YRC Public Data Repository - Protein Structure Prediction

Protein:	ZRAS_ECOLI
Organism:	Escherichia coli
Length:	465 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZRAS_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|82778821, gi\|... - gi\|82778821\|ref\|YP_405170.1\| sensor protein ZraS [Shigella dysenteriae Sd197], gi\|81242969\|gb\|ABB636...	292.0	[0..1]	[465..1]
gi\|209921483, gi... - gi\|209921483\|ref\|YP_002295567.1\| sensor protein ZraS [Escherichia coli SE11], gi\|209914742\|dbj\|BAG79... gi\|75255500, gi\|... - gi\|75255500\|ref\|ZP_00727299.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],... gi\|190901296, gi... - gi\|75228126\|ref\|ZP_00714795.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B7A],... gi\|194412002, gi... - gi\|75208801\|ref\|ZP_00709087.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|157069152, gi... - gi\|75197867\|ref\|ZP_00707937.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ... gi\|218363327, gi... - gi\|218556558\|ref\|YP_002389472.1\| sensor protein ZraS [Escherichia coli IAI1], gi\|218363327\|emb\|CAR00...	291.0	[0..1]	[465..1]
gi\|75179636, gi\|... - gi\|75179636\|ref\|ZP_00699640.1\| COG0642: Signal transduction histidine kinase [Shigella boydii BS512]...	291.0	[0..1]	[465..1]
gi\|30042975, gi\|... - gi\|30064715\|ref\|NP_838886.1\| sensor protein ZraS [Shigella flexneri 2a str. 2457T], gi\|30042975\|gb\|A... gi\|24115287, gi\|... - gi\|24115287\|ref\|NP_709797.1\| sensor protein ZraS [Shigella flexneri 2a str. 301], gi\|24054582\|gb\|AAN...	291.0	[0..1]	[465..1]
gi\|193067899, gi... - gi\|75238544\|ref\|ZP_00722533.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E1100...	291.0	[0..1]	[465..1]
gi\|81247756, gi\|... - gi\|82546345\|ref\|YP_410292.1\| sensor protein ZraS [Shigella boydii Sb227], gi\|81247756\|gb\|ABB68464.1\|...	290.0	[0..1]	[465..1]
gi\|83569021, gi\|... - gi\|83569021\|ref\|ZP_00920484.1\| COG0642: Signal transduction histidine kinase [Shigella dysenteriae 1...	290.0	[0..1]	[465..1]
gi\|157079612, gi... - gi\|75188733\|ref\|ZP_00702000.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E2437...	289.0	[0..1]	[465..1]
gi\|73857974, gi\|... - gi\|74314497\|ref\|YP_312916.1\| sensor protein ZraS [Shigella sonnei Ss046], gi\|73857974\|gb\|AAZ90681.1\|...	289.0	[0..1]	[465..1]
gi\|91074364, gi\|... - gi\|91212790\|ref\|YP_542776.1\| sensor protein ZraS [Escherichia coli UTI89], gi\|91074364\|gb\|ABE09245.1... gi\|237702770, gi... - gi\|237702770\|ref\|ZP_04533251.1\| sensor protein ZraS [Escherichia sp. 3_2_53FAA], gi\|226903083\|gb\|EEH... gi\|115515389, gi... - gi\|117626265\|ref\|YP_859588.1\| sensor protein ZraS [Escherichia coli APEC O1], gi\|115515389\|gb\|ABJ034... gi\|218561069, gi... - gi\|218561069\|ref\|YP_002393982.1\| sensor protein ZraS [Escherichia coli S88], gi\|218367838\|emb\|CAR056...	288.0	[0..1]	[465..1]

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Predicted Domain #1

Region A:
Residues: [1-195]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFMQRSKDS LAKWLSAILP VVIVGLVGLF AVTVIRDYGR ASEADRQALL EKGNVLIRAL  60
   61 ESGSRVGMGM RMHHVQQQAL LEEMAGQPGV LWFAVTDAQG IIILHSDPDK VGRALYSPDE 120
  121 MQKLKPEENS RWRLLGKTET TPALEVYRLF QPMSAPWRHG MHNMPRCNGK AVPQVDAQQA 180
  181 IFIAVDASDL VATQS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.38
Match:	1ojgA
Description:	Sensory domain of the membraneous two-component fumarate sensor DcuS of E. Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component sensor activity	2.88093868237858	bayes_pls_golite062009
protein histidine kinase activity	2.86151216540335	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.80671328721504	bayes_pls_golite062009
protein kinase activity	1.74105675066805	bayes_pls_golite062009
two-component response regulator activity	1.62873572477094	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.58981311381645	bayes_pls_golite062009
kinase activity	1.5133458700147	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.31628115739307	bayes_pls_golite062009
signal transducer activity	1.10204821596482	bayes_pls_golite062009
molecular transducer activity	1.10204821596482	bayes_pls_golite062009
catalytic activity	0.970922685016416	bayes_pls_golite062009
transferase activity	0.839270468560673	bayes_pls_golite062009
binding	0.704248066961418	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [196-465]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEKRNTLIIL FALATVLLAS VLSFFWYRRY LRSRQLLQDE MKRKEKLVAL GHLAAGVAHE  60
   61 IRNPLSSIKG LAKYFAERAP AGGEAHQLAQ VMAKEADRLN RVVSELLELV KPTHLALQAV 120
  121 DLNTLINHSL QLVSQDANSR EIQLRFTAND TLPEIQADPD RLTQVLLNLY LNAIQAIGQH 180
  181 GVISVTASES GAGVKISVTD SGKGIAADQL DAIFTPYFTT KAEGTGLGLA VVHNIVEQHG 240
  241 GTIQVASQEG KGSTFTLWLP VNITRKDPQG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.522879
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: