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View Structure Prediction Details

Protein: gi|39777604, gi|...
Organism: Homo sapiens
Length: 879 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|39777604, gi|....

Description E-value Query
Range
Subject
Range
gi|1654344 - gi|1654344|gb|AAB17896.1| guanine nucleotide exchange factor p115-RhoGEF [Homo sapiens]
0.0 [1..879] [1..912]
ARHG1_MOUSE - Rho guanine nucleotide exchange factor 1 OS=Mus musculus GN=Arhgef1 PE=1 SV=2
0.0 [7..874] [6..906]
gi|62751753, gi|... - gi|62751753|ref|NP_067726.3| Rho guanine nucleotide exchange factor (GEF) 1 [Rattus norvegicus], gi|...
0.0 [7..874] [6..905]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE QVKRRPAHLM  60
   61 ALLQHVALQF EPGPLVLRVP VPPNVAFELD RTRADLISED VQRRFVQEVV QSQQVAVGRQ 120
  121 LEDFRSKRLM GMTPWEQELA QLEAWVGRDR ASYEARERHV AERLLMHLEE MQHTISTDEE 180
  181 KSAAVVNAIG LYMRHLGVRT KSGDKKSGRN FFRKKVMGNR 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.30103
Match: 1shzC
Description: Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [221-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSDEPAKTKK GLSSILDAAR WNRGEPQVPD FRHLKAEVDA EKPGATDRKG GVGMPSRDRN  60
   61 IGAPGQDTPG VSLHPLSLDS PDREPGADAP LELGDSSPQG PMSLESLAPP ESTDEGAETE 120
  121 SPEPGDEGEP GRSGLELEPE EPP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.5
Match: 1wckA
Description: Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [364-740]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWRELVPPDT LHSLPKSQVK RQEVISELLV TEAAHVRMLR VLHDLFFQPM AECLFFPLEE  60
   61 LQNIFPSLDE LIEVHSLFLD RLMKRRQESG YLIEEIGDVL LARFDGAEGS WFQKISSRFC 120
  121 SRQSFALEQL KAKQRKDPRF CAFVQEAESR PRCRRLQLKD MIPTEMQRLT KYPLLLQSIG 180
  181 QNTEEPTERE KVELAAECCR EILHHVNQAV RDMEDLLRLK DYQRRLDLSH LRQSSDPMLS 240
  241 EFKNLDITKK KLVHEGPLTW RVTKDKAVEV HVLLLDDLLL LLQRQDERLL LKSHSRTLTP 300
  301 TPDGKTMLRP VLRLTSAMTR EVATDHKAFY VLFTWDQEAQ IYELVAQTVS ERKNWCALIT 360
  361 ETAGSLKVPA PASRPKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.154902
Match: 1txdA
Description: Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [741-879]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPSPSSTREP LLSSSENGNG GRETSPADAR TERILSDLLP FCRPGPEGQL AATALRKVLS  60
   61 LKQLLFPAEE DNGAGPPRDG DGVPGGGPLS PARTQEIQEN LLSLEETMKQ LEELEEEFCR 120
  121 LRPLLSQLGG NSVPQPGCT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle