YRC Public Data Repository - Protein Structure Prediction

Protein:	TSX_ECOLI
Organism:	Escherichia coli
Length:	294 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TSX_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|152968936, gi... - gi\|152968936\|ref\|YP_001334045.1\| nucleoside channel; receptor of phage T6 and colicin K [Klebsiella ... TSX_KLEPN - Nucleoside-specific channel-forming protein tsx OS=Klebsiella pneumoniae GN=tsx PE=3 SV=1	290.0	[0..1]	[294..1]
gi\|90328126, gi\|... - gi\|90410913\|ref\|ZP_01218927.1\| Outer membrane protein OmpK [Photobacterium profundum 3TCK], gi\|90328...	281.0	[0..1]	[294..1]
gi\|15800140, gi\|... - gi\|15800140\|ref\|NP_286152.1\| nucleoside channel; receptor of phage T6 and colicin K [Escherichia col... gi\|25348404 - gi\|25348404\|pir\|\|D85537 hypothetical protein tsx [imported] - Escherichia coli (strain O157:H7, sub...	281.0	[0..1]	[294..1]
gi\|194419115, gi... - gi\|83570321\|ref\|ZP_00921766.1\| COG3248: Nucleoside-binding outer membrane protein [Shigella dysenter...	280.0	[0..1]	[294..1]
gi\|237707595, gi... - gi\|237707595\|ref\|ZP_04538076.1\| nucleoside-specific channel-forming protein tsx [Escherichia sp. 3_2... gi\|91071053, gi\|... - gi\|91209479\|ref\|YP_539465.1\| nucleoside channel; receptor of phage T6 and colicin K [Escherichia col... gi\|26106814, gi\|... - gi\|26246416\|ref\|NP_752455.1\| nucleoside-specific channel-forming protein tsx precursor [Escherichia ...	280.0	[0..1]	[294..17]
gi\|74310980, gi\|... - gi\|74310980\|ref\|YP_309399.1\| nucleoside channel [Shigella sonnei Ss046], gi\|73854457\|gb\|AAZ87164.1\| ...	279.0	[0..1]	[294..1]
gi\|187733170, gi... - gi\|75176885\|ref\|ZP_00697001.1\| COG3248: Nucleoside-binding outer membrane protein [Shigella boydii B... gi\|81244310, gi\|... - gi\|82542899\|ref\|YP_406846.1\| Tsx [Shigella boydii Sb227], gi\|81244310\|gb\|ABB65018.1\| Tsx [Shigella b...	279.0	[0..1]	[294..1]
gi\|191173474, gi... - gi\|75238738\|ref\|ZP_00722726.1\| COG3248: Nucleoside-binding outer membrane protein [Escherichia coli ... gi\|110640672, gi... - gi\|110640672\|ref\|YP_668400.1\| nucleoside-specific channel-forming protein tsx precursor [Escherichia... gi\|227884581, gi... - gi\|227884581\|ref\|ZP_04002386.1\| nucleoside-specific channel-forming protein tsx precursor [Escherich... gi\|117622672, gi... - gi\|117622672\|ref\|YP_851585.1\| nucleoside-specific channel-forming protein Tsx [Escherichia coli APEC... gi\|218364089, gi... - gi\|218557320\|ref\|YP_002390233.1\| nucleoside channel, receptor of phage T6 and colicin K [Escherichia... gi\|218425838, gi... - gi\|218688274\|ref\|YP_002396486.1\| nucleoside channel, receptor of phage T6 and colicin K [Escherichia...	277.0	[0..1]	[294..1]
gi\|84388933, gi\|... - gi\|84388933\|ref\|ZP_00991141.1\| outer membrane protein OmpK precursor [Vibrio splendidus 12B01], gi\|8...	277.0	[0..1]	[294..1]
gi\|49613244, gi\|... - gi\|50122718\|ref\|YP_051885.1\| nucleoside-specific channel-forming protein [Pectobacterium atrosepticu...	273.0	[0..1]	[294..5]

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Predicted Domain #1

Region A:
Residues: [1-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTLLAAGA VLALSSSFTV NAAENDKPQY LSDWWHQSVN VVGSYHTRFG PQIRNDTYLE  60
   61 YEAFAKKDWF DFYGYADAPV FFGGNSDAKG IWNHGSPLFM EIEPRFSIDK LTNTDLSFGP 120
  121 FKEWYFANNY IYDMGRNKDG RQSTWYMGLG TDIDTGLPMS LSMNVYAKYQ WQNYGAANEN 180
  181 EWDGYRFKIK YFVPITDLWG GQLSYIGFTN FDWGSDLGDD SGNAINGIKT RTNNSIASSH 240
  241 ILALNYDHWH YSVVARYWHD GGQWNDDAEL NFGNGNFNVR STGWGGYLVV GYNF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.0
Match:	1tlwA
Description:	Tsx structure complexed with thymidine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleoside transmembrane transporter activity	6.37824101433373	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity	3.19177305556798	bayes_pls_golite062009
transporter activity	1.0103803313803	bayes_pls_golite062009
transmembrane transporter activity	0.86669497658554	bayes_pls_golite062009
substrate-specific transporter activity	0.56992532298404	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.4344928497229	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: