YRC Public Data Repository - Protein Structure Prediction

Protein:	YCGE_ECOLI
Organism:	Escherichia coli
Length:	243 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YCGE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|253324881, gi... - gi\|254288054\|ref\|YP_003053802.1\| predicted DNA-binding transcriptional regulator [Escherichia coli B... gi\|194437058, gi... - gi\|83587309\|ref\|ZP_00925937.1\| COG0789: Predicted transcriptional regulators [Escherichia coli 101-1... gi\|251784668, gi... - gi\|251784668\|ref\|YP_002998972.1\| hypothetical protein B21_01145 [Escherichia coli BL21], gi\|24237694... gi\|253973147, gi... - gi\|254161246\|ref\|YP_003044354.1\| predicted DNA-binding transcriptional regulator [Escherichia coli B...	195.0	[0..1]	[243..1]
gi\|85376563 - gi\|85376563\|gb\|ABC70490.1\| putative transcriptional regulator [Escherichia coli] gi\|117623379, gi... - gi\|117623379\|ref\|YP_852292.1\| putative transcriptional regulator [Escherichia coli APEC O1], gi\|1155... gi\|237705110, gi... - gi\|237705110\|ref\|ZP_04535591.1\| transcriptional regulator YcgE [Escherichia sp. 3_2_53FAA], gi\|22689... gi\|218426670, gi... - gi\|218689106\|ref\|YP_002397318.1\| putative DNA-binding transcriptional regulator [Escherichia coli ED... gi\|218364855, gi... - gi\|218558086\|ref\|YP_002390999.1\| putative DNA-binding transcriptional regulator [Escherichia coli S8... gi\|91210371, gi\|... - gi\|91210371\|ref\|YP_540357.1\| transcriptional regulator YcgE [Escherichia coli UTI89], gi\|91071945\|gb...	195.0	[0..1]	[243..1]
gi\|209918396, gi... - gi\|209918396\|ref\|YP_002292480.1\| putative transcriptional regulator [Escherichia coli SE11], gi\|2099... gi\|157080691, gi... - gi\|75190223\|ref\|ZP_00703490.1\| COG0789: Predicted transcriptional regulators [Escherichia coli E2437...	195.0	[0..1]	[243..1]
gi\|188487610, gi... - gi\|75511654\|ref\|ZP_00734301.1\| COG0789: Predicted transcriptional regulators [Escherichia coli 53638...	195.0	[0..1]	[243..1]
gi\|75209217, gi\|... - gi\|75209217\|ref\|ZP_00709464.1\| COG0789: Predicted transcriptional regulators [Escherichia coli B171]...	195.0	[0..1]	[243..1]
gi\|74311698, gi\|... - gi\|74311698\|ref\|YP_310117.1\| putative transcriptional regulator [Shigella sonnei Ss046], gi\|73855175...	194.0	[0..1]	[243..1]
gi\|110342973, gi... - gi\|110641381\|ref\|YP_669111.1\| transcriptional regulator YcgE [Escherichia coli 536], gi\|110342973\|gb... gi\|75241970, gi\|... - gi\|75241970\|ref\|ZP_00725764.1\| COG0789: Predicted transcriptional regulators [Escherichia coli F11],... gi\|26247472, gi\|... - gi\|26247472\|ref\|NP_753512.1\| putative transcriptional regulator YcgE [Escherichia coli CFT073], gi\|2... gi\|227836636, gi... - gi\|227886432\|ref\|ZP_04004237.1\| transcriptional regulator YcgE [Escherichia coli 83972], gi\|22783663...	193.0	[0..1]	[243..1]
EG12008 - transcriptional activator of csgD and csgBA / Transcriptional regulator of csgD gi\|15146422\|gb\|A... - MerR-like regulator A [Escherichia coli] EG12008 - transcriptional activator of csgD and csgBA / Transcriptional regulator of csgD gi\|124526704, gi... - gi\|124526704\|ref\|ZP_01698613.1\| transcriptional regulator, MerR family [Escherichia coli B], gi\|1245... gi\|218554691, gi... - gi\|218554691\|ref\|YP_002387604.1\| DNA-binding transcriptional regulator [Escherichia coli IAI1], gi\|2... gi\|218695738, gi... - gi\|218695738\|ref\|YP_002403405.1\| DNA-binding transcriptional regulator [Escherichia coli 55989], gi\|... gi\|157080228, gi... - gi\|75186917\|ref\|ZP_00700184.1\| COG0789: Predicted transcriptional regulators [Escherichia coli E2437... gi\|226237481 - gi\|226237481\|dbj\|BAH47003.1\| DNA-binding transcriptional regulator [Escherichia coli O55:H7] gi\|238901310, gi... - gi\|238901310\|ref\|YP_002927106.1\| DNA-binding transcriptional regulator [Escherichia coli BW2952], gi... gi\|89108943, gi\|... - gi\|89108943\|ref\|AP_002723.1\| DNA-binding transcriptional regulator [Escherichia coli str. K-12 subst... gi\|75231533, gi\|... - gi\|75231533\|ref\|ZP_00717902.1\| COG0789: Predicted transcriptional regulators [Escherichia coli B7A],... gi\|169754483, gi... - gi\|170019555\|ref\|YP_001724509.1\| MerR family transcriptional regulator [Escherichia coli ATCC 8739],... gi\|170081749, gi... - gi\|170081749\|ref\|YP_001731069.1\| DNA-binding transcriptional regulator [Escherichia coli str. K-12 s... MLRA_ECOLI - HTH-type transcriptional regulator mlrA (MerR-like regulator A) - Escherichia coli gi\|209912845, gi... - gi\|209919586\|ref\|YP_002293670.1\| putative transcriptional regulator [Escherichia coli SE11], gi\|2099...	190.0	[0..1]	[239..1]
gi\|190909645, gi... - gi\|75242944\|ref\|ZP_00726650.1\| COG0789: Predicted transcriptional regulators [Escherichia coli F11],... gi\|110343927, gi... - gi\|110642335\|ref\|YP_670065.1\| MerR-like regulator A [Escherichia coli 536], gi\|110343927\|gb\|ABG70164...	189.0	[0..1]	[239..1]

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Predicted Domain #1

Region A:
Residues: [1-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYYSIGDVA ERCGINPVTL RAWQRRYGLL KPQRSEGGHR LFDEEDIQRI EEIKRWISNG  60
   61 VPVGKVKALL ETTSQDTEDD WSRLQEEMMS ILRMANPAKL RARIISLGRE YPVDQLINHV 120
  121 YLPVRQRLVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.154902
Match:	1q05A
Description:	Crystal structure of the Cu(I) form of E. coli CueR, a copper efflux regulator
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [131-243]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHNTSRIMSS MFDGALIEYA ATSLFEMRRK PGKEAILMAW NVEERARLWL EAWRLSLSGW  60
   61 HISVLADPIE SPRPELFPTQ TLIVWTGMAP TRRQNELLQH WGEQGYKVIF HAP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.897	0.546	regulation of transcription, DNA-dependent	c.23.1	CheY-like
View	Download	0.979	0.104	nucleotide binding	c.30.1	PreATP-grasp domain
View	Download	0.955	0.000	transcription factor activity	c.23.6	Cobalamin (vitamin B12)-binding domain
View	Download	0.900	N/A	N/A	c.23.6	Cobalamin (vitamin B12)-binding domain
View	Download	0.875	N/A	N/A	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits