YRC Public Data Repository - Protein Structure Prediction

Protein:	UXAC_ECOLI
Organism:	Escherichia coli
Length:	470 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UXAC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|254038262, gi... - gi\|254038262\|ref\|ZP_04872320.1\| uronate isomerase [Escherichia sp. 1_1_43], gi\|226839886\|gb\|EEH71907... gi\|26110109, gi\|... - gi\|26249681\|ref\|NP_755721.1\| uronate isomerase [Escherichia coli CFT073], gi\|26110109\|gb\|AAN82295.1\|... gi\|91074095, gi\|... - gi\|91212521\|ref\|YP_542507.1\| glucuronate isomerase [Escherichia coli UTI89], gi\|91074095\|gb\|ABE08976... gi\|24053557, gi\|... - ref\|NP_708897.1\| uronate isomerase [Shigella flexneri 2a str. 301], gb\|AAN44604.1\| uronate isomeras... gi\|237706147, gi... - gi\|237706147\|ref\|ZP_04536628.1\| uronate isomerase [Escherichia sp. 3_2_53FAA], gi\|226899187\|gb\|EEH85...	788.0	[0..1]	[470..22]
gi\|193061974, gi... - gi\|75260023\|ref\|ZP_00731301.1\| COG1904: Glucuronate isomerase [Escherichia coli E22], gi\|193061974\|r... gi\|192959465, gi... - gi\|75239339\|ref\|ZP_00723310.1\| COG1904: Glucuronate isomerase [Escherichia coli E110019], gi\|1930675... UXAC_ECO8A - Uronate isomerase OS=Escherichia coli O8 (strain IAI1) GN=uxaC PE=3 SV=1 UXAC_ECO55 - Uronate isomerase OS=Escherichia coli (strain 55989 / EAEC) GN=uxaC PE=3 SV=1 UXAC_ECOSE - Uronate isomerase OS=Escherichia coli (strain SE11) GN=uxaC PE=3 SV=1	786.0	[0..1]	[470..1]
gi\|75229992, gi\|... - gi\|75229992\|ref\|ZP_00716505.1\| COG1904: Glucuronate isomerase [Escherichia coli B7A], gi\|191166880\|r...	785.0	[0..1]	[470..1]
gi\|195938313 - gi\|195938313\|ref\|ZP_03083695.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4024] gi\|189379652, gi... - gi\|189379652\|gb\|EDU98068.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC508], gi\|16879768... gi\|189374162, gi... - gi\|189374162\|gb\|EDU92578.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC869], gi\|16878597... gi\|189001074, gi... - gi\|189001074\|gb\|EDU70060.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4076], gi\|1687812... UXAC_ECO5E - Uronate isomerase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=uxaC PE=3 SV=1 gi\|208740541, gi... - gi\|208820418\|ref\|ZP_03260738.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4042], gi\|208... gi\|208812615, gi... - gi\|208812615\|ref\|ZP_03253944.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4045], gi\|208... gi\|208808902, gi... - gi\|208808902\|ref\|ZP_03251239.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|254795043, gi... - gi\|254795043\|ref\|YP_003079880.1\| uronate isomerase [Escherichia coli O157:H7 str. TW14359], gi\|25459... gi\|25351854, gi\|... - pir\|\|F91125 uronate isomerase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952)... gi\|168749315, gi... - gi\|188016382\|gb\|EDU54504.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4113], gi\|1687493... UXAC_ECO57 - Uronate isomerase OS=Escherichia coli O157:H7 GN=uxaC PE=3 SV=1 gi\|168773246, gi... - gi\|187770754\|gb\|EDU34598.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4196], gi\|1687732... gi\|168769505, gi... - gi\|189361439\|gb\|EDU79858.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4486], gi\|1687695... gi\|189367608, gi... - gi\|189367608\|gb\|EDU86024.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4501], gi\|1687620... gi\|189358495, gi... - gi\|189358495\|gb\|EDU76914.1\| glucuronate isomerase [Escherichia coli O157:H7 str. EC4401], gi\|1687540... gi\|13363447, gi\|... - gi\|15833228\|ref\|NP_312001.1\| glucuronate isomerase [Escherichia coli O157:H7 str. Sakai], gi\|1336344... gi\|217326789, gi... - gi\|217326789\|ref\|ZP_03442872.1\| glucuronate isomerase [Escherichia coli O157:H7 str. TW14588], gi\|21...	784.0	[0..1]	[470..1]
gi\|194427756, gi... - gi\|75211044\|ref\|ZP_00711157.1\| COG1904: Glucuronate isomerase [Escherichia coli B171], gi\|194427756\|...	784.0	[0..1]	[470..1]
UXAC_SHIB3 - Uronate isomerase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=uxaC PE=3 SV=1	783.0	[0..1]	[470..1]
gi\|15803633, gi\|... - gi\|15803633\|ref\|NP_289666.1\| glucuronate isomerase [Escherichia coli O157:H7 EDL933], gi\|12517682\|gb... gi\|25351859 - gi\|25351859\|pir\|\|E85970 uronate isomerase [imported] - Escherichia coli (strain O157:H7, substrain E...	779.0	[0..1]	[470..1]
gi\|77963583, gi\|... - gi\|77963583\|ref\|ZP_00827392.1\| COG1904: Glucuronate isomerase [Yersinia mollaretii ATCC 43969], gi\|2...	775.0	[0..1]	[469..1]
gi\|238785421, gi... - gi\|77957176\|ref\|ZP_00821239.1\| COG1904: Glucuronate isomerase [Yersinia bercovieri ATCC 43970], gi\|2...	772.0	[0..1]	[469..1]
gi\|77976512 - gi\|77976512\|ref\|ZP_00831997.1\| COG1904: Glucuronate isomerase [Yersinia intermedia ATCC 29909]	771.0	[0..1]	[469..9]

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Predicted Domain #1

Region A:
Residues: [1-470]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPFMTEDFL LDTEFARRLY HDYAKDQPIF DYHCHLPPQQ IAEDYRFKNL YDIWLKGDHY  60
   61 KWRAMRTNGV AERLCTGDAS DREKFDAWAA TVPHTIGNPL YHWTHLELRR PFGITGKLLS 120
  121 PSTADEIWNE CNELLAQDNF SARGIMQQMN VKMVGTTDDP IDSLEHHAEI AKDGSFTIKV 180
  181 LPSWRPDKAF NIEQATFNDY MAKLGEVSDT DIRRFADLQT ALTKRLDHFA AHGCKVSDHA 240
  241 LDVVMFAEAN EAELDSILAR RLAGETLSEH EVAQFKTAVL VFLGAEYARR GWVQQYHIGA 300
  301 LRNNNLRQFK LLGPDVGFDS INDRPMAEEL SKLLSKQNEE NLLPKTILYC LNPRDNEVLG 360
  361 TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM ERQMTQLAQL GLLSRFVGML TDSRSFLSYT 420
  421 RHEYFRRILC QMIGRWVEAG EAPADINLLG EMVKNICFNN ARDYFAIELN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	147.0
Match:	1j5sA
Description:	Uronate isomerase TM0064
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.072432847481	bayes_pls_golite062009
hydrolase activity	2.06578679075873	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.481958484200481	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.34437054835538	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: