YRC Public Data Repository - Protein Structure Prediction

Protein:	RNC_STRPN
Organism:	Streptococcus pneumoniae
Length:	232 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNC_STRPN.

Description	E-value	Query Range	Subject Range
RNC_STRTD - Ribonuclease 3 OS=Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) GN=rnc PE=3 SV=1	255.0	[0..1]	[227..1]
gi\|55739198, gi\|... - gb\|AAV62839.1\| ribonuclease III [Streptococcus thermophilus CNRZ1066], gb\|AAV60927.1\| ribonuclease ... RNC_STRT1 - Ribonuclease 3 OS=Streptococcus thermophilus (strain CNRZ 1066) GN=rnc PE=3 SV=1 RNC_STRT2 - Ribonuclease 3 OS=Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) GN=rnc PE=3 SV=1	253.0	[0..1]	[227..9]
RNC_STRP2 - Ribonuclease 3 OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) GN=rnc PE=3 SV=1 gi\|25289225 - pir\|\|F98012 ribonuclease III (EC 3.1.26.3) [imported] - Streptococcus pneumoniae (strain R6) RNC_STRR6 - Ribonuclease 3 OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=rnc PE=3 SV=1 gi\|147755517, gi... - gi\|148998680\|ref\|ZP_01826119.1\| ribonuclease III [Streptococcus pneumoniae SP11-BS70], gi\|147755517\|... gi\|147925249, gi... - gi\|148989271\|ref\|ZP_01820651.1\| ribonuclease III [Streptococcus pneumoniae SP6-BS73], gi\|147925249\|g... gi\|168575703, gi... - gi\|183578209\|gb\|EDT98737.1\| ribonuclease III [Streptococcus pneumoniae MLV-016], gi\|168575703\|ref\|ZP... RNC_STRP4 - Ribonuclease 3 OS=Streptococcus pneumoniae serotype 19F (strain G54) GN=rnc PE=3 SV=1	249.0	[0..1]	[232..1]
RNC_LISIN - Ribonuclease 3 OS=Listeria innocua GN=rnc PE=3 SV=1 RNC_LISIN - Ribonuclease 3 OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=rnc PE=3 SV=1	245.0	[0..1]	[227..1]
gi\|153183297, gi... - gi\|254899498\|ref\|ZP_05259422.1\| ribonuclease III [Listeria monocytogenes J0161], gi\|153183297\|ref\|ZP... gi\|127765093, gi... - gi\|254912363\|ref\|ZP_05262375.1\| ribonuclease III [Listeria monocytogenes J2818], gi\|153191314\|ref\|ZP... gi\|153175037, gi... - gi\|254829200\|ref\|ZP_05233887.1\| ribonuclease III [Listeria monocytogenes FSL N3-165], gi\|153175037\|r... gi\|254872588 - gi\|254872588\|ref\|ZP_05245298.1\| ribonuclease III [Listeria monocytogenes FSL N1-017] gi\|47097388, gi\|... - gi\|47097388\|ref\|ZP_00234939.1\| ribonuclease III [Listeria monocytogenes str. 1/2a F6854], gi\|4701423... gi\|153179844, gi... - gi\|254936690\|ref\|ZP_05268387.1\| ribonuclease III [Listeria monocytogenes F6900], gi\|153179844\|ref\|ZP... RNC_LISMH - Ribonuclease 3 OS=Listeria monocytogenes serotype 4a (strain HCC23) GN=rnc PE=3 SV=1	245.0	[0..1]	[227..1]
RNC_LISMO - Ribonuclease 3 OS=Listeria monocytogenes GN=rnc PE=3 SV=1 RNC_LISMO - Ribonuclease 3 OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=rnc PE=3 SV=1 gi\|224501394 - gi\|224501394\|ref\|ZP_03669701.1\| ribonuclease III [Listeria monocytogenes FSL R2-561]	244.0	[0..1]	[228..1]
RNC_STRPM - Ribonuclease 3 OS=Streptococcus pyogenes serotype M28 (strain MGAS6180) GN=rnc PE=3 SV=1 RNC_STRPM - Ribonuclease 3 OS=Streptococcus pyogenes serotype M28 GN=rnc PE=3 SV=1	244.0	[0..1]	[229..1]
RNC_STRPG - Ribonuclease 3 OS=Streptococcus pyogenes serotype M5 (strain Manfredo) GN=rnc PE=3 SV=1 gi\|56808931 - gi\|56808931\|ref\|ZP_00366639.1\| COG0571: dsRNA-specific ribonuclease [Streptococcus pyogenes M49 591] gi\|223523016, gi... - gi\|255591218\|ref\|XP_002535468.1\| ribonuclease III, putative [Ricinus communis], gi\|223523016\|gb\|EEF2... RNC_STRP6 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) GN=rnc PE=3 S... RNC_STRP6 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M6 GN=rnc PE=3 SV=1 RNC_STRPZ - Ribonuclease 3 OS=Streptococcus pyogenes serotype M49 (strain NZ131) GN=rnc PE=3 SV=1	244.0	[0..1]	[229..1]
RNC_STRPD - Ribonuclease 3 OS=Streptococcus pyogenes serotype M2 (strain MGAS10270) GN=rnc PE=3 SV=1	244.0	[0..1]	[229..1]
RNC_STRPQ - Ribonuclease 3 OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN=rnc PE=3 SV=1 gi\|71910251, gi\|... - gi\|71910251\|ref\|YP_281801.1\| ribonuclease III [Streptococcus pyogenes MGAS5005], gi\|71853033\|gb\|AAZ5... RNC_STRP1 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M1 GN=rnc PE=1 SV=1 RNC_STRPY - (P66670) Ribonuclease III (EC 3.1.26.3) (RNase III) RNC_STRP3 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M3 GN=rnc PE=3 SV=1 gi\|13621744, gi\|... - gi\|15674631\|ref\|NP_268805.1\| ribonuclease III [Streptococcus pyogenes M1 GAS], gi\|13621744\|gb\|AAK335... RNC_STRP8 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M18 GN=rnc PE=3 SV=1 RNC_STRPF - Ribonuclease 3 OS=Streptococcus pyogenes serotype M4 (strain MGAS10750) GN=rnc PE=3 SV=1 RNC_STRP3 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) GN=rnc PE=3 SV=... RNC_STRP8 - Ribonuclease 3 OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=rnc PE=3 SV=1 RNC_STRPB - Ribonuclease 3 OS=Streptococcus pyogenes serotype M12 (strain MGAS2096) GN=rnc PE=3 SV=1 RNC_STRPC - Ribonuclease 3 OS=Streptococcus pyogenes serotype M12 (strain MGAS9429) GN=rnc PE=3 SV=1	244.0	[0..1]	[229..1]

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Predicted Domain #1

Region A:
Residues: [1-232]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKELQTVLKN HFAIEFADKK LLETAFTHTS YANEHRLLKI SHNERLEFLG DAVLQLLISE  60
   61 YLYKKYPKKP EGDLSKLRAM IVREESLAGF ARDCQFDQFI KLGKGEEKSG GRNRDTILGD 120
  121 AFEAFLGALL LDKDVAKVKE FIYQVMIPKV EAGEFEMITD YKTHLQELLQ VNGDVAIRYQ 180
  181 VISETGPAHD KVFDVEVLVE GKSIGQGQGR SKKLAEQEAA KNAVEKGLDS CI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.09691
Match:	1o0wA
Description:	RNase III endonuclease catalytic domain; RNase III, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	2.103878681691	bayes_pls_golite062009
endoribonuclease activity	2.02847548000256	bayes_pls_golite062009
endonuclease activity	1.52328576888271	bayes_pls_golite062009
binding	1.36306903445995	bayes_pls_golite062009
nucleic acid binding	1.33734225890407	bayes_pls_golite062009
double-stranded RNA binding	0.80785216315429	bayes_pls_golite062009
catalytic activity	0.328884095744829	bayes_pls_golite062009
protein binding	0.018276859224266	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: