YRC Public Data Repository - Protein Structure Prediction

Protein:	TYRA_ECOLI
Organism:	Escherichia coli
Length:	373 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYRA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|188495016, gi... - gi\|75513206\|ref\|ZP_00735648.1\| COG0287: Prephenate dehydrogenase [Escherichia coli 53638], gi\|188495...	316.0	[0..1]	[373..1]
gi\|226899852, gi... - gi\|237706812\|ref\|ZP_04537293.1\| fused chorismate mutase P/prephenate dehydratase [Escherichia sp. 3_... gi\|115513945, gi... - gi\|117624821\|ref\|YP_853734.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichia c... gi\|218366289, gi... - gi\|218559520\|ref\|YP_002392433.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichi... gi\|227888166, gi... - gi\|227888166\|ref\|ZP_04005971.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichia... gi\|26248963, gi\|... - gi\|26248963\|ref\|NP_755003.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichia co... gi\|91211934, gi\|... - gi\|91211934\|ref\|YP_541920.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichia co...	315.0	[0..1]	[373..1]
gi\|190905147, gi... - gi\|75236022\|ref\|ZP_00720156.1\| COG0287: Prephenate dehydrogenase [Escherichia coli F11], gi\|19117457... gi\|110642761, gi... - gi\|110642761\|ref\|YP_670491.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichia c...	315.0	[0..1]	[373..1]
gi\|24113939, gi\|... - gi\|24113939\|ref\|NP_708449.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Shigella flexn... gi\|30042256, gi\|... - gi\|30064000\|ref\|NP_838171.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Shigella flexn...	315.0	[0..1]	[373..1]
gi\|81246467, gi\|... - gi\|82545056\|ref\|YP_409003.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Shigella boydi...	314.0	[0..1]	[373..1]
gi\|194439357, gi... - gi\|83585232\|ref\|ZP_00923881.1\| COG0287: Prephenate dehydrogenase [Escherichia coli 101-1], gi\|194439... gi\|218428282, gi... - gi\|218690718\|ref\|YP_002398930.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichi... gi\|193071697, gi... - gi\|75214710\|ref\|ZP_00713218.1\| COG0287: Prephenate dehydrogenase [Escherichia coli E110019], gi\|1930... gi\|194430172, gi... - gi\|75208566\|ref\|ZP_00708879.1\| COG0287: Prephenate dehydrogenase [Escherichia coli B171], gi\|1944301... gi\|75196613, gi\|... - gi\|75196613\|ref\|ZP_00706683.1\| COG0287: Prephenate dehydrogenase [Escherichia coli HS], gi\|157162074... gi\|75178211, gi\|... - gi\|75178211\|ref\|ZP_00698270.1\| COG0287: Prephenate dehydrogenase [Shigella boydii BS512], gi\|1877310... gi\|124527999, gi... - gi\|124527999\|ref\|ZP_01699352.1\| chorismate mutase [Escherichia coli B], gi\|124500891\|gb\|EAY48359.1\| ... gi\|74313184, gi\|... - gi\|74313184\|ref\|YP_311603.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Shigella sonne... gi\|169754051, gi... - gi\|170019123\|ref\|YP_001724077.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichi... gi\|75258019, gi\|... - gi\|75258019\|ref\|ZP_00729493.1\| COG0287: Prephenate dehydrogenase [Escherichia coli E22], gi\|19306402... gi\|191169067, gi... - gi\|75227669\|ref\|ZP_00714410.1\| COG0287: Prephenate dehydrogenase [Escherichia coli B7A], gi\|19116906... gi\|209920075, gi... - gi\|209920075\|ref\|YP_002294159.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichi... gi\|215487938, gi... - gi\|215487938\|ref\|YP_002330369.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Escherichi... gi\|170517542, gi... - gi\|170679824\|ref\|YP_001744783.1\| chorismate mutase/prephenate dehydrogenase [Escherichia coli SMS-3-... gi\|253323550, gi... - gi\|254289331\|ref\|YP_003055079.1\| fused chorismate mutase T/prephenate dehydrogenase [Escherichia col... gi\|194416640, gi... - gi\|194435109\|ref\|ZP_03067345.1\| chorismate mutase/prephenate dehydrogenase [Shigella dysenteriae 101... gi\|251785922, gi... - gi\|251785922\|ref\|YP_003000226.1\| hypothetical protein B21_02453 [Escherichia coli BL21], gi\|24237819... gi\|253974471, gi... - gi\|254162570\|ref\|YP_003045678.1\| fused chorismate mutase T/prephenate dehydrogenase [Escherichia col... gi\|254037676, gi... - gi\|254037676\|ref\|ZP_04871734.1\| chorismate mutase/prephenate dehydrogenase [Escherichia sp. 1_1_43],... gi\|110806733, gi... - gi\|110806733\|ref\|YP_690253.1\| bifunctional chorismate mutase/prephenate dehydrogenase [Shigella flex...	314.0	[0..1]	[373..1]
gi\|238729524, gi... - gi\|77976462\|ref\|ZP_00831950.1\| COG0287: Prephenate dehydrogenase [Yersinia intermedia ATCC 29909], g...	314.0	[0..1]	[372..1]
gi\|157080635, gi... - gi\|75187347\|ref\|ZP_00700614.1\| COG0287: Prephenate dehydrogenase [Escherichia coli E24377A], gi\|1571...	314.0	[0..1]	[373..1]
gi\|121728798, gi... - gi\|75815401\|ref\|ZP_00745912.1\| COG0287: Prephenate dehydrogenase [Vibrio cholerae V52], gi\|121728798... gi\|75826055, gi\|... - gi\|75826055\|ref\|ZP_00755490.1\| COG0287: Prephenate dehydrogenase [Vibrio cholerae O395], gi\|22711707...	314.0	[0..1]	[373..1]
tr\|D7HD77\|D7HD77... - T-protein OS=Vibrio cholerae RC385 GN=VCRC385_00457 PE=4 SV=1 gi\|75824086, gi\|... - gi\|75824086\|ref\|ZP_00753553.1\| COG0287: Prephenate dehydrogenase [Vibrio cholerae RC385], gi\|2542237...	314.0	[0..1]	[373..1]

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Predicted Domain #1

Region A:
Residues: [1-97]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE  60
   61 AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.0
Match:	2d8dA
Description:	No description for 2d8dA was found.

Predicted functions:

Term	Confidence	Notes
chorismate mutase activity	3.92706714868161	bayes_pls_golite062009
prephenate dehydratase activity	2.47223657985094	bayes_pls_golite062009
catalytic activity	1.46550169341481	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [98-373]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRPVVIVGGG GQMGRLFEKM LTLSGYQVRI LEQHDWDRAA DIVADAGMVI VSVPIHVTEQ  60
   61 VIGKLPPLPK DCILVDLASV KNGPLQAMLV AHDGPVLGLH PMFGPDSGSL AKQVVVWCDG 120
  121 RKPEAYQWFL EQIQVWGARL HRISAVEHDQ NMAFIQALRH FATFAYGLHL AEENVQLEQL 180
  181 LALSSPIYRL ELAMVGRLFA QDPQLYADII MSSERNLALI KRYYKRFGEA IELLEQGDKQ 240
  241 AFIDSFRKVE HWFGDYAQRF QSESRVLLRQ ANDNRQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.045757
Match:	2pv7A
Description:	No description for 2pv7A was found.

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.16785883389468	bayes_pls_golite062009
oxidoreductase activity	1.95477050413	bayes_pls_golite062009
prephenate dehydrogenase activity	1.03016160419952	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.771153340292	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.66554302844944	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: