YRC Public Data Repository - Protein Structure Prediction

Protein:	ASL
Organism:	Homo sapiens
Length:	464 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASL.

Description	E-value	Query Range	Subject Range
gi\|115905869, gi... - gi\|115951613\|ref\|XP_001193429.1\| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus], gi...	0.0	[2..462]	[115..575]
gi\|114613790 - gi\|114613790\|ref\|XP_519125.2\| PREDICTED: argininosuccinate lyase [Pan troglodytes]	0.0	[1..464]	[153..616]
ARLY_PSESM - Argininosuccinate lyase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=argH PE=3 SV=1 ARLY_PSESM - Argininosuccinate lyase OS=Pseudomonas syringae pv. tomato GN=argH PE=3 SV=1	0.0	[1..462]	[1..464]
ARLY_PSE14 - Argininosuccinate lyase OS=Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) GN=argH P...	0.0	[1..462]	[1..464]
gi\|84317867, gi\|... - gi\|84317867\|ref\|ZP_00966302.1\| COG0165: Argininosuccinate lyase [Pseudomonas aeruginosa C3719], gi\|2... ARLY_PSEAE - Argininosuccinate lyase OS=Pseudomonas aeruginosa GN=argH PE=3 SV=2 ARLY_PSEAE - Argininosuccinate lyase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 122...	0.0	[1..462]	[1..464]
gi\|107104365 - gi\|107104365\|ref\|ZP_01368283.1\| hypothetical protein PaerPA_01005440 [Pseudomonas aeruginosa PACS2]	0.0	[1..462]	[1..464]
ARLY_PSEAB - Argininosuccinate lyase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=argH PE=3 SV=1 gi\|126197231, gi... - gi\|84324032\|ref\|ZP_00972097.1\| COG0165: Argininosuccinate lyase [Pseudomonas aeruginosa 2192], gi\|25...	0.0	[1..462]	[1..464]
ARLY_NITOC - Argininosuccinate lyase OS=Nitrosococcus oceani (strain ATCC 19707 / NCIMB 11848) GN=argH PE=3 SV=1 gi\|207089381 - gi\|207089381\|gb\|EDZ66653.1\| argininosuccinate lyase [Nitrosococcus oceani AFC27] gi\|254436270, gi... - gi\|254436270\|ref\|ZP_05049777.1\| argininosuccinate lyase [Nitrosococcus oceani AFC27], gi\|224409727\|r...	0.0	[2..459]	[5..463]
gi\|148545463, gi... - gi\|82737852\|ref\|ZP_00900696.1\| Argininosuccinate lyase [Pseudomonas putida F1], gi\|82715091\|gb\|EAP50...	0.0	[1..462]	[36..499]
gi\|98660428 - gi\|98660428\|dbj\|GAA02348.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	0.0	[7..462]	[6..462]

Back

Predicted Domain #1

Region A:
Residues: [1-464]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM  60
   61 DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD 120
  121 LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL 180
  181 TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA 240
  241 EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA 300
  301 GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM 360
  361 GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF 420
  421 SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	136.0
Match:	1aosA
Description:	Argininosuccinate lyase/delta-crystallin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
amidine-lyase activity	3.84281419858187	bayes_pls_golite062009
argininosuccinate lyase activity	3.58328346705456	bayes_pls_golite062009
catalytic activity	2.51282259572665	bayes_pls_golite062009
lyase activity	2.31268471569846	bayes_pls_golite062009
carbon-nitrogen lyase activity	2.2046475419807	bayes_pls_golite062009
fumarate hydratase activity	1.8220456742683	bayes_pls_golite062009
histidine ammonia-lyase activity	0.948129236753279	bayes_pls_golite062009
binding	0.616567403608599	bayes_pls_golite062009
ammonia-lyase activity	0.491229595527877	bayes_pls_golite062009
protein binding	0.110986062813054	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: