YRC Public Data Repository - Protein Structure Prediction

Protein:	YIEO_ECOLI
Organism:	Escherichia coli
Length:	475 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YIEO_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|60467752, gi\|... - gi\|60467752\|gb\|EAL65769.1\| hypothetical protein DDB0191430 [Dictyostelium discoideum], gi\|29500764\|g... gi\|60467752, gi\|... - gi\|66810832\|ref\|XP_639123.1\| major facilitator superfamily transporter [Dictyostelium discoideum AX4...	287.0	[0..5]	[426..596]
gi\|46107656, gi\|... - gi\|46107656\|ref\|XP_380887.1\| hypothetical protein FG00711.1 [Gibberella zeae PH-1], gi\|42547814\|gb\|E...	283.0	[0..26]	[416..1460]
gi\|70725707, gi\|... - gi\|70725707\|ref\|YP_252621.1\| hypothetical protein SH0706 [Staphylococcus haemolyticus JCSC1435], gi\|...	281.0	[0..9]	[462..179]
gi\|25498023 - pir\|\|D96902 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15893318, gi\|... - gi\|15893318\|ref\|NP_346667.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15022839\|gb...	265.0	[0..7]	[416..4]
gi\|54026956, gi\|... - gi\|54026956\|ref\|YP_121198.1\| putative transporter [Nocardia farcinica IFM 10152], gi\|54018464\|dbj\|BA...	253.0	[0..2]	[422..11]
gi\|251804540, gi... - gi\|251811941\|ref\|ZP_04826414.1\| MFS family major facilitator transporter, multidrug:cation symporter... gi\|57636029, gi\|... - gi\|57865371\|ref\|YP_189502.1\| EmrB/QacA family drug resistance transporter [Staphylococcus epidermidi...	251.0	[0..9]	[425..151]
gi\|27316398, gi\|... - gi\|27468850\|ref\|NP_765487.1\| multidrug resistance protein [Staphylococcus epidermidis ATCC 12228], g...	250.0	[0..9]	[425..151]
gi\|73661859, gi\|... - gi\|73661859\|ref\|YP_300640.1\| major facilitator superfamily permease [Staphylococcus saprophyticus su...	245.0	[0..12]	[426..140]
gi\|115250420, gi... - gi\|126698983\|ref\|YP_001087880.1\| putative transporter [Clostridium difficile 630], gi\|115250420\|emb\|...	243.0	[0..5]	[420..16]
gi\|90205974, gi\|... - gi\|90205974\|ref\|ZP_01208611.1\| Drug resistance transporter EmrB/QacA subfamily [Mycobacterium vanbaa...	239.0	[0..2]	[450..61]

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Predicted Domain #1

Region A:
Residues: [1-475]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKKKRSMA GLPWIAAMAF FMQALDATIL NTALPAIAHS LNRSPLAMQS AIISYTLTVA  60
   61 MLIPVSGWLA DRFGTRRIFT LAVSLFTLGS LACALSNSLP QLVVFRVIQG IGGAMMMPVA 120
  121 RLALLRAYPR NELLPVLNFV AMPGLVGPIL GPVLGGVLVT WATWHWIFLI NIPIGIAGLL 180
  181 YARKHMPNFT TARRRFDITG FLLFGLSLVL FSSGIELFGE KIVASWIALT VIVTSIGLLL 240
  241 LYILHARRTP NPLISLDLFK TRTFSIGIVG NIATRLGTGC VPFLMPLMLQ VGFGYQAFIA 300
  301 GCMMAPTALG SIIAKSMVTQ VLRRLGYRHT LVGITVIIGL MIAQFSLQSP AMAIWMLILP 360
  361 LFILGMAMST QFTAMNTITL ADLTDDNASS GNSVLAVTQQ LSISLGVAVS AAVLRVYEGM 420
  421 EGTTTVEQFH YTFITMGIIT VASAAMFMLL KTTDGNNLIK RQRKSKPNRV PSESE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	26.0
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
binding	0.805286077372817	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: