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View Structure Prediction Details

Protein: PUM1
Organism: Homo sapiens
Length: 1186 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUM1.

Description E-value Query
Range
Subject
Range
gi|73950060 - gi|73950060|ref|XP_865319.1| PREDICTED: similar to pumilio 1 isoform 2 isoform 14 [Canis familiaris]
0.0 [1..1186] [1..1186]
gi|29748037, gi|... - gi|29748037|gb|AAH50747.1| Pum1 protein [Mus musculus], gi|227430382|ref|NP_001153075.1| pumilio 1 i...
0.0 [1..1186] [1..1186]
ENSMMUT000000189... - null, null
gi|66932909 - gi|66932909|ref|NP_001018494.1| pumilio 1 isoform 1 [Homo sapiens]
0.0 [1..1186] [1..1188]
gi|55732279 - gi|55732279|emb|CAH92843.1| hypothetical protein [Pongo abelii]
PUM1_PONAB - Pumilio homolog 1 OS=Pongo abelii GN=PUM1 PE=2 SV=1
0.0 [1..1186] [1..1186]
PUM1_CHICK - Pumilio homolog 1 OS=Gallus gallus GN=PUM1 PE=2 SV=1
0.0 [1..1186] [1..1189]

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Predicted Domain #1
Region A:
Residues: [1-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT  60
   61 HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH 120
  121 QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS 180
  181 DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [232-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSCLRKGGFG PRDADSDEND KGEKKNKGTF DGDKLGDLKE EGDVMDKTNG LPVQNGIDAD  60
   61 VKDFSRTPGN CQNSANEVDL LGPNQNGSEG LAQLT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [327-510]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STNGAKPVED FSNMESQSVP LDPMEHVGME PLQFDYSGTQ VPVDSAAATV GLFDYNSQQQ  60
   61 LFQRPNALAV QQLTAAQQQQ YALAAAHQPH IGLAPAAFVP NPYIISAAPP GTDPYTAGLA 120
  121 AAATLGPAVV PHQYYGVTPW GVYPASLFQQ QAAAAAAATN SANQQTTPQA QQGQQQVLRG 180
  181 GASQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [511-828]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG QGLAAGMPGY PVLAPAAYYD QTGALVVNAG  60
   61 ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA AAASANGAAG GLAGTTNGPF RPLGTQQPQP 120
  121 QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL FSQGSAQPAN TSLGFGSSSS LGATLGSALG 180
  181 GFGTAVANSN TGSGSRRDSL TGSSDLYKRT SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS 240
  241 QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG SGRYISAAPG AEAKYRSASS ASSLFSPSST 300
  301 LFSSSRLRYG MSDVMPSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [829-1186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSRLLEDFRN NRYPNLQLRE IAGHIMEFSQ DQHGSRFIQL KLERATPAER QLVFNEILQA  60
   61 AYQLMVDVFG NYVIQKFFEF GSLEQKLALA ERIRGHVLSL ALQMYGCRVI QKALEFIPSD 120
  121 QQNEMVRELD GHVLKCVKDQ NGNHVVQKCI ECVQPQSLQF IIDAFKGQVF ALSTHPYGCR 180
  181 VIQRILEHCL PDQTLPILEE LHQHTEQLVQ DQYGNYVIQH VLEHGRPEDK SKIVAEIRGN 240
  241 VLVLSQHKFA SNVVEKCVTH ASRTERAVLI DEVCTMNDGP HSALYTMMKD QYANYVVQKM 300
  301 IDVAEPGQRK IVMHKIRPHI ATLRKYTYGK HILAKLEKYY MKNGVDLGPI CGPPNGII

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 158.0
Match: 1ib2A
Description: Pumilio 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.786930091838216 bayes_pls_golite062009
protein binding 0.273418027792729 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle