YRC Public Data Repository - Protein Structure Prediction

Protein:	RNC_BORBU
Organism:	Borrelia burgdorferi
Length:	246 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNC_BORBU.

Description	E-value	Query Range	Subject Range
RNC_BORAP - Ribonuclease 3 OS=Borrelia afzelii (strain PKo) GN=rnc PE=3 SV=1	251.0	[0..2]	[246..1]
gi\|219672120, gi... - gi\|219684131\|ref\|ZP_03539075.1\| ribonuclease III [Borrelia garinii PBr], gi\|219672120\|gb\|EED29173.1\|... RNC_BORGA - Ribonuclease 3 OS=Borrelia garinii GN=rnc PE=3 SV=1 RNC_BORBP - Ribonuclease 3 OS=Borreliella bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) GN=rnc PE=3 SV=1	251.0	[0..2]	[246..1]
gi\|62128779, gi\|... - gi\|62181146\|ref\|YP_217563.1\| ribonuclease III [Salmonella enterica subsp. enterica serovar Choleraes...	248.0	[0..19]	[242..25]
RNC_VIBTL - Ribonuclease 3 OS=Vibrio tasmaniensis (strain LGP32) GN=rnc PE=3 SV=1 gi\|84376758, gi\|... - gi\|84390104\|ref\|ZP_00991366.1\| ribonuclease III [Vibrio splendidus 12B01], gi\|84376758\|gb\|EAP93633.1... gi\|86146359, gi\|... - gi\|86146359\|ref\|ZP_01064683.1\| ribonuclease III [Vibrio sp. MED222], gi\|85835838\|gb\|EAQ53972.1\| ribo...	246.0	[0..15]	[243..1]
gi\|194538394, gi... - gi\|75854070\|ref\|ZP_00761790.1\| COG0571: dsRNA-specific ribonuclease [Vibrio sp. Ex25], gi\|254230524\|...	246.0	[0..15]	[241..1]
gi\|91227852, gi\|... - gi\|91227852\|ref\|ZP_01262025.1\| ribonuclease III [Vibrio alginolyticus 12G01], gi\|91188362\|gb\|EAS7465...	245.0	[0..15]	[241..1]
gi\|153839958, gi... - gi\|153839958\|ref\|ZP_01992625.1\| ribonuclease III [Vibrio parahaemolyticus AQ3810], gi\|149746517\|gb\|E... RNC_VIBPA - Ribonuclease 3 OS=Vibrio parahaemolyticus GN=rnc PE=3 SV=1 RNC_VIBPA - Ribonuclease 3 OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=rnc PE=3 SV=1	245.0	[0..15]	[241..1]
gi\|197335272, gi... - gi\|197335272\|ref\|YP_002156886.1\| ribonuclease III [Vibrio fischeri MJ11], gi\|197316762\|gb\|ACH66209.1... RNC_VIBF1 - Ribonuclease 3 OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=rnc PE=3 SV=1	245.0	[0..15]	[241..1]
gi\|126509385, gi... - gi\|153820073\|ref\|ZP_01972740.1\| ribonuclease III [Vibrio cholerae NCTC 8457], gi\|126509385\|gb\|EAZ719... gi\|254845291, gi... - gi\|254849586\|ref\|ZP_05238936.1\| ribonuclease III [Vibrio cholerae MO10], gi\|254845291\|gb\|EET23705.1\|... RNC_VIBCH - Ribonuclease 3 OS=Vibrio cholerae GN=rnc PE=3 SV=1 gi\|229512326, gi... - gi\|229512326\|ref\|ZP_04401805.1\| ribonuclease III [Vibrio cholerae B33], gi\|229352291\|gb\|EEO17232.1\| ... RNC_VIBCM - Ribonuclease 3 OS=Vibrio cholerae serotype O1 (strain M66-2) GN=rnc PE=3 SV=1 gi\|229519462, gi... - gi\|229519462\|ref\|ZP_04408905.1\| ribonuclease III [Vibrio cholerae RC9], gi\|229344151\|gb\|EEO09126.1\| ... gi\|229507479, gi... - gi\|229507479\|ref\|ZP_04396984.1\| ribonuclease III [Vibrio cholerae BX 330286], gi\|229354984\|gb\|EEO199... gi\|229606984, gi... - gi\|229606984\|ref\|YP_002877632.1\| ribonuclease III [Vibrio cholerae MJ-1236], gi\|229369639\|gb\|ACQ6006... RNC_VIBCH - Ribonuclease 3 OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=rnc PE=3 ... gi\|153222435, gi... - gi\|153222435\|ref\|ZP_01953169.1\| ribonuclease III [Vibrio cholerae MAK 757], gi\|124118872\|gb\|EAY37615... gi\|121590982, gi... - gi\|121590982\|ref\|ZP_01678301.1\| ribonuclease III [Vibrio cholerae 2740-80], gi\|121547159\|gb\|EAX57288...	244.0	[0..15]	[241..1]
RNC_SALCH - Ribonuclease 3 OS=Salmonella choleraesuis GN=rnc PE=3 SV=2 RNC_SALCH - Ribonuclease 3 OS=Salmonella choleraesuis (strain SC-B67) GN=rnc PE=3 SV=2 RNC_SALCH - Ribonuclease 3 OS=Salmonella choleraesuis GN=rnc PE=3 SV=2	244.0	[0..19]	[242..6]

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Predicted Domain #1

Region A:
Residues: [1-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKKKSSDFC LCNERKSQLS KFLENLSIDF SNFDLLNTAL CHSSYSNELD QKSSNNERLE  60
   61 FLGDSVLNLI ITDHLYKTYP NKSEGELSKA RSYIVSEDSL SNIAREINLG SYILLGRGEE 120
  121 SNDGRNKKGI LADAIEAFVG AIYLDSGFSR ATEFVVGLFD MYIRLMFNRG DFKDYKSLLQ 180
  181 EYVQKKYKIS PSYKLDKEIG PDHDKVFCVE LYVGENFISN GKGKSKKEAE MRAAEVALKA 240
  241 MENINL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.221849
Match:	1o0wA
Description:	RNase III endonuclease catalytic domain; RNase III, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	2.103878681691	bayes_pls_golite062009
endoribonuclease activity	2.02847548000256	bayes_pls_golite062009
endonuclease activity	1.52328576888271	bayes_pls_golite062009
binding	1.36306903445995	bayes_pls_golite062009
nucleic acid binding	1.33734225890407	bayes_pls_golite062009
double-stranded RNA binding	0.80785216315429	bayes_pls_golite062009
catalytic activity	0.328884095744829	bayes_pls_golite062009
protein binding	0.018276859224266	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: