YRC Public Data Repository - Protein Structure Prediction

Protein:	CHMP7
Organism:	Homo sapiens
Length:	453 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CHMP7.

Description	E-value	Query Range	Subject Range
gi\|114619256 - gi\|114619256\|ref\|XP_001158823.1\| PREDICTED: CHMP family, member 7 isoform 4 [Pan troglodytes]	430.0	[0..1]	[453..1]
CHMP7_PONPY - Charged multivesicular body protein 7 - Pongo pygmaeus (Orangutan) CHMP7_PONAB - Charged multivesicular body protein 7 OS=Pongo abelii GN=CHMP7 PE=2 SV=1	427.0	[0..1]	[453..1]
gi\|61823217, gi\|... - gi\|61823217\|ref\|XP_615505.1\| PREDICTED: hypothetical protein isoform 2 [Bos taurus], gi\|149642791\|re...	420.0	[0..1]	[450..1]
gi\|149049867, gi... - gi\|34875283\|ref\|XP_344431.1\| PREDICTED: similar to CHMP family, member 7 [Rattus norvegicus], gi\|157...	418.0	[0..1]	[450..1]
CHMP7_MOUSE - Charged multivesicular body protein 7 OS=Mus musculus GN=Chmp7 PE=1 SV=1	415.0	[0..1]	[450..1]
gi\|52545842 - gi\|52545842\|emb\|CAD38703.2\| hypothetical protein [Homo sapiens]	415.0	[0..1]	[453..1]
gi\|73994030 - gi\|73994030\|ref\|XP_851170.1\| PREDICTED: similar to CHMP family, member 7 [Canis familiaris]	409.0	[0..1]	[434..1]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWSPEREAEA PAGGDPAGLL PPEWEEDEER MSFLFSAFKR SREVNSTDWD SKMGFWAPLV  60
   61 LSHSRRQGVV RLRLRDLQEA FQRKGSVPLG LATVLQDLLR RGELQRESDF MASVDSSWIS 120
  121 WGVGVFLLKP LKWTLSNMLG D

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.638	N/A	N/A	c.78.1	Aspartate/ornithine carbamoyltransferase
View	Download	0.510	N/A	N/A	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.475	N/A	N/A	a.118.8	TPR-like
View	Download	0.416	N/A	N/A	a.118.8	TPR-like
View	Download	0.414	N/A	N/A	c.3.1	FAD/NAD(P)-binding domain
View	Download	0.399	N/A	N/A	a.59.1	PAH2 domain
View	Download	0.307	N/A	N/A	d.58.33	Formylmethanofuran:tetrahydromethanopterin formyltransferase
View	Download	0.294	N/A	N/A	a.118.9	ENTH/VHS domain
View	Download	0.263	N/A	N/A	a.1.1	Globin-like

Predicted Domain #2

Region A:
Residues: [142-453]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKVPAEEVLV AVELLKEKAE EVYRLYQNSP LSSHPVVALS ELSTLCANSC PDERTFYLVL  60
   61 LQLQKEKRVT VLEQNGEKIV KFARGPRAKV SPVNDVDVGV YQLMQSEQLL SRKVESLSQE 120
  121 AERCKEEARR ACRAGKKQLA LRSLKAKQRT EKRIEALHAK LDTVQGILDR IYASQTDQMV 180
  181 FNAYQAGVGA LKLSMKDVTV EKAESLVDQI QELCDTQDEV SQTLAGGVTN GLDFDSEELE 240
  241 KELDILLQDT TKEPLDLPDN PRNRHFTNSV PNPRISDAEL EAELEKLSLS EGGLVPSSKS 300
  301 PKRQLEPTLK PL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.221849
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits