YRC Public Data Repository - Protein Structure Prediction

Protein:	UCHL5
Organism:	Homo sapiens
Length:	329 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UCHL5.

Description	E-value	Query Range	Subject Range
UCHL5_PIG - Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Sus scrofa GN=UCHL5 PE=2 SV=1 ENSOCUP00000014412 - pep:novel chromosome:oryCun2:16:77766040:77802483:1 gene:ENSOCUG00000016766 transcript:ENSOCUT000000...	487.0	[0..1]	[329..1]
gi\|74006052 - gi\|74006052\|ref\|XP_536116.2\| PREDICTED: similar to ubiquitin C-terminal hydrolase UCH37 [Canis famil...	487.0	[0..1]	[329..1]
UCHL5_MOUSE - Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Mus musculus GN=Uchl5 PE=1 SV=2	486.0	[0..1]	[329..1]
gi\|55859538 - gi\|55859538\|emb\|CAI10828.1\| ubiquitin carboxyl-terminal hydrolase L5 [Homo sapiens] ENSPTRT00000058401 - null	485.0	[0..1]	[329..13]
gi\|61369961, gi\|... - gi\|61369961\|gb\|AAX43419.1\| ubiquitin carboxyl-terminal hydrolase L5 [synthetic construct], gi\|305846...	484.0	[0..1]	[329..1]
gi\|75773502, gi\|... - gi\|76253713\|ref\|NP_776906.2\| ubiquitin carboxyl-terminal hydrolase L5 [Bos taurus], gi\|75773502\|gb\|A...	483.0	[0..1]	[329..1]

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Predicted Domain #1

Region A:
Residues: [1-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP  60
   61 GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120
  121 FDAAMKGLAL SNSDVIRQVH NSFARQQMFE FDTKTSAKEE DAFHFVSYVP VNGRLYELDG 180
  181 LREGPIDLGA CNQDDWISAV RPVIEKRIQK YSEGEIRFNL MAIVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.0
Match:	1uchA
Description:	DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [226-329]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRKMIYEQKI AELQRQLAEE EPMDTDQGNS MLSAIQSEVA KNQMLIEEEV QKLKRYKIEN  60
   61 IRRKHNYLPF IMELLKTLAE HQQLIPLVEK AKEKQNAKKA QETK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.855	N/A	N/A	a.216.1	Description not found.
View	Download	0.814	N/A	N/A	a.70.1	N-terminal domain of the delta subunit of the F1F0-ATP synthase
View	Download	0.806	N/A	N/A	a.24.29	Description not found.
View	Download	0.797	N/A	N/A	a.29.13	Description not found.
View	Download	0.773	N/A	N/A	a.24.4	Hemerythrin
View	Download	0.746	N/A	N/A	a.29.4	RecG, N-terminal domain
View	Download	0.745	N/A	N/A	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.717	N/A	N/A	f.1.4	Bcl-2 inhibitors of programmed cell death

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits