YRC Public Data Repository - Protein Structure Prediction

Protein:	YBDH_ECOLI
Organism:	Escherichia coli
Length:	362 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YBDH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|89210581, gi\|... - gi\|89210581\|ref\|ZP_01188969.1\| Iron-containing alcohol dehydrogenase:Aldehyde dehydrogenase [Halothe...	307.0	[0..1]	[362..465]
gi\|114845300, gi... - gi\|167039286\|ref\|YP_001662271.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Thermoanaeroba...	307.0	[0..5]	[358..466]
gi\|241903602, gi... - gi\|241903602\|ref\|ZP_04788323.1\| iron-containing alcohol dehydrogenase [Thermoanaerobacter brockii su... gi\|76588428, gi\|... - gi\|76796158\|ref\|ZP_00778525.1\| Iron-containing alcohol dehydrogenase [Thermoanaerobacter ethanolicus...	306.0	[0..5]	[358..466]
gi\|77995475, gi\|... - gi\|78043360\|ref\|YP_359772.1\| putative lactaldehyde reductase [Carboxydothermus hydrogenoformans Z-29...	305.0	[0..9]	[358..6]
gi\|111143367 - gi\|111143367\|gb\|ABH06551.1\| alcohol/aldehyde dehydrogenase [Thermoanaerobacter ethanolicus]	304.0	[0..5]	[358..466]
gi\|98660195 - gi\|98660195\|dbj\|GAA02506.1\| unnamed protein product [Pelotomaculum thermopropionicum SI]	303.0	[0..9]	[358..50]
gi\|52307909, gi\|... - gi\|52425857\|ref\|YP_088994.1\| EutG protein [Mannheimia succiniciproducens MBEL55E], gi\|52307909\|gb\|AA...	292.0	[0..9]	[360..10]
gi\|56178914, gi\|... - gi\|56459904\|ref\|YP_155185.1\| alcohol dehydrogenase [Idiomarina loihiensis L2TR], gi\|56178914\|gb\|AAV8...	292.0	[0..7]	[358..3]
gi\|28211045, gi\|... - gi\|28211045\|ref\|NP_781989.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Clostridium tetani...	291.0	[0..5]	[359..448]

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Predicted Domain #1

Region A:
Residues: [1-362]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPHNPIRVVV GPANYFSHPG SFNHLHDFFT DEQLSRAVWI YGKRAIAAAQ TKLPPAFGLP  60
   61 GAKHILFRGH CSESDVQQLA AESGDDRSVV IGVGGGALLD TAKALARRLG LPFVAVPTIA 120
  121 ATCAAWTPLS VWYNDAGQAL HYEIFDDANF MVLVEPEIIL NAPQQYLLAG IGDTLAKWYE 180
  181 AVVLAPQPET LPLTVRLGIN NAQAIRDVLL NSSEQALSDQ QNQQLTQSFC DVVDAIIAGG 240
  241 GMVGGLGDRF TRVAAAHAVH NGLTVLPQTE KFLHGTKVAY GILVQSALLG QDDVLAQLTG 300
  301 AYQRFHLPTT LAELEVDINN QAEIDKVIAH TLRPVESIHY LPVTLTPDTL RAAFKKVESF 360
  361 KA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.0
Match:	1kq3A
Description:	Glycerol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.37357608468991	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.22441244261645	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	1.71338912033383	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.56034560750419	bayes_pls_golite062009
oxidoreductase activity	0.858931502957991	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: