YRC Public Data Repository - Protein Structure Prediction

Protein:	HNRNPA3
Organism:	Homo sapiens
Length:	378 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPA3.

Description	E-value	Query Range	Subject Range
gi\|94371573 - gi\|94371573\|ref\|XP_911625.2\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein A3 isofor...	6.0E-43	[1..224]	[1..224]
gi\|2119040, gi\|3... - gi\|399758\|gb\|AAB27595.1\| FBRNP [Homo sapiens], gi\|2119040\|pir\|\|I52962 FBRNP - human	2.0E-41	[1..224]	[1..224]
IPI01022218, IPI... - Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens GN=HNRNPA1 PE=4 SV=1, IPI:IPI01022218.1\|E... gi\|73996145 - gi\|73996145\|ref\|XP_856107.1\| PREDICTED: similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix... gi\|114695690 - gi\|114695690\|ref\|XP_001137220.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein A1 isoform 4 [Pa...	4.0E-41	[23..327]	[2..304]
ROA1_BOVIN - Heterogeneous nuclear ribonucleoprotein A1 - Bos taurus (Bovine) gi\|39654464 - gi\|39654464\|pdb\|1PGZ\|A Chain A, Crystal Structure Of Up1 Complexed With D(Ttagggttag(6-Mi) G); A Hum...	5.0E-41	[23..217]	[1..195]
ROA1_RAT - Heterogeneous nuclear ribonucleoprotein A1 OS=Rattus norvegicus GN=Hnrnpa1 PE=1 SV=3	9.0E-41	[23..325]	[2..302]
gi\|114628933 - gi\|114628933\|ref\|XP_001146413.1\| PREDICTED: similar to Heterogeneous nuclear ribonucleoprotein A1 (H...	1.0E-40	[23..327]	[2..304]

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Predicted Domain #1

Region A:
Residues: [1-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS LREHFEKWGT  60
   61 LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV DGRVVEPKRA VSREDSVKPG 120
  121 AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG KIETIEVMED RQSGKKRGFA FVTFDDHDTV 180
  181 DKIVVQKYHT INGHNCEVKK ALSKQEMQSA GSQRGRGGG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.522879
Match:	1pgzA
Description:	Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.38904784081546	bayes_pls_golite062009
nucleic acid binding	0.535128751388028	bayes_pls_golite062009
RNA binding	0.423111514770653	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [220-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGNFMGRGGN FGGGGGNFGR GGNFGGRGGY GGGGGGSRGS YGGGDGGYNG FGGDGGNYGG  60
   61 GPGYSSRGGY GGGGPGYGNQ GGGYGGGGGY DGYNEGGNFG GGNYGGGGNY NDFGNYSGQQ 120
  121 QSNYGPMKGG SFGGRSSGSP YGGGYGSGGG SGGYGSRRF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.522879
Match:	1deqA
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: