YRC Public Data Repository - Protein Structure Prediction

Protein:	CUX1
Organism:	Homo sapiens
Length:	678 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUX1.

Description	E-value	Query Range	Subject Range
gi\|68388302 - gi\|68388302\|ref\|XP_696268.1\| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]	9.0E-97	[1..614]	[2094..2704]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1	3.0E-76	[1..614]	[1092..1708]
gi\|50757621 - gi\|50757621\|ref\|XP_415581.1\| PREDICTED: similar to fast myosin heavy chain isoform 3 [Gallus gallus]	6.0E-76	[8..617]	[1200..1814]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1	7.0E-76	[1..614]	[1093..1709]
MYH1_BOVIN - Myosin-1 OS=Bos taurus GN=MYH1 PE=2 SV=2	8.0E-76	[1..614]	[1093..1709]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult h0010399 - null	8.0E-76	[1..614]	[1094..1710]
gi\|109113339 - gi\|109113339\|ref\|XP_001118262.1\| PREDICTED: myosin, heavy polypeptide 2, skeletal muscle, adult [Mac...	1.0E-75	[1..614]	[849..1465]

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Predicted Domain #1

Region A:
Residues: [1-171]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL  60
   61 RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH 120
  121 DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET I

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.75
Match:	1jchA
Description:	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [172-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALEKEQKLQN DFAEKERKLQ ETQMSTTSKL EEAEHKVQSL QTALEKTRTE LFDLKTKYDE  60
   61 ETTAKADEIE MIMTDLERAN QRAEVAQREA ETLREQLSSA NHSLQLASQI QKAP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.69897
Match:	2dfsA
Description:	No description for 2dfsA was found.

Predicted Domain #3

Region A:
Residues: [286-614]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVEQAIEVLT RSSLEVELAA KEREIAQLVE DVQRLQASLT KLRENSASQI SQLEQQLSAK  60
   61 NSTLKQLEEK LKGQADYEEV KKELNILKSM EFAPSEGAGT QDAAKPLEVL LLEKNRSLQS 120
  121 ENAALRISNS DLSGRCAELQ VRITEAVATA TEQRELIARL EQDLSIIQSI QRPDAEGAAE 180
  181 HRLEKIPEPI KEATALFYGP AAPASGALPE GQVDSLLSII SSQRERFRAR NQELEAENRL 240
  241 AQHTLQALQS ELDSLRADNI KLFEKIKFLQ SYPGRGSGSD DTELRYSSQY EERLDPFSSF 300
  301 SKRERQRKYL SLSPWDKATL SMGRLVLSN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.09691
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [615-678]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMARTIGFFY TLFLHCLVFL VLYKLAWSES MERDCATFCA KKFADHLHKF HENDNGAAAG  60
   61 DLWQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.09691
Match:	2b5uA
Description:	No description for 2b5uA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits