YRC Public Data Repository - Protein Structure Prediction

Protein:	YOJN_ECOLI
Organism:	Escherichia coli
Length:	890 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOJN_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91073084, gi\|... - gi\|91211510\|ref\|YP_541496.1\| phosphotransfer intermediate protein in two-component regulatory system... gi\|115513534, gi... - gi\|117624410\|ref\|YP_853323.1\| phosphotransfer intermediate protein in two-component regulatory syste... gi\|218559134, gi... - gi\|218559134\|ref\|YP_002392047.1\| phosphotransfer intermediate protein in two-component regulatory sy... gi\|226901057, gi... - gi\|237704691\|ref\|ZP_04535172.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22690...	505.0	[0..1]	[890..1]
gi\|190909536, gi... - gi\|75243032\|ref\|ZP_00726738.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|227887274, gi... - gi\|227887274\|ref\|ZP_04005079.1\| histidine kinase [Escherichia coli 83972], gi\|227835624\|gb\|EEJ46090.... gi\|26109010, gi\|... - gi\|26248605\|ref\|NP_754645.1\| phosphotransfer intermediate protein in two-component regulatory system... gi\|110344018, gi... - gi\|110642426\|ref\|YP_670156.1\| phosphotransfer intermediate protein in two-component regulatory syste...	504.0	[0..1]	[890..1]
gi\|12516551, gi\|... - gi\|15802769\|ref\|NP_288796.1\| phosphotransfer intermediate protein in two-component regulatory system... gi\|168749624, gi... - gi\|188016093\|gb\|EDU54215.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|168754968, gi... - gi\|189357604\|gb\|EDU76023.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|13362574, gi\|... - gi\|15832359\|ref\|NP_311132.1\| phosphotransfer intermediate protein in two-component regulatory system... gi\|208738360, gi... - gi\|208818237\|ref\|ZP_03258557.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4042],... gi\|209161825, gi... - gi\|209400425\|ref\|YP_002271630.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4115]... gi\|168798386, gi... - gi\|189378886\|gb\|EDU97302.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|195935597 - gi\|195935597\|ref\|ZP_03080979.1\| phosphotransfer intermediate protein in two-component regulatory sys... gi\|208726220, gi... - gi\|208806419\|ref\|ZP_03248756.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4206],... gi\|254794116, gi... - gi\|254794116\|ref\|YP_003078953.1\| phosphotransfer intermediate protein in two-component regulatory sy... gi\|208734766, gi... - gi\|208813489\|ref\|ZP_03254818.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4045],... gi\|189362880, gi... - gi\|189362880\|gb\|EDU81299.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4486], gi\|... gi\|187771243, gi... - gi\|187771243\|gb\|EDU35087.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|13362574, gi\|... - gi\|15832359\|ref\|NP_311132.1\| putative 2-component sensor protein [Escherichia coli O157:H7], gi\|1336... gi\|168780070, gi... - gi\|189001949\|gb\|EDU70935.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|209765630, gi... - pir\|\|C85861 probable 2-component sensor protein yojN [imported] - Escherichia coli (strain O157:H7, ... gi\|168787127, gi... - gi\|189372851\|gb\|EDU91267.1\| sensor histidine kinase YojN [Escherichia coli O157:H7 str. EC869], gi\|1...	504.0	[0..1]	[890..1]
gi\|74312738, gi\|... - gi\|74312738\|ref\|YP_311157.1\| phosphotransfer intermediate protein in two-component regulatory system...	503.0	[0..1]	[890..1]
gi\|124501856, gi... - gi\|124526385\|ref\|ZP_01698338.1\| Hpt sensor signal transduction histidine kinase [Escherichia coli B]... gi\|188487955, gi... - gi\|75514420\|ref\|ZP_00736698.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638... gi\|170019470, gi... - gi\|170019470\|ref\|YP_001724424.1\| phosphotransfer intermediate protein in two-component regulatory sy...	503.0	[0..1]	[890..1]
gi\|157161699, gi... - gi\|75196259\|ref\|ZP_00706329.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ...	503.0	[0..1]	[890..1]
gi\|75231446, gi\|... - gi\|75231446\|ref\|ZP_00717815.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B7A],... gi\|157154810, gi... - gi\|75187012\|ref\|ZP_00700279.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E2437...	503.0	[0..1]	[890..1]
gi\|194427207, gi... - gi\|75211633\|ref\|ZP_00711712.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|75259689, gi\|... - gi\|75259689\|ref\|ZP_00730991.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],... gi\|193068198, gi... - gi\|75238013\|ref\|ZP_00722018.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E1100...	502.0	[0..1]	[890..1]
gi\|30041908, gi\|... - gi\|30063655\|ref\|NP_837826.1\| phosphotransfer intermediate protein in two-component regulatory system...	501.0	[0..1]	[890..1]
gi\|82776178, gi\|... - gi\|82776178\|ref\|YP_402527.1\| phosphotransfer intermediate protein in two-component regulatory system...	501.0	[0..1]	[890..1]

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Predicted Domain #1

Region A:
Residues: [1-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQKETTATT RFSLLPGSIT RFFLLLIIVL LVTMGVMVQS AVNAWLKDKS YQIVDITHAI  60
   61 QKRVDNWRYV TWQIYDNIAA TTSPSSGEGL QETRLKQDVY YLEKPRRKTE ALIFGSHDNS 120
  121 TLEMTQRMST YLDTLWGAEN VPWSMYYLNG QDNSLVLIST LPLKDLTSGF KESTVSDIVD 180
  181 SRRAEMLQQA NALDERESFS NMRRLAWQNG HYFTLRTTFN QPGHLATVVA FDLPINDLIP 240
  241 PGMPLDSFRL EPDATATGNN DNEKEGTDS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [270-438]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSIHFNSTKI EISSALNSTD MRLVWQVPYG TLLLDTLQNI LLPLLLNIGL LALALFGYTT  60
   61 FRHFSSRSTE NVPSTAVNNE LRILRAINEE IVSLLPLGLL VHDQESNRTV ISNKIADHLL 120
  121 PHLNLQNITT MAEQHQGIIQ ATINNELYEI RMFRSQVAPR TQIFIIRDQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.30103
Match:	1d06A
Description:	Histidine kinase FixL heme domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.438711522487185	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [439-683]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DREVLVNKKL KQAQRLYEKN QQGRMIFMKN IGDALKEPAQ SLAESAAKLN APESKQLANQ  60
   61 ADVLVRLVDE IQLANMLADD SWKSETVLFS VQDLIDEVVP SVLPAIKRKG LQLLINNHLK 120
  121 AHDMRRGDRD ALRRILLLLM QYAVTSTQLG KITLEVDQDE SSEDRLTFRI LDTGEGVSIH 180
  181 EMDNLHFPFI NQTQNDRYGK ADPLAFWLSD QLARKLGGHL NIKTRDGLGT RYSVHIKMLA 240
  241 ADPEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.69897
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [684-890]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEEERLLDD VCVMVDVTSA EIRNIVTRQL ENWGATCITP DERLISQDYD IFLTDNPSNL  60
   61 TASGLLLSDD ESGVREIGPG QLCVNFNMSN AMQEAVLQLI EVQLAQEEVT ESPLGGDENA 120
  121 QLHASGYYAL FVDTVPDDVK RLYTEAATSD FAALAQTAHR LKGVFAMLNL VPGKQLCETL 180
  181 EHLIREKDVP GIEKYISDID SYVKSLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.522879
Match:	2oqrA
Description:	No description for 2oqrA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: