YRC Public Data Repository - Protein Structure Prediction

Protein:	ACTR8
Organism:	Homo sapiens
Length:	624 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACTR8.

Description	E-value	Query Range	Subject Range
gi\|109489498 - gi\|109489498\|ref\|XP_001076100.1\| PREDICTED: similar to Actin, cytoplasmic 2 (Gamma-actin) [Rattus no...	469.0	[0..112]	[514..309]
gi\|45269029 - gi\|45269029\|gb\|AAS55927.1\| cytoskeletal beta actin [Sus scrofa]	461.0	[0..111]	[500..28]
ACT1_ACACA - Actin-1 OS=Acanthamoeba castellanii PE=1 SV=1	460.0	[0..113]	[500..1]
ACT2_SCHMA - Actin-2 OS=Schistosoma mansoni PE=2 SV=1 gi\|6979994, gi\|1... - gi\|6979994\|gb\|AAF34686.1\| actin [Schistosoma japonicum], gi\|189503078\|gb\|ACE06920.1\| unknown [Schist... gi\|186462275 - gi\|186462275\|gb\|ACC78609.1\| actin [Schistosoma bovis]	460.0	[0..112]	[500..1]
gi\|94373495 - gi\|94373495\|ref\|XP_001052054.1\| PREDICTED: actin, gamma, cytoplasmic 1 [Mus musculus]	459.0	[0..112]	[500..27]
gi\|18565104 - gi\|18565104\|dbj\|BAB84579.1\| Actin 2 [Crassostrea gigas]	459.0	[0..112]	[500..1]
ACT_PLAMG - Actin, adductor muscle OS=Placopecten magellanicus PE=2 SV=1	459.0	[0..112]	[500..1]
ACTG_PELLE - Actin, cytoplasmic 2 OS=Pelophylax lessonae GN=actg1 PE=2 SV=1	458.0	[0..113]	[500..1]

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Predicted Domain #1

Region A:
Residues: [1-97]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQAEKGDTE NGKEKGGEKE KEQRGVKRPI VPALVPESLQ EQIQSNFIIV IHPGSTTLRI  60
   61 GRATDTLPAS IPHVIARRHK QQGQPLYKDS WLLREGL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [98-500]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPESNEQRQ NGLKMVDQAI WSKKMSNGTR RIPVSPEQAR SYNKQMRPAI LDHCSGNKWT  60
   61 NTSHHPEYLV GEEALYVNPL DCYNIHWPIR RGQLNIHPGP GGSLTAVLAD IEVIWSHAIQ 120
  121 KYLEIPLKDL KYYRCILLIP DIYNKQHVKE LVNMILMKMG FSGIVVHQES VCATYGSGLS 180
  181 STCIVDVGDQ KTSVCCVEDG VSHRNTRLCL AYGGSDVSRC FYWLMQRAGF PYRECQLTNK 240
  241 MDCLLLQHLK ETFCHLDQDI SGLQDHEFQI RHPDSPALLY QFRLGDEKLQ APMALFYPAT 300
  301 FGIVGQKMTT LQHRSQGDPE DPHDEHYLLA TQSKQEQSAK ATADRKSASK PIGFEGDLRG 360
  361 QSSDLPERLH SQEVDLGSAQ GDGLMAGNDS EEALTALMSR KTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	129.0
Match:	2oanA
Description:	No description for 2oanA was found.

Predicted Domain #3

Region A:
Residues: [501-624]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISLFEGKALG LDKAILHSID CCSSDDTKKK MYSSILVVGG GLMFHKAQEF LQHRILNKMP  60
   61 PSFRRIIENV DVITRPKDMD PRLIAWKGGA VLACLDTTQE LWIYQREWQR FGVRMLRERA 120
  121 AFVW

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.92
Match:	1k8kA
Description:	Actin-related protein 3, Arp3
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits