YRC Public Data Repository - Protein Structure Prediction

Protein:	YQHD_ECOLI
Organism:	Escherichia coli
Length:	387 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YQHD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77995475, gi\|... - gi\|78043360\|ref\|YP_359772.1\| putative lactaldehyde reductase [Carboxydothermus hydrogenoformans Z-29...	378.0	[0..1]	[386..1]
gi\|241903602, gi... - gi\|241903602\|ref\|ZP_04788323.1\| iron-containing alcohol dehydrogenase [Thermoanaerobacter brockii su... gi\|76588428, gi\|... - gi\|76796158\|ref\|ZP_00778525.1\| Iron-containing alcohol dehydrogenase [Thermoanaerobacter ethanolicus...	373.0	[0..3]	[386..467]
gi\|114845300, gi... - gi\|167039286\|ref\|YP_001662271.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Thermoanaeroba...	373.0	[0..3]	[386..467]
gi\|111143367 - gi\|111143367\|gb\|ABH06551.1\| alcohol/aldehyde dehydrogenase [Thermoanaerobacter ethanolicus]	370.0	[0..3]	[386..467]
gi\|89210581, gi\|... - gi\|89210581\|ref\|ZP_01188969.1\| Iron-containing alcohol dehydrogenase:Aldehyde dehydrogenase [Halothe...	368.0	[0..3]	[386..470]
gi\|90311944, gi\|... - gi\|90406902\|ref\|ZP_01215093.1\| putative alcohol dehydrogenase [Psychromonas sp. CNPT3], gi\|90311944\|...	365.0	[0..2]	[386..1]
gi\|98660195 - gi\|98660195\|dbj\|GAA02506.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	365.0	[0..2]	[386..46]
gi\|52307909, gi\|... - gi\|52425857\|ref\|YP_088994.1\| EutG protein [Mannheimia succiniciproducens MBEL55E], gi\|52307909\|gb\|AA...	364.0	[0..2]	[386..6]
gi\|254228886, gi... - gi\|75856694\|ref\|ZP_00764318.1\| COG1454: Alcohol dehydrogenase, class IV [Vibrio sp. Ex25], gi\|254228...	361.0	[0..2]	[386..1]

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Predicted Domain #1

Region A:
Residues: [1-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNFNLHTPT RILFGKGAIA GLREQIPHDA RVLITYGGGS VKKTGVLDQV LDALKGMDVL  60
   61 EFGGIEPNPA YETLMNAVKL VREQKVTFLL AVGGGSVLDG TKFIAAAANY PENIDPWHIL 120
  121 QTGGKEIKSA IPMGCVLTLP ATGSESNAGA VISRKTTGDK QAFHSAHVQP VFAVLDPVYT 180
  181 YTLPPRQVAN GVVDAFVHTV EQYVTKPVDA KIQDRFAEGI LLTLIEDGPK ALKEPENYDV 240
  241 RANVMWAATQ ALNGLIGAGV PQDWATHMLG HELTAMHGLD HAQTLAIVLP ALWNEKRDTK 300
  301 RAKLLQYAER VWNITEGSDD ERIDAAIAAT RNFFEQLGVP THLSDYGLDG SSIPALLKKL 360
  361 EEHGMTQLGE NHDITLDVSR RIYEAAR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.0
Match:	1oj7A
Description:	STRUCTURAL GENOMICS, UNKNOWN FUNCTION CRYSTAL STRUCTURE OF E. COLI K-12 YQHD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
alcohol dehydrogenase (NAD) activity	4.00011629375661	bayes_pls_golite062009
oxidoreductase activity	3.07409531087588	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.83823088483915	bayes_pls_golite062009
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	2.10085302216488	bayes_pls_golite062009
binding	1.15096180564234	bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity	0.831155115586418	bayes_pls_golite062009
protein binding	0.295023706645045	bayes_pls_golite062009
hydroxyacid-oxoacid transhydrogenase activity	0.146499147589879	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0904828025133766	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: