YRC Public Data Repository - Protein Structure Prediction

Protein:	YGGW_ECOLI
Organism:	Escherichia coli
Length:	378 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGGW_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|37525144, gi\|... - gi\|37525144\|ref\|NP_928488.1\| coproporphyrinogen III oxidase [Photorhabdus luminescens subsp. laumond...	356.0	[0..1]	[376..1]
gi\|110344696, gi... - gi\|110643104\|ref\|YP_670834.1\| coproporphyrinogen III oxidase [Escherichia coli 536], gi\|110344696\|gb... gi\|75241249, gi\|... - gi\|75241249\|ref\|ZP_00725111.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta...	356.0	[0..1]	[378..1]
gi\|189358465, gi... - gi\|189358465\|gb\|EDU76884.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|168747553, gi... - gi\|188017808\|gb\|EDU55930.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|168781814, gi... - gi\|189000657\|gb\|EDU69643.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|254594307, gi... - gi\|254794907\|ref\|YP_003079744.1\| predicted oxidoreductase [Escherichia coli O157:H7 str. TW14359], g... gi\|187770940, gi... - gi\|187770940\|gb\|EDU34784.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|189363639, gi... - gi\|189363639\|gb\|EDU82058.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|189369451, gi... - gi\|189369451\|gb\|EDU87867.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|15833085, gi\|... - gi\|15833085\|ref\|NP_311858.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 str. Sakai], g... gi\|208728162, gi... - gi\|208808361\|ref\|ZP_03250698.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escheric... gi\|209760010, gi... - pir\|\|G91107 probable oxidase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952),... gi\|195937093 - gi\|195937093\|ref\|ZP_03082475.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 str. EC4024... gi\|168797530, gi... - gi\|189379632\|gb\|EDU98048.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|168785813, gi... - gi\|189374207\|gb\|EDU92623.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escherichia ... gi\|217327366, gi... - gi\|217327366\|ref\|ZP_03443449.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escheric... gi\|209398861, gi... - gi\|209398861\|ref\|YP_002272435.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escheri... gi\|15833085, gi\|... - gi\|15833085\|ref\|NP_311858.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7], gi\|13363303\|... gi\|208740151, gi... - gi\|208820028\|ref\|ZP_03260348.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escheric... gi\|208735709, gi... - gi\|208814432\|ref\|ZP_03255761.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escheric...	356.0	[0..1]	[378..1]
gi\|91073911, gi\|... - gi\|91212337\|ref\|YP_542323.1\| coproporphyrinogen III oxidase [Escherichia coli UTI89], gi\|91073911\|gb... gi\|226899432, gi... - gi\|237706392\|ref\|ZP_04536873.1\| coproporphyrinogen III oxidase [Escherichia sp. 3_2_53FAA], gi\|22689... gi\|218366715, gi... - gi\|218559946\|ref\|YP_002392859.1\| coproporphyrinogen III oxidase [Escherichia coli S88], gi\|218366715... gi\|117625182, gi... - gi\|117625182\|ref\|YP_854170.1\| coproporphyrinogen III oxidase [Escherichia coli APEC O1], gi\|11551430...	355.0	[0..1]	[378..1]
gi\|83587647, gi\|... - gi\|83587647\|ref\|ZP_00926274.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta...	354.0	[0..1]	[378..1]
gi\|187733274, gi... - gi\|75178855\|ref\|ZP_00698891.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|190902042, gi... - gi\|75228911\|ref\|ZP_00715508.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta... gi\|81246833, gi\|... - gi\|82545422\|ref\|YP_409369.1\| coproporphyrinogen III oxidase [Shigella boydii Sb227], gi\|81246833\|gb\|...	354.0	[0..1]	[378..1]
gi\|12517501, gi\|... - gi\|15803494\|ref\|NP_289527.1\| coproporphyrinogen III oxidase [Escherichia coli O157:H7 EDL933], gi\|12... gi\|25284557 - pir\|\|B85953 probable oxidase yggW [imported] - Escherichia coli (strain O157:H7, substrain EDL933)	353.0	[0..1]	[378..1]
gi\|226839629, gi... - gi\|254038005\|ref\|ZP_04872063.1\| oxygen-independent coproporphyrinogen III oxidase [Escherichia sp. 1... gi\|124502249, gi... - gi\|124526145\|ref\|ZP_01698150.1\| putative oxygen-independent coproporphyrinogen III oxidase [Escheric... gi\|170018804, gi... - gi\|170018804\|ref\|YP_001723758.1\| coproporphyrinogen III oxidase [Escherichia coli ATCC 8739], gi\|169... gi\|157162416, gi... - gi\|75196904\|ref\|ZP_00706974.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta...	352.0	[0..1]	[378..1]
gi\|26249376, gi\|... - gi\|26249376\|ref\|NP_755416.1\| coproporphyrinogen III oxidase [Escherichia coli CFT073], gi\|26109784\|g...	352.0	[0..1]	[378..1]
gi\|125621178, gi... - gi\|75819189\|ref\|ZP_00749282.1\| COG0635: Coproporphyrinogen III oxidase and related Fe-S oxidoreducta...	351.0	[0..1]	[378..1]

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Predicted Domain #1

Region A:
Residues: [1-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKLPPLSLY IHIPWCVQKC PYCDFNSHAL KGEVPHDDYV QHLLNDLDND VAYAQGREVK  60
   61 TIFIGGGTPS LLSGPAMQTL LDGVRARLPL AADAEITMEA NPGTVEADRF VDYQRAGVNR 120
  121 ISIGVQSFSE EKLKRLGRIH GPQEAKRAAK LASGLGLRSF NLDLMHGLPD QSLEEALGDL 180
  181 RQAIELNPPH LSWYQLTIEP NTLFGSRPPV LPDDDALWDI FEQGHQLLTA AGYQQYETSA 240
  241 YAKPGYQCQH NLNYWRFGDY IGIGCGAHGK VTFPDGRILR TTKTRHPRGF MQGRYLESQR 300
  301 DVEATDKPFE FFMNRFRLLE AAPRVEFIAY TGLCEDVIRP QLDEAIAQGY LTECADYWQI 360
  361 TEHGKLFLNS LLELFLAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.154902
Match:	1oltA
Description:	Coproporphyrinogen III oxidase (HemN) from Escherichia coli is a Radical SAM enzyme.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
coproporphyrinogen oxidase activity	2.41520078366277	bayes_pls_golite062009
biotin synthase activity	2.08611410724267	bayes_pls_golite062009
radical SAM enzyme activity	1.93582371651697	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1.85924424492023	bayes_pls_golite062009
catalytic activity	1.48331922124015	bayes_pls_golite062009
sulfurtransferase activity	0.947420499060224	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	0.107588242235537	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: