VSALSQLMVS  60
   61 SPPYSLSPRP SVGHIHRRVT DHLGVVYYVG DTFSEEYTGS SLKTVERNVE DDYIANLRNN 120
  121 CWKEKQQKEG LLYRARYFGD TDMYHRAQKM GTPSCSRLSE VQASLHG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.505 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.448 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.422 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.376 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.359 N/A N/A a.24.17 Group V grass pollen allergen


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle