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View Structure Prediction Details

Protein: DUSP7
Organism: Homo sapiens
Length: 368 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DUSP7.

Description E-value Query
Range		 Subject
Range
gi|109039255 - gi|109039255|ref|XP_001091142.1| PREDICTED: similar to dual specificity phosphatase 7 [Macaca mulatt...
 2.0E-75 [1..368] [1..368]
gi|73985361 - gi|73985361|ref|XP_541858.2| PREDICTED: similar to dual specificity phosphatase 7 isoform 1 [Canis f...
 2.0E-75 [1..368] [39..406]
gi|149018678, gi... - gi|149018678|gb|EDL77319.1| dual specificity phosphatase 7 [Rattus norvegicus], gi|109485240|ref|XP_...
 2.0E-75 [1..368] [52..419]
DUS7_MOUSE - Dual specificity protein phosphatase 7 OS=Mus musculus GN=Dusp7 PE=2 SV=3
 3.0E-75 [1..368] [1..368]
gi|60099237 - gi|60099237|emb|CAH65449.1| hypothetical protein [Gallus gallus]
 1.0E-71 [1..368] [18..382]
gi|114587122 - gi|114587122|ref|XP_526209.2| PREDICTED: dual specificity phosphatase 7 [Pan troglodytes]
 8.0E-70 [13..368] [115..468]

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Predicted Domain #1
Region A:
Residues: [1-141] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPCKSAEWLQ EELEARGGAS LLLLDCRPHE LFESSHIETA INLAIPGLML RRLRKGNLPI  60
   61 RSIIPNHADK ERFATRCKAA TVLLYDEATA EWQPEPGAPA SVLGLLLQKL RDDGCQAYYL 120
  121 QGGFNKFQTE YSEHCETNVD S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1hzmA
Description: Erk2 binding domain of Mapk phosphatase mkp-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 4.79074052803751 bayes_pls_golite062009
phosphatase activity 4.46276380920308 bayes_pls_golite062009
phosphoric ester hydrolase activity 4.26891308022499 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 3.37977783690618 bayes_pls_golite062009
protein tyrosine phosphatase activity 3.24783194678996 bayes_pls_golite062009
binding 1.72957395505299 bayes_pls_golite062009
protein binding 1.56606332199727 bayes_pls_golite062009
transferase activity 1.00600613068372 bayes_pls_golite062009
catalytic activity 0.687308230067573 bayes_pls_golite062009
hydrolase activity 0.683726977291316 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [142-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSPSSSPPT SVLGLGGLRI SSDCSDGESD RELPSSATES DGSPVPSSQP AFPVQILPYL  60
   61 YLGCAKDSTN LDVLGKYGIK YILNVTPNLP NAFEHGGEFT YKQIPISDHW SQNLS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.26
Match: 2pq5A
Description: No description for 2pq5A was found.

Predicted Domain #3
Region A:
Residues: [257-368] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFFPEAISFI DEARSKKCGV LVHCLAGISR SVTVTVAYLM QKMNLSLNDA YDFVKRKKSN  60
   61 ISPNFNFMGQ LLDFERTLGL SSPCDNHASS EQLYFSTPTN HNLFPLNTLE ST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 2hxpA
Description: No description for 2hxpA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle